Article
Immunology
Carlos A. Alvarez, Emily Qian, Leandre M. Glendenning, Kalob M. Reynero, Emily N. Kukan, Brian A. Cobb
Summary: Asthma, a chronic inflammatory disease characterized by leukocyte infiltration and tissue remodeling, is associated with increased glycan fucosylation in airway epithelial cells. This modification is important for the recruitment of eosinophils and neutrophils.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Victoria A. Ptasinski, John Stegmayr, Maria G. Belvisi, Darcy E. Wagner, Lynne A. Murray
Summary: Idiopathic pulmonary fibrosis (IPF) is a fatal interstitial lung disease initiated by repeated epithelial injuries, leading to abnormal wound healing responses. Targeting the regenerative capacity of lung epithelium is crucial for developing novel therapies for IPF, which involves coordinated cross-talk among multiple cell types and reestablishment of a normal extracellular matrix environment.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2021)
Article
Environmental Sciences
Lodinikki Lemoy Davis, Walessa Alana Braganca Aragao, Gessica de Oliveira Lopes, Luciana Guimaraes Eiro, Alexandre Rodrigues Freire, Felippe Bevilacqua Prado, Ana Claudia Rossi, Allan da Silva Cruz, Kelly das Gracas Fernandes Dantas, Alan Rodrigo Leal Albuquerque, Simone Patricia Aranha Paz, Romulo Simoes Angelica, Rafael Rodrigues Lima
Summary: The study found that long-term exposure to lead can alter the microstructure of the alveolar bone, resulting in changes in bone volume, number of trabeculae, trabecular thickness, and trabecular space.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Review
Cell Biology
Jessica L. Christenson, Michelle M. Williams, Jennifer K. Richer
Summary: The alveolar epithelium plays a significant role in the progression of metastatic cancer, not only influencing the site of metastasis within the lungs but also impacting metastatic progression through interactions with surrounding cells.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2022)
Review
Physiology
Jennifer M. K. Nguyen, Douglas N. Robinson, Venkataramana K. Sidhaye
Summary: COPD is a respiratory disease characterized by breathing difficulties, with current treatments focusing on symptom relief rather than cure. Emerging research on upstream pathways such as mitochondrial function, cytoskeletal structure, and airway hydration may provide breakthroughs in COPD therapeutics.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2021)
Article
Medicine, Research & Experimental
Xin Wang, Xianglin Hou, Yannan Zhao, Ruiming Zhao, Jianwu Dai, Huaping Dai, Chen Wang
Summary: Chronic obstructive pulmonary disease (COPD) is a highly prevalent and fatal disease for which there is currently no effective treatment. This study investigated the timing of sustained release FGF2 system administration in a mouse model of lung injury induced by porcine pancreatic elastase (PPE). The results suggest that early intervention with CBD-FGF2 can prevent and repair elastase-induced lung injury by suppressing inflammation and promoting alveolar epithelial recovery, while late therapeutic administration has limited efficacy against established emphysema.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Biology
Baishakhi Ghosh, Jeffrey Loube, Shreeti Thapa, Hurley Ryan, Erin Capodanno, Daniel Chen, Carter Swaby, Si Chen, Saborny Mahmud, Mirit Girgis, Kristine Nishida, Linyan Ying, Pratulya Pragadaraju Chengala, Ethan Tieng, Michael Burnim, Ara Wally, Debarshi Bhowmik, Michael Zaykaner, Bonnie Yeung-Luk, Wayne Mitzner, Shyam Biswal, Venkataramana K. Sidhaye
Summary: The integrity of lung epithelial cells is crucial for lung health, and the loss of the key protein E-cadherin is observed in patients with chronic obstructive pulmonary disease (COPD). This study demonstrates that the loss of E-cadherin is causal to the development of chronic lung disease. The specific loss of E-cadherin in alveolar epithelial and airway ciliated cells leads to different lung pathologies.
COMMUNICATIONS BIOLOGY
(2022)
Article
Cell Biology
Jian Deng, Shao-Hua Wang, Xue-Mei Zheng, Zan-Mei Tang
Summary: The study showed that CGRP can promote cell viability and inhibit hyperoxia-induced transdifferentiation of AECII, reducing oxidative injury and inflammation. Additionally, CGRP activates the Notch signaling pathway, promoting structural and functional regeneration.
Article
Biology
Yubin Lee, Jaeseung Song, Yeonbin Jeong, Eunyoung Choi, Chulwoo Ahn, Wonhee Jang
Summary: This study used meta-analysis to reveal the single-cell mechanisms underlying the pathogenesis of chronic obstructive pulmonary disease (COPD). Different cell types were observed in COPD patients compared to healthy subjects, and monocytes, mast cells, and alveolar type 2 cells were identified as etiological cell types associated with COPD.
COMPUTERS IN BIOLOGY AND MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Marilia Sanches Santos Rizzo Zuttion, Sarah Kathryn Littlehale Moore, Peter Chen, Andrew Kota Beppu, Jaime Lynn Hook
Summary: This review examines the role of the alveolar epithelium in maintaining efficient gas exchange and its involvement in the development of acute respiratory distress syndrome (ARDS). The focus is on virus-induced lung injury and the coordination of injury-induced lung inflammation by the alveolar epithelium, as well as maladaptive lung responses leading to ARDS and pathological lung remodeling.
Article
Medicine, Research & Experimental
Yue Chen, Hua Wang, Qiudong Yang, Wenhua Zhao, Yuyi Chen, Qiaoqi Ni, Wenlei Li, Jiali Shi, Wei Zhang, Lu Li, Yan Xu, Hengwei Zhang, Dengshun Miao, Lianping Xing, Wen Sun
Summary: This study comprehensively revealed the complexities of the molecular components in the osteoimmunology microenvironment of periodontal tissues at the single-cell level using scRNA-seq. Differences in specific cell types were observed in patients with periodontitis, with significant differentiation characteristics observed in certain cell types after initial periodontal therapy.
Article
Cell Biology
Marija Gredic, Vinita Sharma, Stefan Hadzic, Cheng-Yu Wu, Oleg Pak, Baktybek Kojonazarov, Julia Duerr, Marcus A. A. Mall, Andreas Guenther, Ralph T. T. Schermuly, Friedrich Grimminger, Werner Seeger, Simone Kraut, Natascha Sommer, Norbert Weissmann
Summary: This study aimed to investigate the effect of iNOS gene deletion on elastase-induced emphysema in mice. The results showed that iNOS gene deletion did not produce significant therapeutic effects on elastase-induced lung emphysema and pulmonary hypertension. Therefore, this study suggests that iNOS expression in pulmonary vascular or stromal cells might play a critical role in lung regeneration in emphysema.
Article
Physiology
Corynn N. Appolonia, Kaelin M. Wolf, Charles N. Zawatsky, Resat Cinar
Summary: Heavy alcohol drinking has negative health effects on multiple organs, including the lungs. The NIAAA alcohol feeding model can be used to study alcohol-induced lung injury and inflammation.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Rossana Visigalli, Bianca Maria Rotoli, Francesca Ferrari, Maria Di Lascia, Benedetta Riccardi, Paola Puccini, Valeria Dall'Asta, Amelia Barilli
Summary: In this study, the expression and activity of ABC transporters in human alveoli were analyzed. The results showed that MRP1 was the only transporter expressed and functional at the basolateral side, while the other studied transporters were not expressed on the apical membrane. This suggests the presence of unidentified transporters involved in drug efflux from alveolar epithelium.
Article
Chemistry, Multidisciplinary
Claudia Meindl, Markus Absenger-Novak, Ramona Jeitler, Eva Roblegg, Eleonore Froehlich
Summary: The toxicity of inhaled nanoparticles was assessed using air-liquid interface cultures of respiratory cells and reconstructed bronchial and alveolar tissues. The results showed no significant adverse effects on the bronchial and alveolar models when exposed to nanoparticles at doses corresponding to the maximum estimated lifetime exposure of workers, except for a slight increase in interleukin 6 secretion in the alveolar model.
Article
Cell & Tissue Engineering
Udit Agarwal, Amanda W. Smith, Kristin M. French, Archana V. Boopathy, Alex George, David Trac, Milton E. Brown, Ming Shen, Rong Jiang, Janet D. Fernandez, Brian E. Kogon, Kirk R. Kanter, Baahaldin Alsoufi, Mary B. Wagner, Manu O. Platt, Michael E. Davis
STEM CELLS TRANSLATIONAL MEDICINE
(2016)
Article
Biotechnology & Applied Microbiology
Mario D. Martinez, David Q. Trac, Milton E. Brown, Kevin O. Maher, Michael E. Davis
Article
Biochemistry & Molecular Biology
Charles A. Downs, Lisa H. Kreiner, David Q. Trac, My N. Helms
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2013)
Article
Multidisciplinary Sciences
Charles A. Downs, David Q. Trac, Lisa H. Kreiner, Amity F. Eaton, Nicholle M. Johnson, Ann Brown, My N. Helms
Article
Cardiac & Cardiovascular Systems
David Trac, Joshua T. Maxwell, Milton E. Brown, Chunhui Xu, Michael E. Davis
CIRCULATION RESEARCH
(2019)
Article
Cell & Tissue Engineering
Joshua T. Maxwell, David Trac, Ming Shen, Milton E. Brown, Michael E. Davis, Myra S. Chao, Krittin J. Supapannachart, Carly A. Zaladonis, Emily Baker, Martin L. Li, Jennifer Zhao, Daniel Jacobs
Article
Cell & Tissue Engineering
David Trac, Jessica R. Hoffman, Sruti Bheri, Joshua T. Maxwell, Manu O. Platt, Michael E. Davis
STEM CELLS TRANSLATIONAL MEDICINE
(2019)
Article
Cardiac & Cardiovascular Systems
Junyu Yang, Milton E. Brown, Hanshuo Zhang, Mario Martinez, Zhihua Zhao, Srishti Bhutani, Shenyi Yin, David Trac, Jianzhong Jeff Xi, Michael E. Davis
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2017)
Article
Physiology
David Trac, Bingchen Liu, Alan C. Pao, Sheela V. Thomas, Michael Park, Charles A. Downs, He-Ping Ma, My N. Helms
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2013)