Article
Chemistry, Applied
Shikha Kumari, Pradeep Srivastava, Abha Mishra
Summary: In this study, chitosan and gelatin-based artificial biomimetic 3D structures were developed and loaded with nanobioglass and beta tri-calcium phosphate to create potential artificial acellular bone grafts. The scaffolds exhibited porous structure, low swelling, and high mechanical properties, while promoting cell viability and osteogenesis.
JOURNAL OF POROUS MATERIALS
(2023)
Article
Materials Science, Ceramics
C. Ruiz-Aguilar, U. Olivares-Pinto, I Alfonso
Summary: In this study, six different compositions of β-TCP scaffolds were produced using sodium chloride as a porogen at varying concentrations. The scaffolds showed promising physical, chemical, mechanical, and in vitro properties, with the formation of new crystalline phases and favorable bioactivity observed.
CERAMICS INTERNATIONAL
(2021)
Article
Biophysics
Jian He, Zhidong Lin, Xulin Hu, Luyao Xing, Gaofeng Lian, Dongliang Chen, Junling An, Chengdong Xiong, Xiangchun Zhang, Lifang Zhang
Summary: The study developed bioactive scaffolds with favorable mechanical properties and osteogenesis promotion, which could be a promising alternative to bone cement in bone tissue engineering.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Article
Engineering, Biomedical
Xulin Hu, Hu Li, Liang Qiao, Shuhao Yang, Haoming Wu, Chao Peng, Yamei Zhang, Hai Lan, Hua Yang, Kainan Li
Summary: Human bones consist of cortical and cancellous bone, with cancellous bone being porous and cortical bone being dense. Porous ceramics are a promising area of research in bone tissue engineering due to their similarity to human bone. 3D printing of ceramics is a popular method for fabricating porous scaffolds that meet the requirements of cancellous bone strength and complex shapes. In this study, beta-tricalcium phosphate (beta-TCP)/titanium dioxide (TiO2) porous ceramics scaffolds were successfully fabricated using 3D gel-printing sintering, with a uniform porous structure and enhanced compressive strength. The scaffolds showed no toxicity and exhibited excellent cell adhesion and proliferation, making them a potential candidate for orthopedic and traumatology repair scaffolds.
INTERNATIONAL JOURNAL OF BIOPRINTING
(2023)
Article
Materials Science, Ceramics
Patricia Ros-Tarraga, Carlos M. Martinez, Miguel A. Rodriguez, Piedad N. De Aza
Summary: The elderly population is increasing, leading to an increase in bone and joint problems. Scaffold for bone tissue regeneration can solve these problems, and material selection is crucial for satisfactory results. This study designed a three-dimensional porous ceramic scaffold and analyzed its biocompatibility and osteoinductive capacity. The results suggest that it has potential applications as bone substitutes.
CERAMICS INTERNATIONAL
(2022)
Article
Materials Science, Multidisciplinary
C. Ruiz-Aguilar, L. Gaytan-Tocaven, R. G. Paredes
Summary: Beta-TCP is a promising bioceramic with similar composition to bones and teeth, which stimulates the formation of bone tissue. It can be used in various ways in the human body, mainly for the regeneration and stimulation of cortical and trabecular bone tissue. In a skull implant experiment on rats, the beta-TCP scaffold showed excellent bioactivity, stimulating new bone formation without affecting the animals' motor and cognitive abilities.
MATERIALS CHEMISTRY AND PHYSICS
(2022)
Article
Biochemistry & Molecular Biology
Xiangling Ye, Yongqiang Zhang, Tao Liu, Zehua Chen, Weijian Chen, Zugui Wu, Yi Wang, Junyi Li, Congcong Li, Tao Jiang, Ying Zhang, Huai Wu, Xuemeng Xu
Summary: In this study, 3D-printed PHA/β-TCP scaffolds were successfully prepared by adding beta-TCP to PHA and using a twin-screw extruder and fused deposition modeling technique. The scaffolds exhibited good mechanical properties and biocompatibility, and promoted cell proliferation, adhesion, and migration, as well as enhanced osteogenesis-related gene expression.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Materials Science, Ceramics
Mahdieh Hajian Monfared, Faezeh Esmaeili Ranjbar, Maryam Torbati, S. Ali Poursamar, Nasrin Lotfibakhshaiesh, Jafar Ai, Somayeh Ebrahimi-Barough, Mahmoud Azami
Summary: In this research, a three-dimensional 45S5 bioactive glass (BG)/beta-tricalcium phosphate (TCP) composite scaffold with controlled and interconnected porosity and notable mechanical strength was successfully prepared by the Robocasting method. The scaffold exhibited good bioactivity and supported the attachment and proliferation of mesenchymal stem cells, with limited effect on cell survival.
JOURNAL OF NON-CRYSTALLINE SOLIDS
(2022)
Article
Chemistry, Physical
Kuo-Sheng Hung, May-Show Chen, Wen-Chien Lan, Yung-Chieh Cho, Takashi Saito, Bai-Hung Huang, Hsin-Yu Tsai, Chia-Chien Hsieh, Keng-Liang Ou, Hung-Yang Lin
Summary: In this study, a 3D printed porous scaffold composed of β-TCP and F-127 was proposed for bone defect treatment. The scaffold demonstrated well-defined porosity, excellent microstructural interconnectivity, and acceptable wettability. It also exhibited good cell viability and attachment behavior. The scaffold with a pore size of around 350 μm showed the highest bone formation volume and can provide proper loading support for bone regeneration.
Article
Biochemistry & Molecular Biology
Akbar Teguh Prakoso, Hasan Basri, Dendy Adanta, Irsyadi Yani, Muhammad Imam Ammarullah, Imam Akbar, Farah Amira Ghazali, Ardiyansyah Syahrom, Tunku Kamarul
Summary: Permeability is an important factor to consider in the design of porous scaffolds for cell migration and bone tissue regeneration. This study developed a porous scaffold based on the morphological indices of cancellous bone and analyzed fluid flow through the scaffold using computational fluid dynamics. The permeability of the scaffold was compared to that of natural cancellous bone and different scaffold types. The results showed that the Negative Schwarz Primitive (NSP) scaffold had similar permeability to natural cancellous bone and could be manipulated by changing the curvature to support cell migration and tissue regeneration.
Article
Orthopedics
Jia Xu, Junjie Shen, YunChu Sun, Tianyi Wu, Yuxin Sun, Yimin Chai, Qinglin Kang, Biyu Rui, Gang Li
Summary: This study evaluated an alternative in vivo prevascularization approach using preimplant-prepared macroporous beta-tricalcium phosphate scaffolds for bone regeneration. The prevascularization treatment significantly enhanced vascular formation and bone consolidation, upregulating expression of important markers for bone regeneration.
JOURNAL OF ORTHOPAEDIC TRANSLATION
(2022)
Article
Engineering, Biomedical
Liaobing Xin, Xiaowen Zheng, Jianmin Chen, Sentao Hu, Yilun Luo, Qunzi Ge, Xiaoying Jin, Lie Ma, Songying Zhang
Summary: This study explores an acellular biomaterial called SDF-1 alpha/E7-modified collagen scaffold (CES), which enables near-complete endometrium regeneration and fertility restoration by mobilizing endogenous MSCs. The results demonstrate that CES can overcome the traditional limitations of cell-based therapies and serve as a clinically feasible and cell-free strategy with high therapeutic efficiency for IUA treatment.
ADVANCED HEALTHCARE MATERIALS
(2022)
Article
Engineering, Biomedical
Xinshuai Gao, Honghua Wang, Shifang Luan, Guangyuan Zhou
Summary: This article introduces a new polymer material, PAEK-COOH, which is synthesized and fabricated into hierarchically controllable porous scaffolds via low-temperature 3D printing. The prepared scaffolds exhibit comparable mechanical strength to trabecular bone and the nanoporous surface promotes cellular adhesion and hydroxyapatite mineralization through electrostatic interaction. In vivo experiments demonstrate the superior osseointegration of the PAEK-COOH scaffolds compared to PEEK, without the need for additional active ingredients.
ADVANCED HEALTHCARE MATERIALS
(2022)
Article
Polymer Science
Banafsheh Safari, Marziyeh Aghazadeh, Leila Roshangar, Ayuob Aghanejad, Soodabeh Davaran
Summary: This study reports the fabrication and evaluation of a bioactive hybrid scaffold collagen/P-PCL for bone tissue engineering. The scaffold showed biocompatibility, osteoconductivity, and osteoinductivity, supporting the proliferation and differentiation of AD-MSCs.
EUROPEAN POLYMER JOURNAL
(2022)
Article
Materials Science, Biomaterials
Yiwen Zhang, Zhixiang Li, Ziqi Wang, Bomin Yan, Ao Shi, Jinnuo Xu, Jianzhong Guan, Li Zhang, Pinghui Zhou, Yingji Mao
Summary: The CSMA/??-TCP composite hydrogel has strong mechanical properties and cell compatibility, promoting proliferation and bone regeneration of BMSCs, upregulating the expression of various osteogenic proteins and verifying the regulatory mechanism of the Hippo signaling pathway.
BIOMATERIALS ADVANCES
(2022)
Article
Engineering, Biomedical
Sareh Abolhassani, Mahdokht Hossein-Aghdaei, Bita Geramizadeh, Negar Azarpira, Farhad Koohpeyma, Mahnaz Gholami, Aliakbar Alizadeh
Summary: This study aimed to develop a controlled-shape hydrogel and apply conditioned-media of mesenchymal stromal cells (CM-MSCs) to improve primary hepatocyte functions. The patterned alginate hydrogel was produced using an electrodeposition method. The presence of CM-MSCs significantly increased urea synthesis in the patterned hydrogel alginate compared to 2D culture after 3 days.
JOURNAL OF BIOMATERIALS APPLICATIONS
(2023)
Review
Surgery
Zahra Beyzaei, Zahra Bagheri, Sara Karimzadeh, Bita Geramizadeh
Summary: This study conducted a systematic review and meta-analysis to investigate the long-term outcomes of liver transplantation in patients with hepatic glycogen storage disease (GSD). The results showed that most GSD patients experienced significant improvement after liver transplantation. However, further research is needed to confirm these findings.
CLINICAL TRANSPLANTATION
(2023)
Article
Microbiology
Saeede Soleimanian, Ramin Yaghobi, Mohammad Hossein Karimi, Bita Geramizadeh, Jamshid Roozbeh
Summary: This study found that CMV reactivation in kidney transplant recipients is associated with increased production of inflammatory proteins such as IL-6 and IL-10, the formation of cytotoxic granules, and a decrease in the frequency of a specific NK cell subset. These immune signatures changes can be helpful for the timely management of CMV infection.
CURRENT MICROBIOLOGY
(2023)
Article
Parasitology
Narjes Yektaeian, Shahrokh Zare, Amir Hosein Radfar, Gholamreza Hatam
Summary: This study evaluated the role of superparamagnetic iron oxide nanoparticles (SPIONs) in cell culture for tracking labeled Leishmania major in fibroblasts. The results showed that SPIONs can accurately and rapidly label Leishmania parasites invaded into fibroblasts. These findings can provide new insights into the diagnosis, pathogenesis, and treatment of cutaneous leishmaniasis.
JOURNAL OF PARASITOLOGY RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Neda Moradian, Gholamreza Hatam, Azadeh Hamedi, Ardalan Pasdaran
Summary: This study evaluated the antileishmanial potential of Carex pendula Huds. methanolic extract and its fractions against Leishmania major cutaneous infection. The ethyl acetate fraction showed the best activity, with an IC50 = 1.627 +/- 0.211 mg/mL. Nine chemical compounds, including flavonols, flavanonols, and flavan derivatives, were identified in this fraction. The in vivo and in vitro experiments confirmed the considerable antileishmanial activity of the ethyl acetate fraction.
CHEMICAL BIOLOGY & DRUG DESIGN
(2023)
Article
Engineering, Biomedical
Fatemeh Parsaee, Aliakbar Alizadeh, Mostafa Rezaee, Omid Alavi, Hamed Alipour
Summary: This study investigated the properties of the PRF scaffold with tricalcium phosphate nanoparticles in socket preservation and found that it promotes bone regeneration. The experimental results showed that PRF/TCP scaffold accelerates bone formation, resulting in a higher amount of bone tissue and collagen fibers. The mechanical and chemical tests also confirmed that the addition of TCP to the PRF scaffold reduces swelling and prolongs degradation time. In conclusion, the injectable PRF\TCP hydrogel is a promising candidate for bone repair and regeneration.
JOURNAL OF BIOMATERIALS APPLICATIONS
(2023)
Review
Biochemistry & Molecular Biology
Zahra Abpeikar, Ali Akbar Alizadeh, Leila Rezakhani, Vahid Ramezani, Arash Goodarzi, Mohsen Safaei
Summary: Material engineering is crucial in medical applications of materials. Recognition sites on biomaterial surfaces play a key role in enhancing tissue engineering scaffolds' efficiency. Synthetic ligands like nucleic acid aptamers have advantages in terms of synthesis ease, minimal immunogenicity, specificity, and stability. This study reviews the advantages of nucleic acid aptamers in tissue engineering, such as attracting endogenous stem cells for tissue regeneration and improving controlled drug delivery.
MOLECULAR BIOTECHNOLOGY
(2023)
Article
Materials Science, Biomaterials
Mojdeh Salehi Namini, Somayeh Ebrahimi-Barough, Jafar Ai, Hossein Kargar Jahromi, Elmira Mikaeiliagah, Mahmoud Azami, Naghmeh Bahrami, Nasrin Lotfibakhshaiesh, Jamileh Saremi, Sadegh Shirian
Summary: A novel tissue-engineered nerve guide conduit structure encapsulated with human endometrial stem cell (EnSC) derived exosomes was developed, which promoted nerve regeneration in rat sciatic nerve defects. In vivo studies showed that the encapsulated exosomes significantly benefited nerve regeneration and improved functional recovery. These findings suggest that encapsulated EnSC-derived exosomes in a nerve guide conduit have potential as a cell-free treatment for peripheral nerve defects.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2023)
Article
Chemistry, Multidisciplinary
Nima Beheshtizadeh, Alireza Salimi, Mahsa Golmohammadi, Javad Mohajer Ansari, Mahmoud Azami
Summary: One of the crucial factors for wound healing is the promotion of angiogenesis, which is often impaired in diabetic wounds due to lack of pro-angiogenic factors or increase in anti-angiogenic factors. Incorporating small RNA molecules like microRNAs (miRNAs) and small interfering RNAs (siRNAs) into wound treatments can potentially enhance angiogenesis. This study aims to identify novel antagonists for miRNAs and siRNAs that target multiple genes to promote angiogenesis and wound healing in diabetic ulcers.
Review
Engineering, Biomedical
Hengameh Dortaj, Ali Akbar Alizadeh, Negar Azarpira, Lobat Tayebi
Summary: The administration of stem cells in regenerative medicine has emerged as a potential treatment option for many diseases. Many questions remain about the survival and biology of SC after transplantation. Non-invasive SC monitoring has been updated to assess the viability and biology of SC transplantation, and the use of nanoparticles has become important in many aspects of SC tracking.
REGENERATIVE ENGINEERING AND TRANSLATIONAL MEDICINE
(2023)
Article
Parasitology
Hamid Mahmoodpour, Adel Spotin, Gholam Reza Hatam, Ali Pourmahdi Ghaemmaghami, Seyed Mahmoud Sadjjadi
Summary: This study aimed to investigate the activity and safety of hydroalcoholic extracts of E. microtheca against E. granulosus in vitro and ex vivo. The results showed that the prepared extracts exhibited strong protoscolicidal effects in both in vitro and ex vivo tests.
EXPERIMENTAL PARASITOLOGY
(2023)
Article
Pharmacology & Pharmacy
Sepideh Nezhadi, Parisa Norouzi, Azadeh Rasouli, Hamid Akbari Javar, Seyed Nasser Ostad, Farid Dorkoosh
Summary: This study aims to design a co-delivery system to suppress the growth and migration of triple negative breast cancer (TNBC) cells. The co-loaded mixed micelles of paclitaxel (PTX) and regorafenib (REG) showed promising potential in inhibiting proliferation and migration of TNBC cells and enhancing the therapeutic efficacy of PTX.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Neurosciences
Amin Firoozi, Aliakbar Alizadeh, Asadollah Zarifkar, Tahereh Esmaeilpour, Mohammad Reza Namavar, Omid Alavi, Farzaneh Dehghani
Summary: This study aimed to investigate the effects of conditioned medium of human umbilical cord mesenchymal stem cells and platelet-rich plasma on AD model rats. The results showed that CM improved learning and memory impairments as well as the structure of the hippocampus.
IBRO NEUROSCIENCE REPORTS
(2023)
Review
Medicine, Research & Experimental
Sanaz Dastghaib, Farhad Koohpeyma, Mesbah Shams, Forough Saki, Aliakbar Alizadeh
Summary: Compared to the well-studied regulation of calcium homeostasis, our understanding of phosphate homeostasis is limited. Fibroblast growth factor 23 (FGF23) has recently gained attention as a key regulator of phosphate homeostasis, and further research is needed to fully understand its functions and interactions with other factors involved in mineral homeostasis.
CLINICAL AND EXPERIMENTAL MEDICINE
(2023)