Article
Dentistry, Oral Surgery & Medicine
Hiromi Kominato, Kohei Takeda, Koji Mizutani, Risako Mikami, Daisuke Kido, Prima Buranasin, Natsumi Saito, Shu Takemura, Keita Nakagawa, Toshiyuki Nagasawa, Takanori Iwata
Summary: The study found that metformin can improve delayed gingival wound healing in insulin-resistant prediabetes by accelerating the proliferation and migration of human gingival fibroblasts, thereby enhancing the Akt phosphorylation in the insulin signaling pathway.
JOURNAL OF PERIODONTOLOGY
(2022)
Article
Chemistry, Medicinal
Xin Yang, Long Wang, Jing Zeng, Anguo Wu, Mi Qin, Min Wen, Ting Zhang, Wang Chen, Qibing Mei, Dalian Qin, Jing Yang, Yu Jiang, Jianming Wu
Summary: This study demonstrates that CPM may be a promising thrombopoietic agent for treating chemotherapy and radiation-induced thrombocytopenia.
Article
Cell Biology
Kuang-Chen Hung, Ni Tien, Da-Tian Bau, Chun-Hsu Yao, Chan-Hung Chen, Jiun-Long Yang, Meng-Liang Lin, Shih-Shun Chen
Summary: The aberrant activation of signaling pathways contributes to cancer cells with metabolic reprogramming. Thus, targeting signaling modulators is considered a potential therapeutic strategy for cancer. Subcellular fractionation, coimmunoprecipitation, biochemical analysis, and gene manipulation experiments revealed that decreasing the interaction of KRAS with p110 alpha in lipid rafts with the use of naringenin (NGN), a citrus flavonoid, causes lipid raft-associated phosphatidylinositol 3-kinase (PI3K)-GTP-ras-related C3 botulinum toxin substrate 1 (Rac1)-protein kinase B (Akt)-regulated metabolic dysfunction of glycolysis and mitochondrial oxidative phosphorylation (OXPHOS), leading to apoptosis in human nasopharyngeal carcinoma (NPC) cells.
Article
Environmental Sciences
Ruilong Song, Shuangjiang He, Ying Cao, Yicheng Lu, Yunwen Peng, Hui Zou, Xishuai Tong, Di Ran, Yonggang Ma, Zongping Liu
Summary: Cadmium can damage bone cells and cause osteoporosis. Autophagy plays an important role in the progression of osteoporosis. This study found that cadmium induces autophagy in osteocytes and inhibits the PI3K/AKT/mTOR signaling pathway.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Critical Care Medicine
Chaoyi Zhong, Qingwen Nong, Wenyu Feng, Yugu Pan, Yajun Wu, Xianmin Zeng, Hanwen Li, Xueran Zhong, Feicui Li, Zhiwei Luan, Xing Huang, Kai Luo, Daen Liu, Jun Yao
Summary: Hypertrophic scar is a common pathological scar, and Polyphyllin VII from traditional Chinese medicine can inhibit the proliferation of scar fibroblasts by inducing apoptosis, making it a potential effective drug for treating hypertrophic scars.
Article
Medicine, Research & Experimental
Jirapak Ruttanapattanakul, Nitwara Wikan, Siriporn Okonogi, Mingkwan Na Takuathung, Pensiri Buacheen, Pornsiri Pitchakarn, Saranyapin Potikanond, Wutigri Nimlamool
Summary: Boesenbergia rotunda extract promotes wound healing by stimulating cell proliferation, activating the ERK1/2 and Akt signaling pathways, but does not enhance cell migration. These findings support the potential of BR as a wound-healing promoting agent.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Biochemistry & Molecular Biology
Kejia Wang, Kuo Shen, Fu Han, Xiaozhi Bai, Zhuoqun Fang, Yanhui Jia, Jian Zhang, Yan Li, Weixia Cai, Xujie Wang, Liang Luo, Kai Guo, Hongtao Wang, Xuekang Yang, Huina Wang, Dahai Hu
Summary: Deep second-degree burns heal slowly, and promoting the healing process is a focus of clinical research. This study explored the role and molecular mechanism of sestrin2 in deep second-degree burns as a potential treatment target for burn wounds.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2023)
Article
Multidisciplinary Sciences
Feng Zhi, Bowen Li, Chuanxia Zhang, Fan Xia, Rong Wang, Weihong Xie, Sihui Cai, Dawei Zhang, Ren Kong, Yiqiao Hu, Yilin Yang, Ya Peng, Jun Cui
Summary: NLRP6 enhances the PI3K/AKT pathway by binding and degrading p85 alpha, promoting tumorigenesis. The interaction between NLRP6 and p85 alpha offers a potential therapeutic target for tumor treatment.
NATURE COMMUNICATIONS
(2023)
Article
Nanoscience & Nanotechnology
Zhong Shen, Xiu-Feng Zhang, Hou-Dong Wang, Yan-Yan Yu, Yi-Dian Lei, Jian-Ming Qiu
Summary: The study found that autologous concentrated growth factor (ACGF) can enhance wound healing in rats, and its mechanism may be associated with the activation of the MEK/ERK and PI3K/AKT pathways.
JOURNAL OF BIOMEDICAL NANOTECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Liang Chen, Wenyang Niu, Hong Zang, Yudong Qiu
Summary: DTX3L is highly expressed in pancreatic cancer and its overexpression promotes tumor progression by activating the EGFR dependent FAK/PI3K/Akt pathway. DTX3L also reduces sensitivity to chemotherapy in pancreatic cancer cells. These findings suggest that DTX3L could be a potential therapeutic target for pancreatic cancer treatment.
BIOCHEMICAL GENETICS
(2023)
Article
Food Science & Technology
Lei Bao, Xiaxia Cai, Mingyuan Zhang, Yang Xiao, Jin Jin, Tong Qin, Yong Li
Summary: This study evaluated the effects of BCOP on wound healing and found that it could accelerate the healing process by promoting fibroblast proliferation, migration, and collagen metabolism.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Article
Cell Biology
Yanbo Li, Fengbo Wu, Muke Zhou, Jie Zhou, Shuhui Cui, Jian Guo, Junhao Wu, Li He
Summary: NGF plays a crucial role in mediating autophagy and apoptosis, with the protective effect of NGF being associated with the activation of the PI3K/Akt/mTOR and ERK pathways as well as changes in autophagy-related proteins. ProNGF, on the other hand, promotes autophagy through the ERK pathway and affects apoptosis-related proteins. These findings were confirmed in male SD rats with cerebral ischemia-reperfusion injury, where neurological deficits could be rescued by NGF or exacerbated by proNGF.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2022)
Article
Cell Biology
OEzge Boyacioglu, Elif Bilgic, Cem Varan, Erem Bilensoy, Emirhan Nemutlu, Duygu Sevim, Cetin Kocaefe, Petek Korkusuz
Summary: Therapeutic agents for NSCLC have limited efficacy and may cause serious adverse effects. Cannabinoid ligands, particularly ACPA, have shown promise in inhibiting proliferation and inducing apoptosis in NSCLC cells. Activation of pro-apoptotic pathways and inhibition of key metabolic processes by ACPA suggest its potential as a novel therapy for NSCLC.
CELL DEATH & DISEASE
(2021)
Article
Biochemistry & Molecular Biology
Jia-cheng Xu, Tian-yin Chen, Le-tai Liao, Tao Chen, Quan-lin Li, Jia-xin Xu, Jian-wei Hu, Ping-hong Zhou, Yi-qun Zhang
Summary: Our study revealed that high expression of NETO2 in ESCC patients was associated with tumor staging and lymph node metastasis, promoting ESCC progression through enhancing cell proliferation, suppressing apoptosis, and stimulating tumor growth. Additionally, NETO2 was found to play a crucial role in regulating migration, invasion, and epithelial-mesenchymal transition in ESCC cells. Mechanistically, NETO2 activated ERK, PI3k/AKT, and Nrf2 signaling pathways, with Nrf2 identified as a critical downstream mediator responsible for tumorigenesis. This suggests that NETO2 may serve as a potential therapeutic target or prognostic biomarker for ESCC patients.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Cell Biology
Eyleen Corrales, Ella Levit-Zerdoun, Patrick Metzger, Ralf Mertes, Ariane Lehmann, Julia Munch, Steffen Lemke, Silke Kowar, Melanie Boerries
Summary: This study comprehensively characterized a panel of patient-derived BRAFV600E positive melanoma cell lines and found that a decrease in sensitivity to MAPK/ERK pathway inhibition corresponded with increased migratory potential and the acquisition of stem cell-like properties. Additionally, it was discovered that increased activity of the PI3K/AKT pathway lead to a decreased dependency on MAPK/ERK signaling in melanoma cells.
CELL COMMUNICATION AND SIGNALING
(2022)