Catalytic Enantioselective α-Chlorination of Carbonyl Compounds

Access to Both Enantiomers of α-Chloro-β-keto Esters with a Single Chiral Ligand: Highly Efficient Enantioselective Chlorination of Cyclic β-Keto Esters Catalyzed by Chiral Copper(II) and Zinc(II) Complexes of a Spiro-2,2′-bischroman-Based Bisoxazoline Li

(2012) Jie Li et al.   ADVANCED SYNTHESIS & CATALYSIS

Substrate Range of the Titanium TADDOLate Catalyzed Asymmetric Fluorination of Activated Carbonyl Compounds

(2012) Andreas Bertogg et al.   HELVETICA CHIMICA ACTA

Highly Enantioselective Chlorination of β-Keto Esters and Subsequent SN2 Displacement of Tertiary Chlorides: A Flexible Method for the Construction of Quaternary Stereogenic Centers

(2012) Kazutaka Shibatomi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A General, Enantioselective Synthesis of Protected Morpholines and Piperazines

(2012) Matthew C. O’Reilly et al.   ORGANIC LETTERS

Catalytic enantioselective chlorination of cyclic β-keto esters in the presence of chiral Pd(II) complexes

(2012) Young Ku Kang et al.   TETRAHEDRON LETTERS

Cyclopropyl Iminium Activation: Reactivity Umpolung in Enantioselective Organocatalytic Reaction Design

(2011) Christof Sparr et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Access to High Levels of Molecular Complexity by One-Pot Iridium/Enamine Asymmetric Catalysis

(2011) Adrien Quintard et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Development of the titanium–TADDOLate-catalyzed asymmetric fluorination of β-ketoesters

(2011) Lukas Hintermann et al.   Beilstein Journal of Organic Chemistry

Transforming terpene-derived aldehydes into 1,2-epoxides via asymmetric α-chlorination: subsequent epoxide opening with carbon nucleophiles

(2011) Philipp Winter et al.   CHEMICAL COMMUNICATIONS

Cinchona Alkaloid Catalyzed Enantioselective Chlorination of 3-Aryloxindoles

(2011) Mei-Xin Zhao et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Catalytic Asymmetric α-Chlorination of 3-Acyloxazolidin-2-one with a Trinary Catalytic System

(2011) Yoshitaka Hamashima et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Chiral Calcium VAPOL Phosphate Mediated Asymmetric Chlorination and Michael Reactions of 3-Substituted Oxindoles

(2011) Wenhua Zheng et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Enantioselectivegem-Chlorofluorination of Active Methylene Compounds Using a Chiral Spiro Oxazoline Ligand

(2011) Kazutaka Shibatomi et al.   ORGANIC LETTERS

Enantioselective synthesis of C2-functionalized, N-protected morpholines and orthogonally N,N′-protected piperazines via organocatalysis

(2011) Matthew C. O’Reilly et al.   TETRAHEDRON LETTERS

Axially chiral BINIM and Ni(II)-catalyzed asymmetric chlorination of 3-substituted oxindoles

(2011) De Wang et al.   TETRAHEDRON-ASYMMETRY

Enantioselective organocatalytic α-heterofunctionalization of active methines

(2011) Alessio Russo et al.   RSC Advances

Chiral Amino Diol Derivatives as New Modular Organocatalysts for the Enantioselective α-Chlorination of Cyclic β-Keto Esters

(2010) Pablo Etayo et al.   ADVANCED SYNTHESIS & CATALYSIS

Highly Enantioselective One-Pot Copper-Catalyzed 1,4 Addition/Organocatalyzed α-Substitution of Enals

(2010) Adrien Quintard et al.   ADVANCED SYNTHESIS & CATALYSIS

Catalytic Enantioselective Fluorination of α-Chloro-β-keto Esters in the Presence of Chiral Nickel Complexes

(2010) Seung Hee Kang et al.   ADVANCED SYNTHESIS & CATALYSIS

Highly enantioselective α-chlorination of cyclic β-ketoesters catalyzed by N,N′-Dioxide using NCS as the chlorine source

(2010) Yunfei Cai et al.   CHEMICAL COMMUNICATIONS

Transition Metal Catalyzed Enantioselective α-Heterofunctionalization of Carbonyl Compounds

(2010) Alexander M. R. Smith et al.   CHEMICAL REVIEWS

Enantioselective α-Fluorination and Chlorination of β-Ketoesters by Cobalt Catalyst

(2010) Motoi Kawatsura et al.   CHEMISTRY LETTERS

Cu(I)-catalyzed asymmetric chlorination of β-keto esters in the presence of chiral phosphine-schiff base type ligands

(2010) Jia-Jun Jiang et al.   CHIRALITY

NHC-Mediated Chlorination of Unsymmetrical Ketenes: Catalysis and Asymmetry

(2010) James Douglas et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

General Access to ChiralN-Alkyl Terminal Aziridines via Organocatalysis

(2010) Olugbeminiyi O. Fadeyi et al.   ORGANIC LETTERS

Regioselective and Stereoselective Cyclizations of Chloropolyols in Water: Rapid Synthesis of Hydroxytetrahydrofurans

(2010) Baldip Kang et al.   ORGANIC LETTERS

Alternative Synthetic Strategies for Enantioselective Construction of Halogenated Chiral Carbon Centers

(2010) Kazutaka Shibatomi   SYNTHESIS-STUTTGART

Synthesis of novel chiral oxazoline-Schiff base ligands for the catalytic asymmetric chlorination of β-keto esters

(2010) Ming-Hui Qi et al.   TETRAHEDRON-ASYMMETRY

Enantioselective Linchpin Catalysis by SOMO Catalysis: An Approach to the Asymmetric α-Chlorination of Aldehydes and Terminal Epoxide Formation

(2009) Muriel Amatore et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A DBFOX-Ph-Based Combinatorial Catalyst for Enantioselective Fluorination of Aryl Acetyl and 3-Butenoyl Thiazolidinones

(2009) Dhande Sudhakar Reddy et al.   Chemistry-An Asian Journal

Enantioselective Halogenation of β-Oxo Esters Catalyzed by a Chiral Sulfoximine-Copper Complex

(2009) Marcus Frings et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Organocatalyzed direct asymmetric α-halogenation of carbonyl compounds

(2009) Mitsuhiro Ueda et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Development of a New Chiral Spiro Oxazolinylpyridine Ligand (Spymox) for Asymmetric Catalysis

(2009) Kazutaka Shibatomi et al.   SYNLETT

Stereoselective Synthesis of α,α‐Chlorofluoro Carbonyl Compounds Leading to the Construction of Fluorinated Chiral Quaternary Carbon Centers

(2008) Kazutaka Shibatomi et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Lewis Acid-catalyzed Asymmetric Fluorinations of β-Keto Esters: Dramatic Improvement in Enantioselectivity by Changing the Operation Sequence

(2008) Kazutaka Shibatomi et al.   CHEMISTRY LETTERS