Article
Biochemistry & Molecular Biology
Eugenia Veronica Di Brizzi, Annachiara Rocco, Graziella Babino, Dario Buononato, Giuseppe Argenziano, Anna Balato
Summary: The study confirmed the potential of fecal calprotectin levels as a valuable tool for evaluating intestinal inflammation management in psoriatic patients, especially those undergoing biological therapy. The research also found that IL23 inhibitors significantly reduced calprotectin levels after treatment, whereas anti-IL17 drugs did not have the same effect.
Article
Medicine, General & Internal
Shengnan Wang, Shijian Miao, Xiaoxia Qiu, Jie Wu, Yuhuan Wang
Summary: This study aimed to assess the capability of fecal calprotectin (FC) in predicting small bowel capsule endoscopy (SBCE) findings in pediatric patients with known Crohn's disease (CD). The study found that FC was weakly correlated with small bowel inflammation and can be used as a predictor of small bowel mucosal inflammation.
Review
Medicine, General & Internal
Marta Fortuny, Maria-Rosa Sarrias, Maria Torner, Ignacio Iborra, Ariadna Clos, Alba Ardevol, Ramon Bartoli, Rosa M. Morillas, Eugeni Domenech, Helena Masnou
Summary: The article summarizes the current evidence regarding the diagnostic and prognostic utility of calprotectin in ACLD.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Biochemistry & Molecular Biology
Debora Mariarita d'Angelo, Marina Attanasi, Giulia Di Donato, Giuseppe Lapergola, Mariarosaria Flacco, Francesco Chiarelli, Emma Altobelli, Luciana Breda
Summary: The study investigates the potential role of serum calprotectin as a biomarker for disease activity and flare/remission in patients with juvenile idiopathic arthritis (JIA). The results suggest that serum calprotectin has a dual role in predicting future relapse and treatment response, which is important for therapeutic decisions and management during follow-up.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Martina Orfei, Marco Gasparetto, Kai O. Hensel, Florian Zellweger, Robert B. Heuschkel, Matthias Zilbauer
Summary: The study evaluated the diagnostic value of faecal calprotectin (FCP) levels in children and their referral pathways. Results showed that children with FCP < 600μg/g and without symptoms suggestive of IBD are unlikely to have IBD. A guideline for specialist referrals is proposed for patients with FCP > 50μg/g but no IBD.
Review
Medicine, General & Internal
Eliza Lezyk-Ciemniak, Magdalena Tworkiewicz, Dominika Wilczynska, Anna Szaflarska-Poplawska, Aneta Krogulska
Summary: The article summarizes the use of fecal calprotectin (FC) in the diagnosis and monitoring of pediatric inflammatory bowel disease (IBD), emphasizing FC's role primarily in monitoring disease activity, predicting relapse, monitoring therapy efficacy, and postoperative relapses.
MEDICAL PRINCIPLES AND PRACTICE
(2021)
Article
Pediatrics
Dominika Lendvai-Emmert, Vanessza Emmert, Alexandra Makai, Katalin Fusz, Viktoria Premusz, Kata Eklics, Patricia Sarlos, Peter Toth, Krisztina Amrein, Gergely Toth
Summary: This study suggests that fecal calprotectin (FC) can serve as an objective marker for confirming the diagnosis of cow's milk protein allergy (CMPA). Significant improvement in clinical symptoms and FC levels can only be expected after strictly following an elimination diet.
FRONTIERS IN PEDIATRICS
(2022)
Article
Pediatrics
Manar Matar, Rachel Levi, Maya Zvuloni, Raanan Shamir, Amit Assa
Summary: This study aimed to assess the effect of anti-TNF alpha therapy on fecal calprotectin (FC) levels in children with inflammatory bowel disease (IBD). The results showed that the majority of patients achieved improvement in FC levels within a short period of time, but normalization of FC in responders required almost one year. The shorter the time from diagnosis to treatment, the faster the improvement in FC levels.
PEDIATRIC RESEARCH
(2023)
Review
Medicine, General & Internal
Angela Saviano, Marcello Candelli, Christian Zanza, Andrea Piccioni, Alessio Migneco, Veronica Ojetti
Summary: Fecal calprotectin is a sensitive marker of gastrointestinal inflammation, and it has clinical utility in intestinal and extraintestinal diseases. Recent evidence suggests its association with dermatological, rheumatic, and neurological diseases, as well as its role in SARS-CoV-2 infection.
MEDICINA-LITHUANIA
(2022)
Article
Medicine, General & Internal
Edyta Szymanska, Aldona Wierzbicka, Maciej Dadalski, Jaroslaw Kierkus
Summary: Increased intestinal permeability is associated with inflammatory bowel diseases, and fecal ZRP levels may serve as a noninvasive biomarker of disease activity. The study found a slight correlation between ZRP levels and disease activity in CD patients, but not in UC patients. Furthermore, fecal ZRP strongly correlated with FCP levels.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Multidisciplinary Sciences
Jonathan Y. Xia, Chelsea Hepler, Peter Tran, Nathan J. Waldeck, Joseph Bass, Arthur Prindle
Summary: Inflammatory bowel disease (IBD) is a group of autoimmune diseases with unpredictable flares and invasive surveillance methods. Engineered probiotics have the potential to detect IBD biomarkers and provide noninvasive disease activity monitoring.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Acoustics
Gianfranco Vallone, Paolo Pizzicato, Eugenio Rossi, Luca Brunese
Summary: Ultrasound is the preferred imaging technique for chronic inflammatory bowel diseases (IBD) in children, as it is noninvasive, free of radiation, and cost-effective, with a good negative predictive value for IBD.
ULTRASCHALL IN DER MEDIZIN
(2022)
Article
Medical Laboratory Technology
Juozas Butenas, Ruth M. Ayling
Summary: This study evaluated the performance of a new OC-FCa calprotectin assay for the diagnosis of inflammatory bowel disease (IBD) and determined a suitable cutoff value. The results showed that at a cutoff of 600 μg/g, the assay had a sensitivity of 91.8% and specificity of 79.3% for diagnosing IBD.
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2022)
Review
Medical Laboratory Technology
Jennifer Murray, Klaartje B. Kok, Ruth M. Ayling
Summary: Inflammatory bowel disease (IBD) is a group of chronic conditions characterized by inflammation of the gastrointestinal tract. Endoscopy is the gold standard for diagnosis of IBD, but it is invasive and costly. Fecal calprotectin has been proven to be an accurate surrogate marker for intestinal inflammation in IBD.
CLINICAL CHEMISTRY
(2023)
Review
Pediatrics
Grigorios Chatziparasidis, Ahmad Kantar
Summary: Calprotectin is a non-covalent heterodimer formed by S100A8 and S100A9 subunits, playing an important role in human innate immunity by chelating metal ions essential for bacterial development. It acts as an alarmin controlling the inflammatory response and can be used as a biomarker in inflammatory diseases, especially in pediatric respiratory diseases. Despite being discovered almost 40 years ago, its potential as a biomarker in various pediatric respiratory diseases is still underutilized.
Review
Peripheral Vascular Disease
Ioannis D. Kostakis, Ioannis Loukopoulos
Summary: A systematic review comparing bovine carotid artery grafts with polytetrafluoroethylene grafts for haemodialysis vascular access found that both types of grafts have similar short-term and long-term outcomes. However, bovine carotid artery grafts may have an advantage in terms of lower graft infection rates and fewer interventions needed per patient-year.
JOURNAL OF VASCULAR ACCESS
(2021)
Article
Biochemistry & Molecular Biology
Eleni Chontzopoulou, Christina D. Papaemmanouil, Maria Chatziathanasiadou, Dimitrios Kolokouris, Sofia Kiriakidi, Athina Konstantinidi, Ioanna Gerogianni, Theodore Tselios, Ioannis K. Kostakis, Evangelia D. Chrysina, Dimitra Hadjipavlou-Litina, Demeter Tzeli, Andreas G. Tzakos, Thomas Mavromoustakos
Summary: The study indicates that aspartame could potentially inhibit LOX-1 and block its biological response, serving as a novel starting point for drug design against LOX enzyme. Various in silico and experimental studies were conducted to evaluate the potency of natural and artificial sweeteners in inhibiting the lipoxygenase enzyme, providing insight into their potential therapeutic applications.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2022)
Article
Economics
Ioannis Kostakis, Konstantinos P. Tsagarakis
Summary: The empirical study explores the impact of socioeconomic characteristics on the circular economy, revealing positive effects from factors such as economic wealth, fertility rate, environmental taxes, and R&D expenditures on materials recycling and circularity rates in the EU. Urbanization also has a positive but nonlinear effect on recycling and circularity rates. These findings can be valuable for policymakers and managers looking to implement policies to increase recycling and circularity in the EU and beyond.
ANNALS OF REGIONAL SCIENCE
(2022)
Article
Green & Sustainable Science & Technology
Ioannis Kostakis, Sarantis Lolos
Summary: This study examines the behaviour of residential electricity demand in Greece from 2009 to 2018, finding that demand is price and income inelastic and that household size and education level are important determinants. As electricity use increases, demand becomes less responsive to income and more responsive to prices.
ENERGY ECOLOGY AND ENVIRONMENT
(2022)
Article
Green & Sustainable Science & Technology
Ioannis Kostakis, Konstantinos P. Tsagarakis
Summary: This study analyzes the relationship between entrepreneurship, innovation, socio-economic development, and circularity progress in the European Union countries. The empirical findings suggest that entrepreneurship, innovation, and socio-economic development significantly affect the circularity rate, while polluting entrepreneurship has a negative association with circularity. Research and development and economic growth also have positive impacts on circularity, and the human development index is important in the circularity process.
JOURNAL OF CLEANER PRODUCTION
(2022)
Article
Biochemistry & Molecular Biology
Nikolaos Kritikos, Aikaterini Iliou, Amalia D. Kalampaliki, Evangelos Gikas, Ioannis K. Kostakis, Benoit Y. Michel, Yannis Dotsikas
Summary: In this study, a novel xanthone analogue was used for the first time to derivatize the colorless analyte pregabalin, enabling the reduction of analysis time and achieving high yield and accuracy through optimized reaction conditions.
Editorial Material
Economics
Josep-Maria Arauzo-Carod, Ioannis Kostakis, Konstantinos P. Tsagarakis
Summary: Circular Economy and Sustainability are important challenges for policymakers, producers, and consumers. Circular Economy processes can minimize waste generation and have the potential to combat the negative effects of climate change. Public policies supporting the Circular Economy should be designed at the lowest levels of public administrations, providing opportunities for regional governments to implement and monitor these policies. This special issue provides a rich body of work for further research on the nexus between Circularity and Sustainability.
ANNALS OF REGIONAL SCIENCE
(2022)
Article
Chemistry, Organic
Amalia D. Kalampaliki, Sofia Kanellopoulou, Ioannis K. Kostakis
Summary: Pyrano [3,4-b]indol-1(9H)-ones and indolo [2,3-c]coumarins are important classes of heterocyclic compounds with versatile biological activities. Here, we describe a straightforward and scalable synthesis method, and the compound is fully characterized by means of H-1 and C-13 NMR spectra.
Article
Chemistry, Organic
Konstantinos Paraskevas, Christos Iliopoulos-Tsoutsouvas, Eleftheria A. Georgiou, Ioannis K. Kostakis
Summary: Xanthenes and benzothiazoles are important heterocyclic compounds with versatile biological activities. This study presents a straightforward and scalable synthesis of a thiazole-fused xanthone compound. The thiazole ring was synthesized using Appel's salt in a six-step approach, and the product was fully characterized using 1H and 13C NMR spectroscopy.
Article
Genetics & Heredity
Paraskevi Karousi, Christos K. Kontos, Panagiota Papakotsi, Ioannis K. Kostakis, Alexios-Leandros Skaltsounis, Andreas Scorilas
Summary: This study found that oleuropein and oleocanthal can inhibit the proliferation of triple-negative breast cancer (TNBC) cells and significantly alter the expression profile of TNBC cells. These compounds may have therapeutic benefits for TNBC through their effects on multiple pathways associated with TNBC.
FUNCTIONAL & INTEGRATIVE GENOMICS
(2023)
Article
Biochemistry & Molecular Biology
Elizabeth Fragopoulou, Katerina Gkotsi, Filio Petsini, Katerina Gioti, Amalia D. D. Kalampaliki, George Lambrinidis, Ioannis K. K. Kostakis, Roxane Tenta
Summary: Resveratrol is a natural compound with various health benefits, including antioxidant, anti-inflammatory, and anti-platelet properties. However, its low bioavailability limits its effectiveness. This study synthesized methoxy derivatives of resveratrol and evaluated their effects on platelet function. Some derivatives showed superior anti-platelet activity compared to the original compound, indicating their potential as anti-platelet agents.
Article
Biochemistry & Molecular Biology
Maria Karelou, Dionysis Kampasis, Amalia D. Kalampaliki, Leentje Persoons, Andreas Kraemer, Dominique Schols, Stefan Knapp, Steven De Jonghe, Ioannis K. Kostakis, Sotiris S. Nikolaropoulos
Summary: Sixteen new 2-substituted quinazolines were synthesized and evaluated for their anti-proliferative activity against multiple cancer cell lines. Compound 17 showed remarkable activity against the majority of tested cell lines.
Meeting Abstract
Pediatrics
Ioannis Kostakis, Pankaj Chandak, Sergio Assia--Zamora, Petrut Gogalniceanu, Ioannis Loukopoulos, Francis Calder, Jelena Stojanovic, Nicos Kessaris
PEDIATRIC TRANSPLANTATION
(2022)
Review
Oncology
Moustafa Allam, Camila Hidalgo Salinas, Nikolaos Machairas, Ioannis D. Kostakis, Jennifer Watkins, Giuseppe Kito Fusai
Summary: Solid pseudopapillary neoplasms of the pancreas are rare tumors with low malignant potential, usually affecting young females. Surgical resection is the main treatment with good prognosis.
JOURNAL OF GASTROINTESTINAL CANCER
(2022)
Article
Oncology
Victoria Psomiadou, Anastasia Prodromidou, Elpis Galati, Ioannis D. Kostakis, Athanasios Maliaros, Ioannis Mamais, Nikolaos Blontzos, Fotios Lefkopoulos, Christos Iavazzo, George Vorgias
Summary: Inflammatory biomarker ratios can help distinguish malignant ovarian tumors from benign ones. Patients with malignant tumors had significantly higher NLR and PLR ratios, lower LMR ratio, as well as higher lymphocyte and platelet counts compared to those with benign tumors.
WSPOLCZESNA ONKOLOGIA-CONTEMPORARY ONCOLOGY
(2021)
