Article
Pharmacology & Pharmacy
Sonia Gera, Sunitha Sampathi, Sravya Maddukuri, Sujatha Dodoala, Vijayabhaskarreddy Junnuthula, Sathish Dyawanapelly
Summary: Naringenin nanosuspension (NRG-NS) demonstrated anti-osteoporotic activity by upregulating osteocalcin levels in MG-63 cells and normalized bone density and biochemical parameters in an osteoporotic rat model. The results suggest that oral administration of NRG-NS could be a potential therapeutic formulation for osteoporosis treatment.
Article
Pharmacology & Pharmacy
Mohammed Elmowafy, Khaled Shalaby, Mohammad M. Al-Sanea, Omnia M. Hendawy, Ayman Salama, Mohamed F. Ibrahim, Mohammed M. Ghoneim
Summary: This study prepared a luteolin-loaded nanosuspension and compared the effects of four stabilizers, finding that nanosuspensions stabilized by alginate showed the smallest particle size and the highest zeta potential value. Alginate increased stability through dual stabilizing effects, while Pluronic F127 improved skin delivery and pharmacodynamic efficacy.
Article
Chemistry, Multidisciplinary
M. C. C. Peters, I. F. de Oliveira, M. G. M. Machado, D. C. Ferreira, M. H. A. Zanin, N. Bou-Chacra
Summary: An innovative ophthalmic anti-inflammatory nanosuspension was developed using a design space approach, reducing the particle size of a glucocorticoid derivative to approximately 165.0 nm through wet bead milling. Experimental design supported formula optimization and determined the design space, proposing an optimized formulation for potential ophthalmic use.
MATERIALS TODAY CHEMISTRY
(2021)
Article
Pharmacology & Pharmacy
Paramita Saha, Himanshu Kathuria, Murali Monohar Pandey
Summary: This study developed a poloxamer-stabilized RTG-Nanosuspension for intranasal administration, which showed potential in nose-to-brain delivery for targeted application in Parkinson's disease.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Medicine, General & Internal
Mohsen Hedaya, Farzana Bandarkar, Aly Nada
Summary: The study prepared IBU/PP/TW nanosuspensions, which exhibited excellent in vitro and in vivo performance with significantly reduced particle size, enhanced dissolution rate, and higher bioavailability compared to other formulations.
MEDICAL PRINCIPLES AND PRACTICE
(2021)
Article
Pharmacology & Pharmacy
Sicheng Yao, Naiying Chen, Xinxing Sun, Qiuyue Wang, Mingming Li, Yang Chen
Summary: This study investigates the effect of particle size on the skin penetration ability of andrographolide nanosuspensions. It is found that smaller particle size enhances drug retention in the skin and promotes drug permeation. Laser scanning confocal microscopy and histopathological analysis demonstrate that the nanosuspensions can deliver the drug into the intercellular lipid space and block the hair follicle in the skin.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Chemistry, Applied
Alptug Karakucuk, Serdar Tort, Sevtap Han, Ayse Nur Oktay, Nevin Celebi
Summary: The study aimed to develop a dermal nanosuspension-based gel formulation of etodolac (ETD), with ETD-NS achieving a particle size of approximately 190 nm, PDI of 0.16, and ZP values of -15 mV. The dermal permeation of ETD from NS-HEC gel was significantly higher than NS-HPMC gel, and NS-HEC gel showed enhanced anti-inflammatory and analgesic activity compared to micronised ETD.
JOURNAL OF MICROENCAPSULATION
(2021)
Article
Multidisciplinary Sciences
Smita Kakad, Sanjay Kshirsagar
Summary: The study successfully prepared Efavirenz nanosuspension for nose to brain drug transport to bypass the blood brain barrier, targeting viral reservoirs in the brain. In vivo studies showed direct nose to brain transport of Efavirenz nanoparticle, suggesting it as a potential alternative for neuro-AIDS treatment.
Article
Pharmacology & Pharmacy
Gongsen Chen, Yuling Liu, Guolin Shi, Yuting Luo, Sai Fu, Anhui Yang, Yingying Zhou, Yanqiu Wu, Longfei Lin, Hui Li
Summary: In this study, a near-infrared photothermal Celastrol nanosuspension was successfully prepared, which exhibited high dissolution and sustained release in vitro and showed potent antitumor efficacy in cell experiments.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Chemistry, Medicinal
Yuosef Al Ayoub, Asma Buzgeia, Ghadeer Almousawi, Hassan Raza Ali Mazhar, B. Alzouebi, Rajendran C. Gopalan, K. H. Assi
Summary: In vitro dissolution testing is essential in the pharmaceutical industry, and a method for investigating the dissolution profile of inhaled products has been developed. The study modified the Twin Stage Impinger to examine the in vitro-in vivo correlation and enhance the Fine Particle Dose collection method for dry powder inhalers. The results showed that the modified Twin Impinger effectively tested the dissolution rate of drugs. Comparison with actual in vivo pharmacokinetic values validated the effectiveness of this in vitro dissolution method.
JOURNAL OF PHARMACEUTICAL SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Mayank Singhal, Elina Turunen, Tuula Ahtola-Satila, John Aspegren, J. Raymond Bratty, Rainard Fuhr, Krista Ojala, Bert van Veen, Leena Peltonen
Summary: Reducing particle size increases drug dissolution rate and enhances the bioavailability of poorly soluble compounds. However, for the practically insoluble investigational drug ODM-106, nanoformulations showed unexpectedly low bioavailability for the highest capsule strength compared to a lower strength in clinical study. Further investigation revealed that the concentration of stabilizers significantly influenced the degree of supersaturation, and the drug load, nanoparticle/polymer ratio, and drying step were critical to the performance of the nanoformulations.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2022)
Article
Pharmacology & Pharmacy
Ahmed Hassen Elshafeey, Rania Moataz El-Dahmy
Summary: The study aimed to develop and optimize palatable oral fast-dissolving films (OFDFs) loaded with a paroxetine nanosuspension to increase the bioavailability of paroxetine. OFDFs offer convenience for patients with mental illness and are suitable for pediatric, elderly, and developmentally disabled patients.
Article
Pharmacology & Pharmacy
Changzhi Shi, Jelisaveta Ignjatovic, Tingting Liu, Meihua Han, Dongmei Cun, Jelena Duris, Mingshi Yang, Sandra Cvijic
Summary: This study investigated the absorption patterns of three different inhaled formulations using in silico modeling with budesonide as a model drug. The study revealed that factors such as pulmonary solubility and absorption rate constant were key in influencing pulmonary absorption of different formulations, while significant gastrointestinal absorption was observed with commercially available micronized budesonide. The in vitro-in vivo-in silico approach used in this study may help facilitate the development of orally inhaled formulations with different drug release/absorption rates.
ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2021)
Article
Chemistry, Physical
Sujit Bose, Pooja Sharma, Vijay Mishra, Swati Patial, Gaurav K. Saraogi, Murtaza M. Tambuwala, Kamal Dua
Summary: Different methods were used to prepare GLM loaded nanosuspension in this study, showing that nanosuspension prepared by combination technique has better solubility and dissolution than those prepared by nanoprecipitation technique.
JOURNAL OF MOLECULAR STRUCTURE
(2021)
Article
Pharmacology & Pharmacy
Hetal P. Patel, Priyanka S. Chaudhari, Priyanshi A. Gandhi, Bhargavi Desai, Ditixa T. Desai, Praful P. Dedhiya, Bhavin A. Vyas, Furqan A. Maulvi
Summary: Clozapine nanosuspension prepared for intranasal delivery showed improved drug permeability and increased therapeutic concentration in brain tissue compared to conventional oral clozapine suspension, suggesting its potential for successful nose-to-brain drug delivery.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Pharmacology & Pharmacy
Abdel-Azim Zaghloul, Ahmad Lila, Fathy Abd-Allah, Aly Nada
JOURNAL OF DRUG TARGETING
(2017)
Article
Chemistry, Multidisciplinary
Hamdy Abdelkader, Zeinab Fathalla
PHARMACEUTICAL RESEARCH
(2018)
Review
Pharmacology & Pharmacy
Ameeduzzafar, Javed Ali, Mohd Fazil, Mohd Qumbar, Nazia Khan, Asgar Ali
Article
Pharmacology & Pharmacy
Zhonglan Wang, Zhongwen Li, Dong Zhang, Lei Miao, Guihua Huang
Review
Nanoscience & Nanotechnology
Maria Joao Gomes, Jose das Neves, Bruno Sarmento
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2014)
Article
Nanoscience & Nanotechnology
Shu-min Ding, Zhen-hai Zhang, Jie Song, Xu-dong Cheng, Jun Jiang, Xiao-bin Jia
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2014)
Article
Pharmacology & Pharmacy
Abdelazim Zaghloul, Ahmed Lila, Fathy Abd-Allah, Aly Nada
CURRENT DRUG DELIVERY
(2019)
Article
Chemistry, Medicinal
Rehab Abdelmonem, Marian Sobhy Azer, Amna Makky, Abdelazim Zaghloul, Mohamed El-Nabarawi, Aly Nada
DRUG DESIGN DEVELOPMENT AND THERAPY
(2020)
Article
Medicine, General & Internal
Mohsen Hedaya, Farzana Bandarkar, Aly Nada
Summary: The study prepared IBU/PP/TW nanosuspensions, which exhibited excellent in vitro and in vivo performance with significantly reduced particle size, enhanced dissolution rate, and higher bioavailability compared to other formulations.
MEDICAL PRINCIPLES AND PRACTICE
(2021)
Article
Pharmacology & Pharmacy
Farzana Bandarkar, Willias Masocha, Aly Nada
Summary: The optimized ibuprofen nanoformulation showed improved dissolution and pharmacodynamic properties compared to other formulations. There was a good correlation between paw oedema inhibition and peak serum concentration (C-max) as well as time at which the C-max is observed (T-max). Additionally, a good correlation was observed between inhibition of formalin-induced nociception and AUC and C-max, but not T-max.
JOURNAL OF PHARMACY AND PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Reham Al-Kazemi, Yaqoub Al-Basarah, Aly Nada
ASIAN JOURNAL OF PHARMACEUTICS
(2020)
Article
Pharmacology & Pharmacy
Reham Al-Kazemi, Yacoub Al-Basarah, Aly Nada
ADVANCED PHARMACEUTICAL BULLETIN
(2019)
Article
Pharmacology & Pharmacy
Aly Nada, Abdel-Azim Zaghloul, Monerah Al-Soraj, Yaqoub Al-Basarah
ASIAN JOURNAL OF PHARMACEUTICS
(2018)
Article
Pharmacology & Pharmacy
Aly Nada, Farzana Bandarkar, Yaqoub Al-Basarah
ASIAN JOURNAL OF PHARMACEUTICS
(2017)