Journal
BIOMED RESEARCH INTERNATIONAL
Volume 2013, Issue -, Pages -Publisher
HINDAWI LTD
DOI: 10.1155/2013/394523
Keywords
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Funding
- CONACYT SALUD [2005-C02-14412]
- Proyectos Estrategicos [IMSS-2004/014, 2005/2/I/363, 2006/1B/1/002]
- Fundacion IMSS A.C
- Fundacion Gonzalo Rio Arronte I. A. P. Mexico
- Vinculacion del Cinvestav con el Sector Salud Support Program
- Fundacion IMSS Scholarship, Mexico
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Objective. We aimed to explore the association between polymorphisms of IRS1 (rs1801278), TCF7L2 (rs7903146 and rs12255372), ADRB1 (rs1801253), PPARG (rs1801282), and HHEX (rs5015480) genes with atherogenic risk (AI = Total cholesterol/HDL) inMetS, T2D, and healthy populations from theMexican Social Security Institute. Methodology and Results. Four hundred thirty-fiveMetS, 517 T2D, and 547 healthy individuals were selected. The association between the SNPs and the atherogenic index was evaluated by multiple linear regression andmultinomial logistic regressionmodels. TheADRB1 gene showed a statistically significant association with high-risk atherogenic index, OR = 2.94 (IC 95% 1.64-5.24; P< 0.0001) for the Arg/Gly variant, under the dominant model an OR = 2.96 (IC 95% 1.67-5.25; P< 0.0001), and under the Log additive model an OR = 2.52 (IC 95% 1.54-4.15; P< 0.0001). Conclusions. The Arg389Gly polymorphismof the ADRB1 gene may be a worthy biological marker to predict the risk of developing cardiovascular diseases given a high-risk atherogenic index.
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