Extremophilic SHMTs: From Structure to Biotechnology

Glycine consumption and mitochondrial serine hydroxymethyltransferase in cancer cells: The heme connection

(2013) Martino L. di Salvo et al.   MEDICAL HYPOTHESES

Alanine racemase from Tolypocladium inflatum: A key PLP-dependent enzyme in cyclosporin biosynthesis and a model of catalytic promiscuity

(2012) Martino L. di Salvo et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Serine Hydroxymethyltransferase from the Cold Adapted Microorganism Psychromonas ingrahamii: A Low Temperature Active Enzyme with Broad Substrate Specificity

(2012) Sebastiana Angelaccio et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

In silico and in vitro validation of serine hydroxymethyltransferase as a chemotherapeutic target of the antifolate drug pemetrexed

(2011) Frederick Daidone et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Chemogenomics of pyridoxal 5′-phosphate dependent enzymes

(2011) Ratna Singh et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Open conformation of human DOPA decarboxylase reveals the mechanism of PLP addition to Group II decarboxylases

(2011) G. Giardina et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural adaptation of extreme halophilic proteins through decrease of conserved hydrophobic contact surface

(2011) Alessandro Siglioccolo et al.   BMC STRUCTURAL BIOLOGY

Preparation of optically active β-hydroxy-α-amino acid by immobilized Escherichia coli cells with serine hydroxymethyl transferase activity

(2010) Gen-Hai Zhao et al.   AMINO ACIDS

Alkaline pH-dependent differential unfolding characteristics of mesophilic and thermophilic homologs of dimeric serine hydroxymethyltransferase

(2010) Anant Narayan Bhatt et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

“Cold spots” in protein cold adaptation: Insights from normalized atomic displacement parameters (B′-factors)

(2010) Alessandro Siglioccolo et al.   BIOPHYSICAL CHEMISTRY

Erratum to ‘Nature and nurture in protein folding and binding’ [Curr Opin Struct Biol 2010, 20:1–2]

(2010) Laura Itzhaki et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Role of a Conserved Active Site Cation−π Interaction inEscherichia coliSerine Hydroxymethyltransferase

(2009) Mirella Vivoli et al.   BIOCHEMISTRY

Structural adaptation of serine hydroxymethyltransferase to low temperatures

(2009) Alessandro Siglioccolo et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Structural and functional studies ofBacillus stearothermophilusserine hydroxymethyltransferase: the role of Asn341, Tyr60and Phe351in tetrahydrofolate binding

(2008) Vinitha R. Pai et al.   BIOCHEMICAL JOURNAL

Serine Hydroxymethyl Transferase fromStreptococcus thermophilus andL-Threonine Aldolase fromEscherichia coli as Stereocomplementary Biocatalysts for the Synthesis of β-Hydroxy-α,ω-diamino Acid Derivatives

(2008) Mariana L. Gutierrez et al.   CHEMISTRY-A EUROPEAN JOURNAL

Structural adaptation of the subunit interface of oligomeric thermophilic and hyperthermophilic enzymes

(2008) Elisa Maugini et al.   COMPUTATIONAL BIOLOGY AND CHEMISTRY