Article
Gastroenterology & Hepatology
Jayendra Seetharaman, Ujjal Poddar, Surender Kumar Yachha, Anshu Srivastava, Moinak Sen Sarma
Summary: This open-label trial evaluated the efficacy of amitriptyline in pediatric functional abdominal pain disorder (FAPD). The results showed that amitriptyline significantly improved pain and quality of life compared to placebo. Amitriptyline was the only factor predictive of treatment response. This study suggests that more frequent use of amitriptyline in clinical settings is warranted due to its safety and efficacy.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Gastroenterology & Hepatology
Miriam B. Vos, Mark L. Van Natta, Niviann M. Blondet, Srinivasan Dasarathy, Mark Fishbein, Paula Hertel, Ajay K. Jain, Saul J. Karpen, Joel E. Lavine, Saeed Mohammad, Laura A. Miriel, Jean P. Molleston, Marialena Mouzaki, Arun Sanyal, Emily P. Sharkey, Jeffrey B. Schwimmer, James Tonascia, Laura A. Wilson, Stavra A. Xanthakos
Summary: This study aimed to evaluate the effect of losartan on ALT levels in children with NAFLD. The results showed that losartan did not significantly reduce ALT levels, but it did significantly decrease alkaline phosphatase and systolic blood pressure.
Article
Orthopedics
Irem Gul Dogan, Ceren Gursen, Turkan Akbayrak, Yasemin Hatice Balaban, Cavansir Vahabov, Esra Uzelpasaci, Serap Ozgul
Summary: This study investigated the effects of abdominal massage on the severity of constipation, bowel function, and quality of life in patients with functional chronic constipation. The results showed that abdominal massage had a significant impact on improving constipation severity, bowel function, and quality of life. Abdominal massage should be considered as a first-line therapy for functional chronic constipation.
Article
Obstetrics & Gynecology
Pei Shuang Li, Xue Mei Peng, Xiang Xin Niu, Ling Xu, Ernest Hung Yu Ng, Chi Chiu Wang, Jin Fang Dai, Jun Lu, Rui Ning Liang
Summary: This study evaluated the efficacy and safety of acupuncture in the treatment of endometriosis-associated pain. The results showed that acupuncture could relieve pain, shorten pain duration, and improve quality of life in patients. However, the efficacy decreased gradually after discontinuation of treatment.
FERTILITY AND STERILITY
(2023)
Article
Anesthesiology
Kelsey M. Flowers, Megan E. Patton, Valerie J. Hruschak, Kara G. Fields, Emily Schwartz, Jose Zeballos, James D. Kang, Rob R. Edwards, Ted J. Kaptchuk, Kristin L. Schreiber
Summary: Recent evidence suggests that transparently prescribed open-label placebos can induce placebo effects. Combining conditioning with OLP may reduce early postoperative opioid consumption without increasing pain.
Article
Pediatrics
Natoshia R. Cunningham, Anne Kalomiris, James Peugh, Michael Farrell, Scott Pentiuk, Daniel Mallon, Christine Le, Erin Moorman, Lauren Fussner, Richa Aggarwal Dutta, Susmita Kashikar-Zuck
Summary: The study demonstrated that tailoring care based on patient need may optimize the use of limited psychotherapeutic resources while enhancing care. Enhanced usual care was effective for only 8% of youth, with participants receiving ADAPT plus medical treatment showing significantly greater improvements in pain-related disability and anxiety symptoms compared to those receiving only medical treatment. Anxiety levels and ADAPT dose did not moderate the effect of treatment on disability or pain.
JOURNAL OF PEDIATRICS
(2021)
Article
Food Science & Technology
Samuel A. Goldlust, Mojgan Kavoosi, Jennifer Nezzer, Mehran Kavoosi, Walter Korz, Kenneth Deck
Summary: The study found that tetrodotoxin (TTX) may have potential efficacy in treating chemotherapy-induced neuropathic pain (CINP). Although there was no significant difference in average Numeric Pain Rating Scale (NPRS) scores, the 30 μg twice daily TTX cohort showed significant differences from the placebo group in some secondary quality of life (QOL) indicators. Adverse events were mostly mild to moderate, with oral paresthesia and hypoesthesia being the most common.
Article
Pharmacology & Pharmacy
Yue-Li Sun, Min Yao, Yue-Feng Zhu, Meng-Chen Yin, Jin-Tao Liu, Xin Chen, Jin Huang, Yu-Xiang Dai, Wen-Hao Wang, Zeng-Bin Ma, Yong-Jun Wang, Xue-Jun Cui
Summary: The study suggests that patients with shorter disease duration are more likely to overestimate their pain severity in neck pain treatment, due to their limited experience in pain perception, tolerance, and analgesia expectation.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Obstetrics & Gynecology
Emily R. Aldrich, Tiffanie Y. Tam, Leah M. Saylor, Catrina C. Crisp, Jennifer Yeung, Rachel N. Pauls
Summary: This study aimed to evaluate the effect of diazepam rectal suppositories on early postoperative pain after hysterectomy and vaginal reconstruction for pelvic organ prolapse.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2022)
Article
Anesthesiology
Peter E. Amato, John R. Coleman, Tomasz P. Dobrzanski, Donald A. Elmer, Frank W. Gwathmey, April E. Slee, Neil A. Hanson
Summary: This study demonstrates that a preoperative PENG block does not improve analgesia following arthroscopic hip surgery.
REGIONAL ANESTHESIA AND PAIN MEDICINE
(2022)
Article
Obstetrics & Gynecology
Adela G. Cope, Marnie M. Wetzstein, Kristin C. Mara, Shannon K. Laughlin-Tommaso, Nafisseh S. Warner, Tatnai L. Burnett
Summary: This study aimed to assess the impact of abdominal ice packs on opioid use and pain control after laparoscopic hysterectomy. The results showed no significant difference in postoperative opioid use or pain assessment with ice pack use, but most subjects expressed high satisfaction and willingness to recommend ice pack use to others.
JOURNAL OF MINIMALLY INVASIVE GYNECOLOGY
(2021)
Article
Anesthesiology
Jonathan N. Davies, Ben Colagiuri, Louise Sharpe, Melissa A. Day
Summary: This study compared the effects of mindfulness and sham treatments on chronic pain, and found that improvements in pain unpleasantness may be driven by placebo effects rather than mindfulness-specific processes. These findings suggest that further research is needed to understand if mindfulness-specific effects emerge after longer durations of online training.
Article
Gastroenterology & Hepatology
B. D. Wilkie, R. Chandra, J. Chua, D. C. S. Lam, E. D. Paratz, V An, J. O. Keck
Summary: The study found that oral metronidazole did not significantly reduce posthaemorrhoidectomy pain, suggesting it should not be routinely used as an adjunct to analgesia.
COLORECTAL DISEASE
(2021)
Article
Anesthesiology
Ian Gilron, Sylvia Robb, Dongsheng Tu, Ronald Holden, Tanveer Towheed, Dan Ziegler, Louie Wang, Roumen Milev, Christopher Gray
Summary: The study examined the efficacy of alpha-lipoic acid (ALA) as a treatment for fibromyalgia, showing no significant differences in pain intensity compared to placebo. Interestingly, there was a favorable effect of ALA in pain relief for men, but not for women.
Article
Gastroenterology & Hepatology
Jessica Atieh, Daniel Maselli, Margaret Breen-Lyles, Monique Torres, David Katzka, Michael Ryks, Irene Busciglio, Duane Burton, Paula Carlson, W. Scott Harmsen, Michael Camilleri
Summary: This study compared the pharmacodynamics and clinical effects of pharmaceutical-grade CBD and placebo in patients with functional dyspepsia, and found potential interactions between CBD and gene variants.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2022)
Letter
Anesthesiology
Ali Gholamrezaei, Claire E. Ashton-James
Article
Gastroenterology & Hepatology
Ali Gholamrezaei, Ilse Van Diest, Qasim Aziz, Ans Pauwels, Jan Tack, Johan W. S. Vlaeyen, Lukas Van Oudenhove
Summary: The study found that slow, deep breathing can reduce visceral pain intensity, which is not specific to the frequency of slow breathing and is not mediated by autonomic or emotional responses.
NEUROGASTROENTEROLOGY AND MOTILITY
(2022)
Article
Psychology, Biological
Ali Gholamrezaei, Ilse Van Diest, Qasim Aziz, Johan W. S. Vlaeyen, Lukas Van Oudenhove
Summary: The study did not support the hypothesis that adding an inspiratory load to slow, deep breathing enhances its hypoalgesic effects. While pain intensity was slightly lower during SDB with load compared to normal-frequency controlled breathing, the difference was minimal. Heart rate variability was higher during SDB, but emotional responses were less favorable when using load.
Article
Pediatrics
Hamid Bigdelian, Mohsen Sedighi, Mohammad Reza Sabri, Bahar Dehghan, Chehreh Mahdavi, Alireza Ahmadi, Mehdi Ghaderian, Hamid Rahimi, Atefeh Sadeghizadeh, Monirsadat Emadoleslami, Seyed Nasser Mostafavi, Rana Saleh, Niloofar Javadi, Maryam Derakhshan, Zahra Pourmoghaddas, Shima Sarfarazi Moghadam
Summary: This case series describes children with COVID-19 complicated by acute intracardiac thrombosis, confirmed by RT-PCR. Transthoracic echocardiography revealed large intracardiac mobile masses resected successfully via cardiac surgery. The underlying mechanisms of this thrombus may be attributed to the hypercoagulation and inflammatory state induced by SARS-CoV-2 infection.
FRONTIERS IN PEDIATRICS
(2021)
Article
Medicine, General & Internal
Yahya Madihi, Neda Mostofizadeh, Hossein Shamsipour Dehkordi, Maryam Riahinezhad, Silva Hovsepian, Noushin Rostampour, Elham Dehkodi, Mahryar Mehrkash, Tooba Momen, Mahin Hashemipour
Summary: This study aimed to investigate the prevalence of nephrocalcinosis among children with diagnosed congenital adrenal hyperplasia. The results showed a 3.3% prevalence rate of NC, with a higher prevalence in males. Patients with NC had a younger mean age and age of CAH diagnosis, suggesting possible associations with genetic factors.
JOURNAL OF RESEARCH IN MEDICAL SCIENCES
(2022)
Article
Anesthesiology
Abraham B. Beckers, Lukas van Oudenhove, Zsa Zsa R. M. Weerts, Heidi I. L. Jacobs, Nikos Priovoulos, Benedikt A. Poser, Dimo Ivanov, Ali Gholamrezaei, Qasim Aziz, Sigrid Elsenbruch, Ad A. M. Masclee, Daniel Keszthelyi
Summary: The study found that subjects with abdominal pain had more pronounced brain activation during infusion, while activation at the NTS level was independent of subjective pain ratings. These findings contribute to understanding the fundamental mechanism necessary for developing novel therapies aimed at correcting disturbances in visceral afferent pain processing.
Article
Medicine, General & Internal
Shahnaz Armin, Mohammadreza Mirkarimi, Zahra Pourmoghaddas, Marjan Tariverdi, Ahmad Shamsizadeh, Mohsen Alisamir, Maryam Mohammadian, Mohammad Bagher Rahmati, Sedigheh Rafiei Tabatabaei, Roxana Mansour Ghanaiee, Seyed Alireza Fahimzad, Ayeh Yaraghi, Seyedeh Mahsan Hoseini-Alfatemi, Noushin Marhamati, Farzad Esmaeili Tarki, Armin Shirvani, Abdollah Karimi
Summary: This study aimed to predict the severity of COVID-19 in hospitalized children using clinical and paraclinical characteristics. Analyzing variables such as SGOT, CRP, ALC, LDH, WBC, O(2)sat, and ferritin can help in determining the severity of the disease in pediatric patients.
INTERNATIONAL JOURNAL OF CLINICAL PRACTICE
(2022)
Review
Medicine, General & Internal
Nicholas Avery, Amy G. McNeilage, Fiona Stanaway, Claire E. Ashton-James, Fiona M. Blyth, Rebecca Martin, Ali Gholamrezaei, Paul Glare
Summary: This study aimed to review interventions to reduce long term opioid treatment in people with chronic non-cancer pain. Findings suggest that despite limitations, some interventions were shown to help reduce opioid dose and likelihood of discontinuation among patients. However, overall evidence certainty was low.
BMJ-BRITISH MEDICAL JOURNAL
(2022)
Letter
Dermatology
Zahra Pourmoghaddas, Fereshte Rastegarnasab, Ali Mohammad Sabzghabaee, Bahareh Abtahi-Naeini
INTERNATIONAL WOUND JOURNAL
(2023)
Article
Health Care Sciences & Services
Michael R. Magee, Ali Gholamrezaei, Amy G. McNeilage, Alison Sim, Leah Dwyer, Manuela L. Ferreira, Beth D. Darnall, Paul Glare, Claire E. Ashton-James
Summary: Consumers and clinicians generally agreed on the appropriateness and effectiveness of the video script and text content for the mHealth intervention. The majority of draft texts met the acceptability threshold and were included in the pilot intervention, with 56 texts ultimately selected for inclusion.
JMIR FORMATIVE RESEARCH
(2022)
Letter
Dermatology
Bahareh Abtahi-Naeini, Zahra Pourmoghaddas, Fereshte Rastegarnasab, Fateme Ahmadinia
INTERNATIONAL WOUND JOURNAL
(2023)
Article
Medicine, General & Internal
Yahya Madihi, Reza Tavakoli, Maryam Riahinezhad, Neda Mostofizadeh, Mehryar Mehrkash, Noushin Rostampour, Silva Hovsepian
Summary: The study found that 19.4% of the 39 children undergoing dialysis treatment had NAFLD. There were no differences in biochemical and anthropometric characteristics between patients with renal failure with and without NAFLD.
INTERNATIONAL JOURNAL OF PREVENTIVE MEDICINE
(2022)
Article
Pediatrics
Sayed Nassereddin Mostafavi, Atefeh Sadeghizadeh, Sharareh Babaei, Rana Saleh, Amin Dehghan, Saaman Tavakoli, Zahra Pourmoghaddas
Summary: This case report describes an 18-month-old boy with COVID-19-induced sHLH, presenting with high fever, respiratory distress, hepatosplenomegaly, and shock. The patient showed significant improvement after receiving appropriate treatment.
ARCHIVES OF PEDIATRIC INFECTIOUS DISEASES
(2022)
Article
Pediatrics
Sedigheh Rafiei Tabatabaei, Abdollah Karimi, Hamid Rahimi, Shahnaz Armin, Seyed Alireza Fahimzad, Roxana Mansour Ghanaie, Bahar Dehghan, Maryam Kazemiaghdam, Marzieh Alinezhad, Rana Saleh, Shima Saeidi, Narges Sharifi, Davood Ramezani Nezhad, Mina Alibeik, Zahra Pourmoghaddas
Summary: A case report documented the first instance of Kawasaki-like disease in children with COVID-19, followed by a series of three pediatric probable cases exhibiting signs of the syndrome. Three-month follow-up data was also provided.
ARCHIVES OF PEDIATRIC INFECTIOUS DISEASES
(2021)
Article
Pediatrics
Roxana Mansour Ghanaie, Abdollah Karimi, Zahra Pourmoghaddas, Shahnaz Armin, Seyed Alireza Fahimzad, Fatemeh Fallah, Katayoun Tayeri, Mohammad Reza Sabri, Hamid Rahimi, Ali Akbar Zeinaloo, Seyedeh Mahsan Hoseinialfatemi, Vahid Ziaee, Reza Shiari, Bahador Mirrahimi, Ali Saffaei, Sedigheh Rafiei Tabatabaei
ARCHIVES OF PEDIATRIC INFECTIOUS DISEASES
(2021)