Article
Biochemistry & Molecular Biology
Marketa Havrdova, Iztok Urbancic, Katerina Barton Tomankova, Lukas Malina, Janez Strancar, Athanasios B. Bourlinos
Summary: The study reveals that QCDs can penetrate the cell nucleus and exhibit concentration-dependent effects internally. QCDs have different impacts on NIH/3T3 and L929 cells, with the former experiencing changes in cell cycle profile and the latter leading to cellular death. Additionally, the presence of QCDs in the nucleus affects the intranuclear environment and causes fluorescence blue shifts.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Polymer Science
Lucija Jurko, Matej Bracic, Silvo Hribernik, Damjan Makuc, Janez Plavec, Filip Jerenec, Sonja Zabkar, Nenad Gubeljak, Alja Stern, Rupert Kargl
Summary: This study explored the succinylation of primary amines in a synthetic polyelectrolyte, polyallylamine, and its impact on cytotoxicity and antibacterial activity. The results showed that reducing the degree of succinylation decreased cytotoxicity but significantly reduced antibacterial efficacy.
Article
Toxicology
Indranil De, S. Rajesh, Avneet Kour, Henna Wani, Prashant Sharma, Jiban Jyoti Panda, Manish Singh
Summary: The study revealed that exposure to CaC2 reduces cell viability, alters cellular morphology, and increases intracellular ROS levels, leading to apoptosis. Consequently, it is suggested to discontinue the use of CaC2 as a fruit ripener due to its potential association with severe health risks.
TOXICOLOGY MECHANISMS AND METHODS
(2021)
Article
Cell Biology
Lingling Jiang, Yan Qi, Xianghan Kong, Runnan Wang, Jianfei Qi, Francis Lin, Xueling Cui, Zhonghui Liu
Summary: The study showed that Activin A can regulate the migration and adhesion of fibroblasts, inducing chemotactic migration of cells via ERK signaling.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Hyo-Won Han, Ara Joe, Eue-Soon Jang
Summary: The study confirmed the cytotoxicity of residual CTAB surfactant on gold nanorods, and demonstrated that amine-functionalized fluorescence dyes could effectively substitute CTAB to reduce toxicity. The resulting products showed excellent surface-enhanced Raman scattering performance and could detect a few cancer cells.
JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
(2021)
Article
Spectroscopy
Gaurav Kulkarni, Preetam Guha Ray, Shreyasi Das, Souvik Biswas, Santanu Dhara, Soumen Das
Summary: The study utilized Raman spectroscopy guided approach for biochemical evaluation of cell-matrix interaction, revealing that EDC crosslinked gels exhibited superior cell proliferation compared to GTA counterparts.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2021)
Article
Chemistry, Multidisciplinary
Thanh Lam Bui, Ngoc Thanh Ho, Xuan Vuong Thi Thanh Ho, Dinh Nghi Ngo, Soon Hyuk Lim, Sang Jun Son, Seung Man Noh, Sang-Woo Joo
Summary: The optical properties of anisotropic gold nanorod arrays inside anodic aluminum oxide substrates enhance longitudinal absorption intensities and increase hyperthermia cancer cell killing at 42.1 degrees C under photothermal laser exposures at 671 nm.
CHEMICAL COMMUNICATIONS
(2021)
Article
Multidisciplinary Sciences
Ning Zhou, Yuxin Yang, Xin Guo, Jue Gong, Zhangxing Shi, Zongyin Yang, Hao Wu, Yixiao Gao, Ni Yao, Wei Fang, Pan Wang, Limin Tong
Summary: This study reports the direct observation of lasing in microfiber-coupled single plasmonic nanoparticles enabled by strong mode coupling. The results show that single-mode laser emission from the nanoparticles can be achieved at room temperature with low threshold and narrow linewidth.
Article
Medicine, Research & Experimental
Davide Campoccia, Stefano Ravaioli, Spartaco Santi, Valentina Mariani, Cristina Santarcangelo, Anna De Filippis, Lucio Montanaro, Carla Renata Arciola, Maria Daglia
Summary: Propolis exhibits antimicrobial, antioxidant, anti-inflammatory, and anticancer activities, influenced by various factors. The Multi Dynamic Extraction Method (MED) can improve the reproducibility of propolis extracts. The study shows that propolis has mild cytotoxicity towards cancer cells, with some selective activity observed, highlighting the importance of assessing selectivity when screening for anticancer drug candidates.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Engineering, Chemical
M. Concepcion Matesanz, Mercedes Villa-Carvajal, Javier Linares, Sonia Morante-Zarcero, Isabel Sierra, Eva Barreno, Myriam Catala, M. Teresa Portoles
Summary: The study analyzed the biocompatibility and chemical composition of a microalga isolated from lichen, finding high protein content and antioxidant capacity but some effects on cells at high concentrations. The results suggest that this microalga is suitable for development in food or pharmaceutical applications, with further research needed for its potential use as an antitumor agent.
Article
Nanoscience & Nanotechnology
Daniel Zambo, Pascal Rusch, Franziska Lubkemann, Nadja C. Bigall
Summary: By optimizing the synthesis of noble-metal nanorods and cryoaerogels, functional macrostructures with prominent electrocatalytic activity can be constructed.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Chemistry, Multidisciplinary
Brian Hyun-jong Lee, Nicholas A. Kotov, Gaurav Arya
Summary: Gold nanorod dimers bridged by double-stranded DNA exhibit variable chiral configurations depending on the chemical and ionic properties of the solvent medium. The chiral behavior is governed by the twist-stretch coupling of the DNA and intermolecular interactions between nanorods. Changes in depletant or ion concentration of the solvent medium can lead to different classes of configurational responses by the dimers, including chirality-switching behavior.
Article
Environmental Sciences
Bahar Akyuz Yilmaz, Tugce Karaduman, Mehmet Cicek, Ilgaz Akata, Murat Kaya
Summary: Researchers prepared biodegradable composite films by incorporating Pisolithus arhizus spores into the chitosan matrix, showing improved thermal stability and antioxidant activity. The addition of PS significantly increased water solubility, while the biodegradation time of the composite films depended on the PS content.
WASTE AND BIOMASS VALORIZATION
(2021)
Article
Chemistry, Multidisciplinary
Heyou Zhang, Yawei Liu, Muhammad Faris Shahin Shahidan, Calum Kinnear, Fatemeh Maasoumi, Jasper Cadusch, Eser Metin Akinoglu, Timothy D. James, Asaph Widmer-Cooper, Ann Roberts, Paul Mulvaney
Summary: A new method is reported for precisely assembling vertically oriented, single gold nanorods, controlling their orientation. Through electrophoretic deposition, arrays with over one million visually resolvable vertical nanorods per square millimeter can be assembled.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Physics, Applied
Spyridon Korkos, Ville Jantunen, Kai Arstila, Timo Sajavaara, Aleksi Leino, Kai Nordlund, Flyura Djurabekova
Summary: This study demonstrates that highly energetic ions can be utilized to not only modify the shape of metal nanoparticles, but also manipulate the orientation of nanorods. Through a combination of imaging and experimental observation, the complex mechanism of nanorod re-orientation is revealed.
APPLIED PHYSICS LETTERS
(2022)
Article
Chemistry, Analytical
Sallahuddin Panhwar, Hasan Ilhan, Syeda Sara Hassan, Adem Zengin, Ismail Hakki Boyaci, Ugur Tamer
Article
Electrochemistry
Sallahuddin Panhwar, Adnan Aftab, Hareef Ahmed Keerio, Hasan Ilhan, Mohammad Sarmadivaleh, Ugur Tamer
Summary: Climate change is causing the evolution of novel microbes in the environment, while nanoscience is rapidly advancing to provide environmentally friendly engineering solutions for detecting these microbes in blood and water.
JOURNAL OF THE ELECTROCHEMICAL SOCIETY
(2021)
Article
Chemistry, Applied
Pervin Ari Akin, Kubra Elif Tayfun, Ugur Tamer, Ismail Hakki Boyaci
Summary: This study evaluated the impact of adding finely ground tea fiber on wheat dough and bread. The results showed that tea fiber affected various properties of the dough and bread, with 2.5% of tea fiber being recommended as a fiber-enriching agent in bread making. The addition of tea fiber also influenced characteristics such as loaf volume, specific volume, and sensory parameters of the bread.
Article
Chemistry, Analytical
Hilal Torul, Ece Yarali, Ece Eksin, Abhijit Ganguly, John Benson, Ugur Tamer, Pagona Papakonstantinou, Arzum Erdem
Summary: Paper-based electrochemical biosensors were developed for rapid and sensitive detection of microRNAs related to early diagnosis of lung cancer. The biosensors showed high selectivity and sensitivity for target miRNAs in the presence of mismatched or noncomplementary sequences.
Article
Biophysics
Hasan Ilhan, Emine Kubra Tayyarcan, Mehmet Gokhan Caglayan, Ismail Hakki Boyaci, Necdet Saglam, Ugur Tamer
Summary: The study investigated the analytical performance of bacteriophages for Salmonella Enteritidis using lateral flow assay (LFA) technique, and found that bacteriophages could be an alternative analyte-specific agents to antibodies in lateral flow assay testing of bacteria with comparable sensitivity, specificity, and accuracy. The combination of Surface Enhanced Raman Spectroscopy (SERS) and colorimetric measurements allowed for sensitive quantitation of target bacteria in less than 30 minutes.
BIOSENSORS & BIOELECTRONICS
(2021)
Article
Agriculture, Dairy & Animal Science
Shuangyan Ding, Hailiang Hu, Xianglin Yue, Kaiwen Feng, Xiaoyu Gao, Qiuling Dong, Mingqi Yang, Ugur Tamer, Ganhui Huang, Jinsheng Zhang
Summary: A new detection method based on quantum dots was developed to detect Salmonella in milk, with a detection limit 10 times better than conventional sandwich ELISA. The biosensor showed good specificity for detecting Salmonella.
JOURNAL OF DAIRY SCIENCE
(2022)
Article
Chemistry, Analytical
Almira Ramanaviciene, Anton Popov, Ema Baliunaite, Benediktas Brasiunas, Asta Kausaite-Minkstimiene, Ugur Tamer, Gailute Kirdaite, Eiva Bernotiene, Ali Mobasheri
Summary: This study presents the development of a specific magnetic immunoassay method for the determination of hGH concentration in serum. The method has a low limit of detection, clinically relevant linear range, and negligible non-specific binding. Important technical solutions for the development of this sandwich-type colorimetric magneto-immunoassay are discussed.
Article
Chemistry, Applied
Nazife Nur Yazgan, Tugba Bulat, Ali Topcu, Fahriye Ceyda Dudak, Ismail Hakki Boyaci, Ugur Tamer
Summary: A new SERS-based method was developed for detecting plasmin activity, using specific peptide sequences and SERS substrates to determine enzyme activity and obtaining a graph of plasmin concentration versus SERS intensity changes. LOD and LOQ values were calculated, and the repeatability and recovery of the method were tested for plasmin spiked milk samples.
Article
Pharmacology & Pharmacy
Sibel Ilbasmis-Tamer, Eylul Su Saral-Acarca, Serdar Tort, Cigdem Yucel, Ugur Tamer, Fusun Acarturk
Summary: In this study, electrospun nanofibers were prepared as a carrier to release rutin, which has poor solubility but exhibits various activities such as antiviral, anticancer, anti-inflammatory, and heart disease protective activities. To enhance the activity of rutin, starch-coated copper nanoparticles were added to the nanofibers. The results showed that the nanofibers containing starch-coated copper nanoparticles and rutin exhibited no cytotoxicity and had good biocompatibility.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Electrochemistry
Sevda Akay Sazaklioglu, Hilal Torul, Hafize Seda Vatansever, Ugur Tamer, Huseyin Celikkan
Summary: In this study, a biosensor for detecting low concentrations of exosomes was fabricated and utilized. The biosensor captured exosomes on the electrode surface using immunological recognition strategies, and label-free detection was successfully achieved. The proposed biosensor demonstrated a sensitive and reliable impedimetric method for detecting exosomes within a working range of 3.7 x 10( )3 to 3.7 x 10(8) particles/mL.
JOURNAL OF APPLIED ELECTROCHEMISTRY
(2023)
Article
Pharmacology & Pharmacy
Basak Simitcioglu, Isik Didem Karagoz, Sibel Ilbasmis-Tamer, Ugur Tamer
Summary: This study found that the molecular weight of the polymer and the terminal groups can affect the surface morphology of nanoparticles and the drug encapsulation efficiency. Resomers with acid terminal function showed higher encapsulation and reaction efficiency. High molecular weight Resomers exhibited selective cytotoxicity, especially in the treatment of prostate cancer, suggesting potential for extended-release drug delivery systems.
PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY
(2022)
Article
Chemistry, Analytical
Uzeyir Dogan, Ferah Sucularli, Ender Yildirim, Demet Cetin, Zekiye Suludere, Ismail Hakki Boyaci, Ugur Tamer
Summary: Pathogen detection is still a challenging issue in public health, especially in food products. Researchers have developed a method using a capillary-driven microfluidic chip and surface-enhanced Raman scattering measurements for rapid detection of Escherichia coli. This method can detect very low concentrations of E. coli within 60 minutes.
Article
Pharmacology & Pharmacy
Sibel Ilbasmis-Tamer, Mustafa Turk, Sefika Evran, Ismail Hakki Boyaci, Hakan Ciftci, Ugur Tamer
Summary: “The objective of this study was to prepare stable starch-coated copper nanoparticles (Cu-SNPs) by a green synthesis method and evaluate their apoptotic and necrotic effects on Capan 1 pancreatic cancer cell line. The Cu-SNPs showed antimicrobial effects on Staphylocossus and Enterococcus and exhibited cytotoxic, necrotic, and apoptotic effects on the Capan 1 cell line.”
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Chemistry, Analytical
Vijayalaxmi Manoharan, Rui Rodrigues, Sara Sadati, Marcus J. Swann, Neville Freeman, Bowen Du, Ender Yildirim, Ugur Tamer, Theodoros N. Arvanitis, Dmitry Isakov, Ali Asadipour, Jerome Charmet
Summary: Researchers have developed an application called PocketEC, which can interface with multiple potentiostat ICs. Through Bluetooth technology, PocketEC can be connected to evaluation boards, open-source potentiostats, and custom-built potentiostats. The versatility of PocketEC was demonstrated by comparing its performance with standard benchtop potentiostats using various experiments. The application, along with its companion devices, can be used for a variety of wearable or portable electrochemical sensing applications.
Article
Chemistry, Analytical
Hilal Torul, Elif Calik Kayis, I. Hakki Boyaci, Ugur Tamer
Summary: A unique electrochemiluminescence (ECL) sensor combined with a paper electrode was proposed for the detection of phenylalanine in blood samples. The method achieved excellent selectivity by converting phenylalanine into ammonia and using it as a co-reactant to produce an ECL signal. Using AuNP decorated paper electrodes, the ammonia molecules were brought to the working electrode, cutting off contact with the sample matrix. The developed method showed a linear increase of ECL signals with logarithmic l-Phe concentrations, with a high correlation coefficient and low limit of detection. The method was successfully applied for l-Phe detection in reference blood samples, showing good recovery rates compared to a comparison method.
