Article
Chemistry, Organic
Tongyan Yu, Fei Ji, Daichuan Huang, Ya Gao, Zhaoping Shi, Xuan Sha, Jiangyan Xu, Siliang You, Mingzhi Zhang, Qiang Sha
Summary: The article presents a novel method for synthesizing highly functionalized pyrrole compounds, with the key to success lying in the precise capture of the carbocation intermediate by utilizing enaminones and anilines, allowing the amination reaction to proceed smoothly at specific positions.
ORGANIC CHEMISTRY FRONTIERS
(2021)
Article
Chemistry, Organic
Michael Hoffelner, Werner Seebacher, Usama Hassan, Andreas Leitner, Robert Weis, Robert Saf
Summary: This new reduction process efficiently prepares various piperidin-4-one derivatives, especially 2-substituted ones, which were previously inaccessible by other reaction pathways. The starting materials are tetrahydropyridinylidene salts, which can be synthesized through two different reaction sequences and modified with various substituents before obtaining the target piperidin-4-ones.
Article
Engineering, Environmental
Siti Nor Farhana Zakaria, Hamidi Abdul Aziz, Motasem Y. D. Alazaiza
Summary: This study investigates the efficiency of ozone combined with zirconium tetrachloride or tin tetrachloride in remediating landfill leachate. The results show that the O3/ZrCl4 combination significantly enhances the oxidation process and pollutant removal, as well as improves the biodegradability of the leachate.
WATER ENVIRONMENT RESEARCH
(2022)
Article
Chemistry, Organic
Yoarhy A. Amador-Sanchez, Pedro Lopez-Mendoza, Marco Mijangos, Luis D. Miranda
Summary: This synthesis protocol efficiently produces poly-functionalized compounds through a series of reactions.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Muralikrishna Yaragani, Prasad Yadlapalli, Sriram Raghavan, Giridhar Thota, Venkata Basaveswara Rao Mandava, Ravindra Vikram Singh, Rajasekhara Prasad Kottapalli, Chinnusamy Saravanan
Summary: Androgen deprivation therapy is a first-line treatment option for prostate cancer patients, but may lead to the development of castration-resistant prostate cancer. Enzalutamide has been approved by the US FDA for the treatment of CRPC, and more recently for nmCRPC. Research has discovered new pharmacophore structures as potential next generation AR antagonists.
Article
Chemistry, Multidisciplinary
Andrey D. Vinokurov, Taygib M. Iliyasov, Kirill A. Karpenko, Alexandra V. Evstigneeva, Alexandra P. Minaeva, Michail N. Elinson, Anatoly N. Vereshchagin
Summary: The Michael-Mannich-cyclization cascade reaction of four compounds leads to the stereoselective formation of halogenides with three stereogenic centers. Ammonium acetate acts as both a base and a nitrogen source.
MENDELEEV COMMUNICATIONS
(2023)
Article
Multidisciplinary Sciences
Hadis Goudarzi, Davood Habibi, Arezo Monem
Summary: A novel deep eutectic solvent (ETPP-Br/THF-TCA-DES) was prepared and used as a catalyst for the synthesis of two sets of compounds, with short reaction time, high yields, and easy recycling of the catalyst. Characterization tests confirmed the consistency between the proposed structure of the solvent and the NMR results, providing evidence of hydrogen bond formation.
SCIENTIFIC REPORTS
(2023)
Article
Chemistry, Multidisciplinary
Yu-Han Lu, Si-Yu Mu, Jun Jiang, Min-Hang Zhou, Chao Wu, Hong-Tao Ji, Wei-Min He
Summary: A green and practical method for the electrochemical synthesis of tetrahydroimidazo[1,5-a]quinoxalin-4(5H)-ones through the three-component reaction of quinoxalin-2(1H)-ones, N-arylglycines and paraformaldehyde was reported. In this strategy, EtOH played dual roles (eco-friendly solvent and waste-free pre-catalyst) and the in situ generated ethoxide promoted triple sequential deprotonations.
Article
Chemistry, Organic
Juan F. Ortuno, Samet Poyraz, Asmaa Belabbes, Ozge Kavas, Samet Belveren, Cevher Altug, Maria de Gracia Retamosa, Francisco Foubelo, Christopher M. Pask, Jose M. Sansano, H. Ali Dondas
Summary: A new and mild methodology using benign solvents is reported for the synthesis of 4-arylthiazol-2(3H)-ones. Additionally, the multicomponent preparation of 5,5'-methylenebis[4-arylthiazol-2(3H)-ones] is described using the same strategy. The mechanism is analyzed and confirmed through chemical tests.
SYNTHESIS-STUTTGART
(2023)
Article
Engineering, Environmental
Siti Nor Farhana Zakaria, Hamidi Abdul Aziz, Maheera Mohamad, Habib Musa Mohamad, Mohd Fauzy Sulaiman
Summary: The performance of ozonation with ZrCl4 and SnCl4 for remediation of stabilized landfill leachate was examined and optimized using response surface methodology. The results showed that ozonation with ZrCl4 achieved better pollutant removal compared to ozonation with SnCl4. At the optimum conditions, both methods achieved removal of 89% to 99.8% of pollutants in the leachate, producing clear effluent.
WATER ENVIRONMENT RESEARCH
(2023)
Article
Chemistry, Multidisciplinary
V Manjula, R. Venkateswaramoorthi, J. Dharmaraja, S. Bharanidharan
Summary: A series of 3-allyl-2,6-diarylpiperidin-4-one derivatives were synthesized as antimicrobial agents and characterized. The compounds showed good antibacterial and antifungal activities. Molecular docking study indicated their potential as drugs.
Article
Chemistry, Applied
Julien Annibaletto, Thomas Martzel, Vincent Levacher, Sylvain Oudeyer, Jean-Francois Briere
Summary: The strategy reported involves a multicomponent catalytic enantioselective synthesis of beta-substituted isoxazolidin-5-ones via a KMC process promoted by a suitable bifunctional organocatalyst. The hydroxamic acid component with sterically hindered amide moiety is crucial for the successful formation and transformation of the N-amide isoxazolidin-5-ones obtained.
ADVANCED SYNTHESIS & CATALYSIS
(2021)
Article
Chemistry, Organic
Amr Elagamy, Ranjay Shaw, Chandan Shah, Ramendra Pratap
Summary: An efficient iodine-mediated method has been developed for the synthesis of functionalized 2-(methylthio)-4H-chromen-4-ones, which serve as key precursors for various chemical reactions. Mechanistically, the intramolecular cyclization of ketene dithioacetal was observed to proceed through a radical pathway. 3-Halo-2-(methylthio)-4H-chromen-4-ones were obtained via various two- or one-pot halogenation approaches.
JOURNAL OF ORGANIC CHEMISTRY
(2021)
Article
Chemistry, Organic
Ajeet A. Yelwande, Madhukar E. Navgire, Manoj Palve, Harshal S. Patil, Mazahar Farooqui, Jaysing M. Dinore
Summary: This study presents a green synthesis method for the one-pot five-component synthesis of tetrahydropyridines using a polyaniline-zirconium oxide catalyst. The catalyst exhibits excellent catalytic activity and can be easily recovered and reused up to seven cycles. The method offers significant advantages in terms of simplicity, affordability, and wide substrate scope.
SYNTHETIC COMMUNICATIONS
(2022)
Article
Chemistry, Physical
Prabhakara Madivalappa Davanagere, Mrinmoy De, Kaushik Chanda, Barnali Maiti
Summary: An efficient and novel bifunctional ionic liquid-supported (S)-proline organocatalyst was developed for the synthesis of highly functionalized tetrahydropyridines. The reaction involved five components and allowed for the simultaneous generation of five bonds and two stereogenic centers with excellent diastereo- and enantioselectivities. The catalyst could be recycled five times without significant loss of activity.
