Journal
ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY
Volume 43, Issue 1, Pages 40-49Publisher
TAYLOR & FRANCIS LTD
DOI: 10.3109/21691401.2013.837475
Keywords
cryogels; biodegradable; drug release; thermoresponsive
Categories
Funding
- Turkish Academy of Sciences (TUBA)
- NoE. EXPERTISSUES (UE) [500283-2]
- Spanish Ministry of Economy and Competitiveness [MAT2010-18155]
- Eugenio Rodriguez Pascual Foundation project
Ask authors/readers for more resources
NIPA and HEMA-lactate-Dextran-based biodegradable and thermoresponsive cryogels were synthesized at different compositions by cryogelation. Chemical and morphological properties of the HEMA-lactate-Dextran-co-NIPA cryogel matrices were demonstrated by FTIR, SEM, and ESEM. Thermoresponsivity of the prepared cryogels was investigated by DSC, imaging NMR, and swelling studies. For possible use of the cryogels in potential bone tissue engineering applications, either hydrophobic simvastatin was embedded, or hydrophilic simvastatin was incorporated in the cryogels. Release profiles of simvastatin delivering cryogel scaffolds depending on their composition, hydrophobicity or hydrophilicity of loaded simvastatin and the medium temperature were demonstrated.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available