Article
Urology & Nephrology
Francesco Claps, Maaike W. van de Kamp, Roman Mayr, Peter J. Bostrom, Shahrokh F. Shariat, Katrin Hippe, Simone Bertz, Yann Neuzillet, Joyce Sanders, Wolfgang Otto, Michiel S. van Der Heijden, Michael A. S. Jewett, Robert Stoehr, Alexandre R. Zlotta, Carlo Trombetta, Markus Eckstein, Laura S. Mertens, Maximilian Burger, Yanish Soorojebally, Bernd Wullich, Riccardo Bartoletti, Francois Radvanyi, Nicola Pavan, Nanour Sirab, M. Carmen Mir, Damien Pouessel, Theo H. van Der Kwast, Arndt Hartmann, Yair Lotan, Rossana Bussani, Yves Allory, Bas W. G. van Rhijn
Summary: The study aims to evaluate variant histologies (VHs) for disease-specific survival (DSS) in patients with invasive urothelial bladder cancer (BCa) undergoing radical cystectomy (RC). The results showed that compared to pure urothelial carcinoma, clear-cell, plasmacytoid, small-cell, and sarcomatoid VHs were associated with worse DSS, while lymphoepithelioma-like VH showed a DSS benefit. Accurate pathological diagnosis can ensure tailored counselling for patients who require more intensive management.
Article
Oncology
Stefano Tappero, Andrea Panunzio, Lukas Hohenhorst, Cristina Cano Garcia, Francesco Barletta, Mattia Piccinelli, Zhe Tian, Stefano Parodi, Alessandro Antonelli, Markus Graefen, Felix K. H. Chun, Alberto Briganti, Ottavio De Cobelli, Fred Saad, Shahrokh F. Shariat, Nazareno Suardi, Marco Borghesi, Carlo Terrone, Pierre I. Karakiewicz
Summary: The effect of radical cystectomy (RC) on cancer-specific mortality (CSM) is uncertain in non-metastatic sarcomatoid bladder cancer (SBC) patients. This study aimed to evaluate the benefit of RC in SBC patients and compare it with urothelial bladder cancer (UCB).
Article
Urology & Nephrology
Keiichiro Mori, Victor M. Schuettfort, Satoshi Katayama, Ekaterina Laukhtina, Benjamin Pradere, Fahad Quhal, Reza Sari Motlagh, Hadi Mostafaei, Nico C. Grossmann, Pawel Rajwa, Frederik Koenig, Abdulmajeed Aydh, Francesco Soria, Marco Moschini, Pierre Karakiewicz, Yair Lotan, Douglas Scherr, Martin Haydter, Peter Nyirady, Jeremy Y. C. Teoh, Shin Egawa, Eva Comperat, Shahrokh F. Shariat
Summary: This study investigated the predictive and prognostic role of the angiogenesis-related marker VEGF in patients with bladder cancer, and found that elevated plasma VEGF levels were associated with worse survival outcomes.
EUROPEAN UROLOGY FOCUS
(2022)
Article
Oncology
Aleksander Slusarczyk, Piotr Zapala, Tomasz Piecha, Lukasz Zapala, Tomasz Borkowski, Piotr Radziszewski
Summary: The study found that patients who underwent radical nephroureterectomy for upper urinary tract urothelial cancer after radical cystectomy experienced poor overall survival and cancer-specific survival, with most surgeries being performed for locally advanced tumors. Independent risk factors for worse survival included UTUC T stage, presence of metastasis, and male gender.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Ekaterina Laukhtina, Victor M. Schuettfort, David D. Andrea, Benjamin Pradere, Keiichiro Mori, Fahad Quhal, Reza Sari Motlagh, Hadi Mostafaei, Satoshi Katayama, Nico C. Grossmann, Pawel Rajwa, Flora Zeinler, Mohammad Abufaraj, Marco Moschini, Kristin Zimmermann, Pierre Karakiewicz, Harun Fajkovic, Douglas Scherr, Eva Comperat, Peter Nyirady, Michael Rink, Dmitry Enikeev, Shahrokh F. Shariat
Summary: Elevated preoperative plasma endoglin levels are associated with adverse pathological features and survival outcomes in patients with urothelial carcinoma of the bladder, indicating its potential as a predictor for intensified therapy benefit.
MOLECULAR CARCINOGENESIS
(2022)
Article
Oncology
Keiichiro Mori, Victor M. Schuettfort, Satoshi Katayama, Ekaterina Laukhtina, Benjamin Pradere, Fahad Quhal, Reza Sari Motlagh, Hadi Mostafaei, Nico C. Grossmann, Pawel Rajwa, Jeremy Yc Teoh, Irene Resch, Harun Fajkovic, Marco Moschini, David D'andrea, Mohammad Abufaraj, Pierre Karakiewicz, Yair Lotan, Douglas Scherr, Shin Egawa, Eva Comperat, Shahrokh F. Shariat
Summary: Elevated plasma VCAM-1 levels are associated with aggressive UCB disease features and can be used as a biomarker to identify patients who may benefit from intensified/multimodal therapy. Adding VCAM-1 to predictive models significantly improves their discriminatory ability. VCAM-1 can also be used to refine personalized clinical decision-making.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Article
Multidisciplinary Sciences
Zai-Lin Sheu, Chi-Ping Huang, Chao-Hsiang Chang, Chung-Hsin Chen, Jian-Hua Hong, Han-Yu Weng, Ta-Yao Tai, Shiu-Dong Chung, Chi-Wen Lo, Thomas Y. Hsueh, Yao-Chou Tsai, Yuan-Hong Jiang, Bing-Juin Chiang, Yung-Tai Chen, Jen-Tai Lin, Wei-Yu Lin, Yeong-Chin Jou, Jen-Shu Tseng, Chia-Chang Wu, Wen-Jeng Wu, Hsin-Chih Yeh
Summary: For patients with multifocal UTUC, tumor distribution does not impact cancer-specific outcomes, but synchronous lesions are associated with a higher rate of bladder recurrence.
SCIENTIFIC REPORTS
(2021)
Article
Oncology
Stefano Tappero, Francesco Barletta, Mattia Luca Piccinelli, Cristina Cano Garcia, Reha-Baris Incesu, Simone Morra, Lukas Scheipner, Zhe Tian, Stefano Parodi, Paolo Dell'Oglio, Alberto Briganti, Ottavio de Cobelli, Felix K. H. Chun, Markus Graefen, Vincenzo Mirone, Sascha Ahyai, Fred Saad, Shahrokh F. Shariat, Nazareno Suardi, Marco Borghesi, Carlo Terrone, Pierre I. Karakiewicz
Summary: This study evaluated the association between radical cystectomy (RC) and cancer-specific mortality (CSM) in patients with adenocarcinoma of the bladder (ACB), and directly compared the survival advantage of RC between ACB and urothelial bladder cancer (UBC). The results showed that RC was associated with lower CSM in ACB patients, regardless of stage, and the magnitude of this survival advantage was greater in ACB than in UBC.
UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS
(2023)
Article
Oncology
Kenneth Softness, Sumedh Kaul, Aaron Fleishman, Jason Efstathiou, Joaquim Bellmunt, Simon P. Kim, Ruslan Korets, Peter Chang, Andrew Wagner, Aria F. Olumi, Boris Gershman
Summary: In this study, the comparative effectiveness of radical cystectomy (RC) and trimodality therapy (TMT) for muscle-invasive bladder cancer was evaluated using observational data. The results showed no statistically significant difference in overall survival (OS) between RC and TMT. However, when examining heterogeneity of treatment effects, RC appeared to be associated with improved OS only for patients with cT3 disease.
UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS
(2022)
Article
Oncology
Jie Gao, Yingxin Shi, Diansheng Zhou, Yu Zhang, Dawei Tian, Changli Wu
Summary: Sarcopenia is an independent predictor for venous thromboembolism (VTE) in patients undergoing radical cystectomy for bladder cancer, increasing the risk of VTE. The occurrence of VTE is related to older age, higher proportion of diabetes, and lower level of serum albumin.
SUPPORTIVE CARE IN CANCER
(2022)
Article
Immunology
Jindong Zhang, Liangdong Song, Huixuan Zhu, Qinyuan Liu, Delin Wang
Summary: This study found that bladder urothelial carcinoma patients who tested positive for PD-L1 in tumor cells had a poor prognosis after radical cystectomy and removal of pelvic lymph nodes (RC-PLND), suggesting that PD-1 or PD-L1 inhibitors could be used as adjuvant medication for these patients.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, General & Internal
Rocco Simone Flammia, Antonio Tufano, Francesco Chierigo, Christoph Wurnschimmel, Benedikt Hoeh, Gabriele Sorce, Zhen Tian, Umberto Anceschi, Costantino Leonardo, Francesco Del Giudice, Carlo Terrone, Antonio Giordano, Andrea Morrione, Fred Saad, Shahrokh F. Shariat, Alberto Briganti, Francesco Montorsi, Felix K. H. Chun, Michele Gallucci, Pierre I. Karakiewicz
Summary: Female sex in patients with non-urothelial variant-histology bladder cancer treated with comprehensive radical cystectomy is associated with more advanced stage and worse survival.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Urology & Nephrology
Ekaterina Laukhtina, Axelle Boehm, Benoit Peyronnet, Carlo Andrea Bravi, Jose Batista Da Costa, Francesco Soria, David D'Andrea, Pawel Rajwa, Fahad Quhal, Takafumi Yanagisawa, Frederik Koenig, Hadi Mostafaei, Dmitry Enikeev, Alexandre Ingels, Gregory Verhoest, Frederiek D'Hondt, Alexandre Mottrie, Steven Joniau, Hendrik Van Poppel, Alexandre de la Taille, Karim Bensalah, Franck Bruyere, Shahrokh F. Shariat, Benjamin Pradere
Summary: Through evaluating the impact of urethrectomy on patients undergoing radical cystectomy for non-metastatic urothelial carcinoma, we found that this procedure seems to benefit only high-risk patients for urethral recurrence.
WORLD JOURNAL OF UROLOGY
(2022)
Article
Oncology
Maheetha Bharadwaj, Sumedh Kaul, Aaron Fleishman, Ruslan Korets, Peter Chang, Andrew Wagner, Simon Kim, Joaquim Bellmunt, Irving Kaplan, Aria F. Olumi, Boris Gershman
Summary: Observational analyses emulating a completed randomized trial suggest that adjuvant chemotherapy following radical cystectomy may improve overall survival in locally advanced bladder cancer patients. The results were consistent across baseline patient and tumor characteristics.
UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS
(2022)
Article
Urology & Nephrology
Luca Afferi, Chiara Lonati, Francesco Montorsi, Alberto Briganti, Andrea Necchi, Andrea Mari, Andrea Minervini, Riccardo Campi, Ettore di Trapani, Ottavio de Cobelli, R. Jeffrey Karnes, Mohamed Ahmed, M. Carmen Mir, Maria Asuncion Algarra, Michael Rink, Stefania Zamboni, Claudio Simeone, Wojciech Krajewski, Evanguelos Xylinas, Francesco Soria, Kees Hendricksen, Sarah Einerhand, Agostino Mattei, Roberto Carando, Mathieu Roumiguie, Anne Sophie Bajeot, Peter C. Black, Shahrokh F. Shariat, Marco Moschini
Summary: This retrospective study analyzed the clinical data of 1057 patients with pN1-3 cM0 BCa and found that carboplatin-based ACT did not improve overall survival. The results indicate the need for alternative therapies for cisplatin-ineligible patients.
WORLD JOURNAL OF UROLOGY
(2022)
Article
Oncology
Shu-peng Chen, Bao-xin Liu, Jie Xu, Xiao-feng Pei, Yi-ji Liao, Feng Yuan, Fang Zheng
Article
Oncology
Dong Qian, Kailin Chen, Haixia Deng, Huilan Rao, Huiqiang Huang, Yiji Liao, Xiaofei Sun, Suying Lu, Zhiyong Yuan, Dan Xie, Qingqing Cai
CLINICAL CANCER RESEARCH
(2015)
Article
Oncology
Lin-Lin Huang, Yi Zhang, Jia-Xing Zhang, Long-Jun He, Ying-Rong Lai, Yi-Ji Liao, Xiao-Peng Tian, Hai-Xia Deng, Ying-Jie Liang, Hsiang-Fu Kung, Dan Xie, Sen-Lin Zhu
Article
Gastroenterology & Hepatology
Long-Jun He, Dan Xie, Pin-Jin Hu, Yi-Ji Liao, Hai-Xia Deng, Hsiang-Fu Kung, Sen-Lin Zhu
WORLD JOURNAL OF GASTROENTEROLOGY
(2015)
Article
Multidisciplinary Sciences
Guo-Qing Wu, Xiao Wang, Hong-Ying Zhou, Ke-Qun Chai, Qian Xue, Ai-Hong Zheng, Xiu-Ming Zhu, Jian-Yong Xiao, Xu-Hua Ying, Fu-Wei Wang, Tao Rui, Li-Yun Xu, Yong-Kui Zhang, Yi-Ji Liao, Dan Xie, Li-Qin Lu, Dong-Sheng Huang
SCIENTIFIC REPORTS
(2015)
Article
Genetics & Heredity
Fang Zheng, Yi-Ji Liao, Mu-Yan Cai, Tian-Hao Liu, Shu-Peng Chen, Pei-Hong Wu, Long Wu, Xiu-Wu Bian, Xin-Yuan Guan, Yi-Xin Zeng, Yun-Fei Yuan, Hsiang-Fu Kung, Dan Xie
Article
Oncology
Chang-Peng Li, Mu-Yan Cai, Li-Juan Jiang, Shi-Juan Mai, Jie-Wei Chen, Feng-Wei Wang, Yi-Ji Liao, Wen-Hui Chen, Xiao-Han Jin, Xiao-Qing Pei, Xin-Yuan Guan, Mu-Sheng Zeng, Dan Xie
Article
Biochemistry & Molecular Biology
X-D Li, J-X Zhang, L-J Jiang, F-W Wang, L-L Liu, Y-J Liao, X-H Jin, W-H Chen, X. Chen, S-J Guo, F-J Zhou, Y-X Zeng, X-Y Guan, Z-W Liu, D. Xie
Article
Oncology
Tian-Hao Liu, Fang Zheng, Mu-Yan Cai, Lin Guo, Huan-Xin Lin, Jie-Wei Chen, Yi-Ji Liao, Hsiang-Fu Kung, Yi-Xin Zeng, Dan Xie
Article
Oncology
Guo-Qing Wu, Ke-Qun Chai, Xiu-Ming Zhu, Hua Jiang, Xiao Wang, Qian Xue, Ai-Hong Zheng, Hong-Ying Zhou, Yun Chen, Xiao-Chen Chen, Jian-Yong Xiao, Xu-Hua Ying, Fu-Wei Wang, Tao Rui, Yi-Ji Liao, Dan Xie, Li-Qin Lu, Dong-Sheng Huang
Article
Cell & Tissue Engineering
Hai-Yan Bai, Yi-Ji Liao, Mu-Yan Cai, Ning-Fang Ma, Qi Zhang, Jie-Wei Chen, Jia-Xing Zhang, Feng-Wei Wang, Chen-Yuan Wang, Wen-Hui Chen, Xiao-Han Jin, Rui-Hua Xu, Xin-Yuan Guan, Dan Xie
Article
Biochemistry & Molecular Biology
Wen-Hui Chen, Mu-Yan Cai, Jia-Xing Zhang, Feng-Wei Wang, Lin-Quan Tang, Yi-Ji Liao, Xiao-Han Jin, Chen-Yuan Wang, Ling Guo, Yi-Guo Jiang, Cai-Ping Ren, Hai-Qiang Mai, Mu-Sheng Zeng, Hsiang-Fu Kung, Chao-Nan Qian, Dan Xie
Review
Andrology
Yiji Liao, Kexin Xu
ASIAN JOURNAL OF ANDROLOGY
(2019)
Article
Oncology
Juyeong Hong, Ji Hoon Lee, Zhao Zhang, Yanming Wu, Mei Yang, Yiji Liao, Richard de la Rosa, Jessica Scheirer, Douglas Pechacek, Nu Zhang, Zhenming Xu, Tyler Curiel, Xi Tan, Tim H. -M. Huang, Kexin Xu
Summary: Inhibition of cancer-intrinsic EZH2 promotes antitumor immunity in breast cancer, requiring specific activation of type I IFN signaling. High levels of EZH2 and low levels of STAT2 in breast cancer patients are associated with the worst antitumor immune responses.
Article
Oncology
Yanming Wu, Zhao Zhang, Mauro E. Cenciarini, Cecilia J. Proietti, Matias Amasino, Tao Hong, Mei Yang, Yiji Liao, Huai-Chin Chiang, Virginia G. Kaklamani, Rinath Jeselsohn, Ratna K. Vadlamudi, Tim Hui-Ming Huang, Rong Li, Carmine De Angelis, Xiaoyong Fu, Patricia V. Elizalde, Rachel Schiff, Myles Brown, Kexin Xu