Article
Gastroenterology & Hepatology
Arun Jose, Elizabeth J. Kopras, Shimul A. Shah, Jean M. Elwing
Summary: This study investigates the practice patterns for adjusting targeted therapy after liver transplantation (LT) in patients with portopulmonary hypertension (POPH). The results reveal heterogeneity in the practice patterns, with some physicians adjusting therapy immediately after LT and others favoring serial integrated cardiopulmonary testing to guide therapy adjustments. The study highlights the need for further research to optimize treatment strategies for POPH patients.
LIVER TRANSPLANTATION
(2023)
Review
Gastroenterology & Hepatology
Hitoshi Yoshiji, Sumiko Nagoshi, Takemi Akahane, Yoshinari Asaoka, Yoshiyuki Ueno, Koji Ogawa, Takumi Kawaguchi, Masayuki Kurosaki, Isao Sakaida, Masahito Shimizu, Makiko Taniai, Shuji Terai, Hiroki Nishikawa, Yoichi Hiasa, Hisashi Hidaka, Hiroto Miwa, Kazuaki Chayama, Nobuyuki Enomoto, Tooru Shimosegawa, Tetsuo Takehara, Kazuhiko Koike
Summary: The latest edition of the clinical practice guidelines for liver cirrhosis includes new background and future research questions, as well as updates based on international standards and recent findings. It covers various aspects of liver cirrhosis treatment, complication management, and clinically important issues, incorporating the latest information and references to international guidelines.
JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Oncology
Lucia Calthorpe, Fernanda Romero-Hernandez, Megan Casey, Miguel Nunez, Patricia C. Conroy, Kenzo Hirose, Alex Kim, Kimberly Kirkwood, Ajay V. Maker, Carlos Corvera, Eric Nakakura, Adnan Alseidi, Mohamed Abdelgadir Adam
Summary: This study analyzed the management and survival of patients with malignant peritoneal mesothelioma (MPM) and found that cytoreductive surgery (CRS) with hyperthermic intraperitoneal chemotherapy (HIPEC) is an effective therapy. Over time, there has been an increase in the proportion of patients undergoing CRS-HIPEC and a decrease in the proportion of patients receiving no treatment, accompanied by an improvement in overall survival.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Gastroenterology & Hepatology
Hitoshi Yoshiji, Sumiko Nagoshi, Takemi Akahane, Yoshinari Asaoka, Yoshiyuki Ueno, Koji Ogawa, Takumi Kawaguchi, Masayuki Kurosaki, Isao Sakaida, Masahito Shimizu, Makiko Taniai, Shuji Terai, Hiroki Nishikawa, Yoichi Hiasa, Hisashi Hidaka, Hiroto Miwa, Kazuaki Chayama, Nobuyuki Enomoto, Tooru Shimosegawa, Tetsuo Takehara, Kazuhiko Koike
Summary: The latest edition of the clinical practice guidelines for liver cirrhosis integrates new findings in clinical treatment, aligns with international standards, and includes data based on clinical practice evidence from Japan. The guidelines encompass new approaches to diagnosis, treatment, and management of complications, with detailed explanations on topics such as nutritional therapy.
HEPATOLOGY RESEARCH
(2021)
Article
Oncology
Shoji Kubo, Hiroji Shinkawa, Yoshinari Asaoka, Tatsuya Ioka, Hiroshi Igaki, Namiki Izumi, Takao Itoi, Michiaki Unno, Masayuki Ohtsuka, Takuji Okusaka, Masumi Kadoya, Masatoshi Kudo, Takashi Kumada, Norihiro Kokudo, Michiie Sakamoto, Yoshihiro Sakamoto, Hideyuki Sakurai, Tadatoshi Takayama, Osamu Nakashima, Yasushi Nagata, Etsuro Hatano, Kenichi Harada, Takamichi Murakami, Masakazu Yamamoto
Summary: This paper presents the first version of clinical practice guidelines for intrahepatic cholangiocarcinoma (ICC) established by the Liver Cancer Study Group of Japan. The guidelines cover various aspects of ICC, including etiology, pathology, diagnosis, and treatment, and provide a treatment algorithm and background statements.
Review
Orthopedics
Delphine Sorondo, Cyrille Delpierre, Pierre Cote, Louis-Rachid Salmi, Christine Cedraschi, Anne Taylor-Vaisey, Nadege Lemeunier
Summary: The study found barriers and facilitators to the utilization of clinical practice guidelines by healthcare providers involved in the assessment and management of musculoskeletal disorders. The main barriers included disagreement between recommendations and patient expectations, guidelines not being specific to individual patients, lack of familiarity with certain terms or models, time-consuming processes, and variations in guideline methods. The main facilitators included clinicians' interest in evidence-based practice, perception that guidelines improve triage, diagnosis, and management, time efficiency, and standardized language.
BMC MUSCULOSKELETAL DISORDERS
(2021)
Review
Gastroenterology & Hepatology
Katsutoshi Tokushige, Kenichi Ikejima, Masafumi Ono, Yuichiro Eguchi, Yoshihiro Kamada, Yoshito Itoh, Norio Akuta, Masato Yoneda, Motoh Iwasa, Masashi Yoneda, Motoyuki Otsuka, Nobuharu Tamaki, Tomomi Kogiso, Hiroto Miwa, Kazuaki Chayama, Nobuyuki Enomoto, Tooru Shimosegawa, Tetsuo Takehara, Kazuhiko Koike
Summary: Nonalcoholic fatty liver disease (NAFLD) is a serious public health issue in Japan, with nonalcoholic steatohepatitis (NASH) being a progressive form that can lead to liver cirrhosis and increase the risk of hepatocellular carcinoma. The most common cause of death in NAFLD patients is cardiovascular disease.
JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Endocrinology & Metabolism
Reagan A. Collins, Natalia Chaves, Gillian Lee, Jordan M. Broekhuis, Benjamin C. James
Summary: The 2015 ATA guidelines led to a change in overall practice in surgical management of PTC toward increasing TL. Both urban and rural settings had an increase in TL following the guideline change, emphasizing the importance of clinical practice guidelines to ensure best practice in both rural and urban settings.
Article
Medicine, General & Internal
Dongdong Tang, Yuyang Zhang, Wei Zhang, Guanjian Li, Hao Geng, Hui Jiang, Xiansheng Zhang
Summary: Although sexual function is crucial for overall human health, sexual dysfunction, especially in female patients, has been inadequately addressed by urologists and andrologists in China. This survey study reveals a lack of knowledge and understanding of sexual dysfunction among Chinese urologists and andrologists, highlighting the need for more comprehensive training in this area.
Review
Nutrition & Dietetics
Sofia Montemayor, Silvia Garcia, Margalida Monserrat-Mesquida, Josep A. Tur, Cristina Bouzas
Summary: This scoping review compiles dietary patterns, foods, and nutrients to ameliorate non-alcoholic fatty liver disease (NAFLD). The findings suggest that a hypocaloric Mediterranean diet, sugar-free coffee consumption, and adequate intake of dietary fiber can improve NAFLD.
Article
Medicine, General & Internal
Armaan Singh, Max J. Hyman, Parth K. Modi
Summary: In this cross-sectional study, it was found that advanced practice clinicians (APCs) in the US receive lower financial benefits from pharmaceutical and medical device companies compared to physicians. The study also reveals that the average value of industry interactions with APCs is lower than that with physicians.
Review
Cardiac & Cardiovascular Systems
Sarah Landry, Shannon Ip, Jennifer Shiu, Tammy J. Bungard
Summary: This study found a high uptake of direct oral anticoagulants (DOACs) for acute VTE treatment, with most prescribed in accordance with product monographs. At the initial visit to the VTE clinic, 21.5% of patients had therapy changes, with the majority switching from low molecular weight heparin/warfarin to a DOAC.
JOURNAL OF THROMBOSIS AND THROMBOLYSIS
(2022)
Article
Telecommunications
Liqin Yang, Liang Zhang
Summary: The study focuses on using business process modeling technology to model medical treatment processes and proposes an integrated framework based on treatment patterns. The efficiency of modeling medical treatment processes is enhanced by summarizing and applying treatment patterns. Empirical analysis shows that executable medical treatment processes of CPGs provide guidance for physicians, helping them in their daily work.
CHINA COMMUNICATIONS
(2021)
Article
Cardiac & Cardiovascular Systems
Dominick J. Angiolillo, David Erlinge, Jose Luis Ferreiro, Chris P. Gale, Kurt Huber, Giuseppe Musumeci, Jean-Philippe Collet
Summary: This survey indicates that the implementation of 2020 NSTE-ACS guidelines on early invasive management and pre-treatment is heterogeneous, potentially due by local logistical constraints.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2023)
Article
Anesthesiology
Lori D. Bash, Wynona Black, Vladimir Turzhitsky, Richard D. Urman
Summary: Active pharmacological reversal of neuromuscular blockade in US adult outpatients increased following the introduction of sugammadex, but there remains significant practice variability. The relationship between patient-, procedural-, and environmental-level characteristics and NMB management is rapidly evolving.
ANESTHESIA AND ANALGESIA
(2021)
Letter
Dermatology
Rachel I. Vogel, Patricia I. Jewett, Rehana L. Ahmed, DeAnn Lazovich
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2022)
Article
Dermatology
Ashley E. Stenzel, Jonathan Miller, Shernan G. Holtan, Katherine Brown, Rehana L. Ahmed, DeAnn Lazovich, Rachel Vogel
Summary: Long-term melanoma survivors are more likely to meet American Cancer Society physical activity guidelines than population controls, but almost 50% do not meet the recommendations. This finding is concerning as physical activity is known to improve quality of life and survival among cancer survivors. There are still opportunities to promote physical activity among melanoma survivors.
ARCHIVES OF DERMATOLOGICAL RESEARCH
(2023)
Article
Oncology
Andrew Etteldorf, Shannon Rotolo, Ramy Sedhom, Rachel Vogel, Anne Blaes, Stacie B. Dusetzina, Beth Virnig, Arjun Gupta
Summary: The study aimed to determine if a single pharmacy consistently offered the lowest price for symptom control medications, as shopping around at different pharmacies can add time and logistic burden. The results showed that no single pharmacy consistently offered the lowest price for medications used to manage two common cancer-associated symptoms.
JCO ONCOLOGY PRACTICE
(2022)
Article
Oncology
Jesse Boumelha, Sophie de Carne Trecesson, Emily K. Law, Pablo Romero-Clavijo, Matthew A. Coelho, Kevin W. Ng, Edurne Mugarza, Christopher Moore, Sareena Rana, Deborah R. Caswell, Miguel Murillo, David C. Hancock, Prokopios P. Argyris, William L. Brown, Cameron Durfee, Lindsay K. Larson, Rachel Vogel, Alejandro Suarez-Bonnet, Simon L. Priestnall, Philip East, Sarah J. Ross, George Kassiotis, Miriam Molina-Arcas, Charles Swanton, Reuben Harris, Julian Downward
Summary: This study develops a mouse model of immunogenic KRAS-mutant lung cancer to facilitate the investigation of optimal combinations of targeted therapies with immunotherapies.
Article
Public, Environmental & Occupational Health
Rebekah H. Nagler, Rachel Vogel, Alexander J. Rothman, Marco C. Yzer, Sarah E. Gollust
Summary: Regardless of individuals' level of trust in news media or research literacy, they are vulnerable to the downstream effects of exposure to conflicting health information. Targeted health communication interventions are needed to improve messaging about emerging science and, in turn, increase receptivity to public health recommendations.
HEALTH EDUCATION & BEHAVIOR
(2023)
Article
Health Care Sciences & Services
Patricia Jewett, Carrie Henning-Smith, DeAnn Lazovich, Rehana L. Ahmed, Rachel Vogel
Summary: The purpose of this study was to compare activities at the time of a sunburn between rural and urban residents in the United States. The study found that rural residents were more likely to experience sunburn while working or working outside the house, while urban residents were more likely to experience sunburn while exercising or sunbathing. These findings suggest that preventing incidental sun exposures during outdoor-focused rural occupations and work outside the house may be crucial in rural populations, while outdoor exercise and sunbathing may be more important in urban populations.
JOURNAL OF RURAL HEALTH
(2023)
Article
Public, Environmental & Occupational Health
Sarah E. Gollust, Erika Franklin Fowler, Rachel I. Vogel, Alexander J. Rothman, Marco Yzer, Rebekah H. Nagler
Summary: COVID-19 has exposed health inequity in the US, with disparities evident among racial and socioeconomic groups. However, public recognition of income- and race-based disparities remains low, influenced by political party affiliation.
PREVENTIVE MEDICINE
(2022)
Article
Oncology
Carlie A. Mell, Patricia Jewett, Deanna Teoh, Rachel Vogel, Susan A. Everson-Rose
Summary: This study aims to describe the fear of cancer recurrence among gynecologic cancer survivors and identify psychosocial factors that predict elevated fear. The findings reveal that fear of recurrence is prevalent among gynecologic cancer survivors. Higher levels of distress, hopelessness, anxiety, and surprisingly, post-traumatic growth are associated with greater fear. These results highlight the importance of addressing the psychosocial well-being of cancer survivors.
Article
Public, Environmental & Occupational Health
Lauren Thomaier, Danielle A. Aase, Rachel I. Vogel, Helen M. Parsons, Karim T. Sadak, Deanna Teoh
Summary: The objective of this study was to determine HPV vaccination coverage among individuals participating in a childhood cancer survivor program. The results showed that HPV vaccination initiation and completion of the 3-dose series are still suboptimal in a high-risk patient population.
PREVENTIVE MEDICINE REPORTS
(2022)
Article
Oncology
Andrew Etteldorf, Ramy Sedhom, Shannon M. M. Rotolo, Rachel I. I. Vogel, Christopher M. M. Booth, Anne H. H. Blaes, Beth A. A. Virnig, Stacie B. B. Dusetzina, Arjun Gupta
Summary: No single pharmacy consistently offers the lowest prices for medications in an urban zip code. Changes in medication prices across pharmacies pose challenges for patients and clinicians in accessing affordable medications. This is particularly relevant for cancer patients who require multiple fills of supportive care medications over time.
SUPPORTIVE CARE IN CANCER
(2023)
Article
Biochemistry & Molecular Biology
Jordan A. Naumann, Prokopios P. Argyris, Michael A. Carpenter, Harshita B. Gupta, Yanjun Chen, Nuri A. Temiz, Yufan Zhou, Cameron Durfee, Joshua Proehl, Brenda L. Koniar, Silvestro G. Conticello, David A. Largaespada, William L. Brown, Hideki Aihara, Rachel I. Vogel, Reuben S. Harris
Summary: Although well-known as antiviral factors, the APOBEC3 family of single-stranded DNA cytosine deaminases are also prominent sources of mutation in cancer, with its signature single-base substitutions evident in over 70% of human malignancies. Recent studies have shown that APOBEC3A and APOBEC3B can promote tumor formation in vivo. This research investigates the molecular mechanism of APOBEC3A-driven tumor development and demonstrates that APOBEC3A is a master driver that fuels tumor formation through a DNA deamination-dependent mechanism.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Rachel Isaksson Vogel, Xianghua Luo, Katherine Brown, Patricia Jewett, Allison C. Dona, Rebekah H. Nagler, Rehana L. Ahmed, Brian C. Martinson, DeAnn Lazovich
Summary: Wearing a device that measures and alerts melanoma survivors to UV radiation exposure did not result in significant changes in sun behaviors, exposure, or sunburns compared to controls.
Article
Public, Environmental & Occupational Health
Rebekah H. Nagler, Sarah E. Gollust, Marco C. Yzer, Rachel I. Vogel, Alexander J. Rothman
Summary: This study tested three different approaches to communicating about the scientific discovery process and found that providing these messages prior to exposure to conflicting health information can positively influence individuals' perceptions and knowledge of science, while reducing counterarguments.
SOCIAL SCIENCE & MEDICINE
(2023)
Article
Health Care Sciences & Services
Lindsey J. Wanberg, Angela Kim, Rachel Vogel, Karim Thomas Sadak, Deanna Teoh
Summary: This study developed a game-based learning app to educate and motivate young adults about cervical cancer screening. The app was found to be easy to use, moderately useful, and highly satisfying for participants.
JMIR FORMATIVE RESEARCH
(2023)
Article
Oncology
Alexandra Schefter, Lauren Thomaier, Patricia Jewett, Katherine Brown, Ashley E. Stenzel, Anne Blaes, Deanna Teoh, Rachel Vogel
Summary: This study found that sexual minority gynecologic cancer survivors reported poorer emotional health compared to heterosexual survivors, with higher rates of depression, anxiety, and PTSD. Additional resources and support may be needed for this population during and after cancer diagnosis to improve patient care and wellness.
