Article
Immunology
Rui Mao, Fan Yang, Tongtong Zhang, Ji Li
Summary: The incidence of cutaneous melanoma is rising, and better markers are needed to predict prognosis and immunotherapy effectiveness. By analyzing TCGA data and developing a signature based on immune checkpoint proteins, researchers were able to accurately predict prognosis and response to therapy in melanoma patients. The signature was found to be an independent prognostic factor and a nomogram based on the signature was more effective than the signature alone.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Oncology
James P. Pham, Anthony M. Joshua, Ines P. da Silva, Reinhard Dummer, Simone M. Goldinger
Summary: In the past decade, the management of metastatic cutaneous melanoma has been revolutionized with the development of highly effective therapies. However, the role of chemotherapy in melanoma treatment is still uncertain.
CURRENT ONCOLOGY REPORTS
(2023)
Article
Immunology
Mingjia Li, Xinrui Long, Wenbo Bu, Guanxiong Zhang, Guangtong Deng, Yuancheng Liu, Juan Su, Kai Huang
Summary: This study developed a novel prediction model of melanoma that takes into account individual differences in the tumor microenvironment. The immune-related risk score (IRRS), which considers the abundance of different immune cell types, showed good predictive capability for prognosis and immunotherapy effect in melanoma.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Yu Yang, Xuan Long, Guiyun Li, Xiaohong Yu, Yu Liu, Kun Li, Xiaobin Tian
Summary: This study successfully constructed an immune-related gene pair signature to predict the clinical prognosis of patients with cutaneous melanoma, revealing the significant role of immunity in the prognosis of CM and providing a new direction for personalized therapy.
Article
Immunology
Dan Liu, Xue Yang, Xiongzhi Wu
Summary: By analyzing immune infiltration patterns and related genes in melanoma, we constructed an ICI score to assess immune characteristics, revealing that patients with high ICI scores had better prognosis and enrichment in immune pathways, thus showing higher response rates to immunotherapy. This comprehensive immune infiltration landscape in melanoma provides insights for understanding the tumor microenvironment and developing new immune therapy strategies.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yi Zhao, Yanjun Wei, Lingjia Fan, Yuanliu Nie, Jianan Li, Renya Zeng, Jixian Li, Xiang Zhan, Lingli Lei, Zhichao Kang, Jiaxin Li, Wentao Zhang, Zhe Yang
Summary: In this study, a novel signature related to disulfidptosis was constructed, which accurately predicts the survival rate and treatment sensitivity of CM patients. Additionally, HLA-DQA1 is expected to be a feasible therapeutic target for effective clinical treatment of CM.
MOLECULAR MEDICINE
(2023)
Article
Immunology
Zheng Zhu, Guoyin Li, Zhenning Li, Yinghua Wu, Yan Yang, Mingyang Wang, Huihua Zhang, Hui Qu, Zewen Song, Yuanmin He
Summary: This study developed a novel risk score called core tumor-infiltrating immune cell score (cTICscore) to predict the prognosis of cutaneous melanoma (CM) patients. A new gene signature named cTILscore-related module gene score (cTMGs) was also identified, which showed a close correlation with cTICscore and could improve prognostic information. The findings suggest its potential as a predictive tool for CM patients receiving immunotherapy.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Genetics & Heredity
Congcong Xu, Hao Chen
Summary: The study developed a predictive model containing five ferroptosis-linked genes, with ALOX5 and GCH1 identified as independent predictive factors. Functional assessment revealed enriched immune-related cascades, and immune infiltrating analysis showed distinct immune microenvironments.
FRONTIERS IN GENETICS
(2021)
Article
Oncology
Zhong-Hao Ji, Wen-Zhi Ren, Shuo Yang, Dong-Xu Wang, Zi-Ping Jiang, Chao Lin, Ye Jin, Wen-Tai Tian
Summary: This study identified 6 MHC class II molecules (HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DRA, HLA-DRB1, HLA-DRB5) as important biomarkers in the occurrence and progression of SKCM tumors. Their expression levels are closely related to prognosis and immune infiltration.
AMERICAN JOURNAL OF CANCER RESEARCH
(2022)
Article
Biotechnology & Applied Microbiology
Xintao Cen, Mengna Li, Amin Yao, Yue Zheng, Wei Lai
Summary: This study aimed to establish a CAF-related signature for indicating prognosis and guiding therapeutic regimens of SKCM patients. A 10-gene CAF-related model was constructed, and the high-CAF risk group exhibited immunosuppressive features and worse prognosis. The CAF-related risk score could serve as a robust prognostic indicator and provide treatment strategies to improve outcomes in SKCM patients.
JOURNAL OF GENE MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Yi Zhou, Chen Wang, Yifang Chen, Wei Zhang, Zailin Fu, Jianbo Li, Jie Zheng, Minghua Xie
Summary: This study constructs a predictive risk model based on ARGs for accurate prediction of cutaneous melanoma (CM) patients, and provides potential guidance for personalized immune therapeutic strategies.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Wenna Guo, Xue Wang, Yanna Wang, Shuting Zhu, Rui Zhu, Liucun Zhu
Summary: This study established and validated a four-FRG DNA methylation signature that can independently predict the prognosis of cutaneous melanoma (CM) patients. This signature is strongly correlated with the immune landscape and may serve as a biomarker to guide clinicians in making more precise and personalized treatment decisions for CM patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Oncology
Dimitri Kasakovski, Marina Skrygan, Thilo Gambichler, Laura Susok
Summary: Cutaneous Melanoma (CM) is an aggressive cancer originating from pigment-producing melanocytes in the skin, with high metastatic potential. Although it represents a small fraction of skin cancers, it accounts for most skin-cancer-related deaths globally. Immune checkpoint inhibition has been a significant therapeutic approach, but challenges such as the immunosuppressive tumor microenvironment and treatment resistance persist. Combining local and systemic treatments can enhance therapeutic response and overcome resistance, yet complex drug combinations may increase the risk of immune-related adverse events.
Article
Cell Biology
Shuya Sun, Guanran Zhang, Litao Zhang
Summary: This study explored the prognostic and treatment value of ferroptosis-related lncRNAs in skin cutaneous melanoma (SKCM) and established a prognostic model based on 18 ferroptosis-related lncRNAs. The top three mutated ferroptosis genes in SKCM samples were TP53, ACSL5, and TF. Patients at low risk based on the model had better prognosis and higher immunophenoscore (IPS), indicating potential biomarkers and immunotherapy targets for SKCM.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Genetics & Heredity
Biao Huang, Wenxing Su, Daojiang Yu
Summary: This study investigates the immune infiltration and prognostic biomarkers in patients with BRAF mutated skin cutaneous melanoma. The results suggest that dysregulation of immune function and immune cells may contribute to poor outcomes in these patients.
FRONTIERS IN GENETICS
(2022)
Review
Medicine, General & Internal
Rafaela-Maria Kavasi, Monica Neagu, Carolina Constantin, Adriana Munteanu, Mihaela Surcel, Aristidis Tsatsakis, George N. Tzanakakis, Dragana Nikitovic
Summary: This article discusses the structural and functional modulations of the keratinocyte carcinoma microenvironment, focusing on the extracellular matrix (ECM) and its role in the pathogenesis of skin cancer.
FRONTIERS IN MEDICINE
(2022)
Editorial Material
Health Care Sciences & Services
Mircea Tampa, Monica Neagu, Constantin Caruntu, Simona Roxana Georgescu
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Health Care Sciences & Services
Simona Roxana Georgescu, Andreea Amuzescu, Cristina Iulia Mitran, Madalina Irina Mitran, Clara Matei, Carolina Constantin, Mircea Tampa, Monica Neagu
Summary: Platelet-rich plasma (PRP) therapy is a novel treatment that has been extensively tested and is increasingly used in dermatology and cosmetic surgery. It has shown significant effectiveness in treating androgenic alopecia (AGA).
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Editorial Material
Chemistry, Multidisciplinary
Giuseppe Bardi, Monica Neagu
Review
Health Care Sciences & Services
Elena-Georgiana Dobre, Carolina Constantin, Monica Neagu
Summary: Skin cancer, including basal cell carcinoma, squamous cell carcinoma, and cutaneous melanoma, poses important challenges for the healthcare system worldwide. Recent studies have shown that ddPCR is a powerful technology for skin cancer analysis, capable of discovering and validating biomarkers for personalized treatment monitoring.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Elena-Georgiana Dobre, Mihaela Surcel, Carolina Constantin, Mihaela Adriana Ilie, Ana Caruntu, Constantin Caruntu, Monica Neagu
Summary: Early diagnosis is crucial for effectively treating skin cancer. Emerging optical imaging techniques, such as RCM, OCT, MRI, NIR bioimaging, and PET, can provide non-invasive imaging data for early detection and monitoring of cutaneous tumors. These techniques can observe dynamic processes relevant to disease evolution, including blood flow, immune cell activation, and tumor energy metabolism. This review discusses the latest advances in imaging techniques for skin cancer detection and monitoring, highlighting the challenges and opportunities for their implementation in clinical practice and their potential to complement molecular and histological approaches.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Aikaterini Berdiaki, Monica Neagu, Ioanna Spyridaki, Andrey Kuskov, Serge Perez, Dragana Nikitovic
Summary: Hyaluronan (HA) is a natural compound that is found on the cell surface and tissue extracellular matrix. It is synthesized by enzymes and degraded by other substances. HA has different effects on the body depending on its molecular weight, with high molecular weight HA being anti-inflammatory and low molecular weight HA being pro-inflammatory. Reactive oxygen species (ROS) can degrade HA and affect vascular integrity, while HA can also play a role in wound healing. Understanding the interactions between ROS and HA is an important research topic.
Review
Nutrition & Dietetics
Carolina Constantin, Mihaela Surcel, Adriana Munteanu, Monica Neagu, Jean Christopher Chamcheu
Summary: Psoriasis, an autoimmune chronic inflammatory skin condition, is influenced by genetic factors, immune disturbances, and environmental factors, especially the Western lifestyle and overall diet. Obesity is identified as a significant risk factor for psoriasis, aggravating the disease, while weight reduction can improve clinical outcomes. The connection between obesity and psoriasis lies in the pro-inflammatory effects of white adipose tissue, which is an important endocrine organ. This paper emphasizes the importance of nutrition strategies in psoriasis management.
Article
Health Care Sciences & Services
Mihaela Surcel, Carolina Constantin, Adriana Narcisa Munteanu, Diana Antonia Costea, Gheorghita Isvoranu, Elena Codrici, Ionela Daniela Popescu, Cristiana Tanase, Alef Ibram, Monica Neagu
Summary: This study investigated the effect of purified IgY treatment on psoriatic dermatitis using a murine model. The results showed that orally purified IgY treatment can improve skin lesion healing and normalize cellular and humoral immune parameters.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Review
Polymer Science
Antonella Caterina Boccia, Alfio Pulvirenti, Carlos A. Garcia-Gonzalez, Fabia Grisi, Monica Neagu
Summary: Aerogels, as nanostructured highly porous materials, are increasingly used in various industries with different applications. However, due to the lack of data availability, ensuring the safe development and use of aerogel-based products poses challenges. The safety regulatory Compendium aims to share knowledge and best safety practices with the international aerogels community and stakeholders.
Article
Health Care Sciences & Services
Ana Caruntu, Liliana Moraru, Mihaela Surcel, Adriana Munteanu, Daniel Octavian Costache, Cristiana Tanase, Carolina Constantin, Cristian Scheau, Monica Neagu, Constantin Caruntu
Summary: This study assessed the proportions of different lymphocyte subsets in the peripheral blood of oral squamous cell carcinoma (OSCC) patients and found immune changes associated with the development of OSCC, providing new insights into the complex connections between immuno-inflammatory processes and carcinogenesis.