Review
Oncology
Susana Banerjee, Ronny Drapkin, Debra L. Richardson, Michael Birrer
Summary: This article discusses the research progress on NaPi2b as a novel biomarker for treatment and patient selection in ovarian cancer. NaPi2b is highly expressed in ovarian tumors and can be used for tumor mapping and therapeutic targeting. Clinical trial results have shown successful detection of NaPi2b in ovarian cancer patients, and it has the potential to elicit therapeutic responses.
CANCER TREATMENT REVIEWS
(2023)
Article
Biochemistry & Molecular Biology
Leisan Bulatova, Daria Savenkova, Alsina Nurgalieva, Daria Reshetnikova, Arina Timonina, Vera Skripova, Mikhail Bogdanov, Ramziya Kiyamova
Summary: This study presents the antibody mapping of untagged NaPi2b in live ovarian carcinoma cells, which provides valuable information for epitope-based cancer therapies and serological diagnostics.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Article
Medicine, Research & Experimental
Devivasha Bordoloi, Pratik S. Bhojnagarwala, Alfredo Perales-Puchalt, Abhijeet J. Kulkarni, Xizhou Zhu, Kevin Liaw, Ryan P. O'Connell, Daniel H. Park, Daniel W. Kulp, Rugang Zhang, David B. Weiner
Summary: Translation: Despite advances in ovarian cancer therapy, recurrent OC remains a poor-prognosis disease. Targeting the follicle-stimulating hormone receptor (FSHR) with monoclonal antibodies has shown potential for treating OC and other FSHR-positive cancers, and may overcome the challenge of off-target interactions.
Article
Biochemistry & Molecular Biology
Francesca Berni, Ermioni Kalfopoulou, Ana M. Gimeno Cardells, Filippo Carboni, Daan van der Es, Felipe Romero-Saavedra, Diana Laverde, Karmela Miklic, Suzana Malic, Tihana L. Rovis, Stipan Jonjic, Sara Ali, Herman S. Overkleeft, Cornelis H. Hokke, Angela van Diepen, Roberto Adamo, Jesus Jimenez-Barbero, Gijsbert A. van der Marel, Johannes Huebner, Jeroen D. C. Codee
Summary: This study developed and employed a monoclonal antibody against a synthetic TA for molecular-level binding analysis using TA microarrays, ELISA, SPR analyses, and STD-NMR spectroscopy. The findings showed that the number and chirality of GroP residues are crucial for interaction, and that the sugar appendage contributes to the presentation of the backbone to the binding site of the antibody.
ACS CHEMICAL BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Iason Psilopatis, Christos Damaskos, Anna Garmpi, Panagiotis Sarantis, Evangelos Koustas, Efstathios A. Antoniou, Dimitrios Dimitroulis, Gregory Kouraklis, Michail V. Karamouzis, Kleio Vrettou, Georgios Marinos, Konstantinos Kontzoglou, Nikolaos Garmpis
Summary: Unresectable hepatocellular carcinoma (HCC) is a poor-prognosis advanced primary liver malignancy. The FDA has approved several monoclonal antibodies (mAbs) including nivolumab, pembrolizumab, ramucirumab, nivolumab/ipilimumab, atezolizumab/bevacizumab, and tremelimumab/durvalumab as first- or second-line therapies for unresectable HCC. This review provides an update on the safety and efficacy of these mAbs, aiming to determine their suitability for different patient subgroups.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Immunology
Xiaojing Yang, Hanru Ren, Zhen Li, Xue Peng, Jie Fu
Summary: This article summarizes the application of immunotherapy in NPC, with a focus on the use of immunotherapy and radiotherapy in the treatment of NPC.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Yeon Jeong Kim, Fen Jiang, Jin Park, Hyeon Hee Jeong, Ji Eun Baek, Seung-Mo Hong, Seong-Yun Jeong, Sang Seok Koh
Summary: The study reveals the tumor-promoting role of PAUF in ovarian cancer and suggests that an anti-PAUF antibody may have therapeutic effects on high PAUF-expressing ovarian cancer.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Medicine, General & Internal
Rachel A. Bender Ignacio, Kara W. Chew, Carlee Moser, Judith S. Currier, Joseph J. Eron, Arzhang Cyrus Javan, Mark J. Giganti, Evgenia Aga, Michael Gibbs, Herve Tchouakam Kouekam, Eva Johnsson, Mark T. Esser, Keila Hoover, Gene Neytman, Matthew Newell, Eric S. Daar, William Fischer, Courtney V. Fletcher, Jonathan Z. Li, Alexander L. Greninger, Robert W. Coombs, Michael D. Hughes, Davey Smith, David Alain Wohl
Summary: These two clinical trials showed that tixagevimab and cilgavimab monoclonal antibodies were safe and effective for treating early COVID-19, but did not change the time to symptom improvement. The treatment outcomes were better for the intramuscular injection.
Article
Oncology
Cheng-Kai Wang, Tzu-Jou Chen, Grace Y. T. Tan, Fang -Pei Chang, Samyuktha Sridharan, Chen-Hsin Albert Yu, Yen-Hou Chang, Yi-Jen Chen, Li-Tzu Cheng, Wendy W. Hwang-Verslues
Summary: This study found that upregulation of MEX3A is critical for tumorigenesis in ovarian cancer cells expressing wild-type p53. MEX3A overexpression enhanced the growth and clonogenicity of OCCC cell lines, while MEX3A depletion reduced cell survival and proliferative ability. Additionally, MEX3A depletion inhibited tumor growth and prolonged survival in mouse models.
Article
Biochemistry & Molecular Biology
Xuyao Zhao, Gaojie Li, Zuoliang Sun, Yan Chen, Wenjun Guo, Yixian Li, Yimeng Chen, Jingjing Yang, Hongwei Hou
Summary: The study identified that the PHT family members are highly conserved in duckweeds, and SpPHTs are involved in the phosphate signaling pathway and interact with components of the dopamine signal pathway. Overexpression experiments and bioinformatics analysis revealed that PHT genes respond to external stimuli and are significantly induced under phosphate starvation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Multidisciplinary Sciences
Lisa Hiepp, Doris Mayr, Kathrin Gaertner, Elisa Schmoeckel, Frederick Klauschen, Alexander Burges, Sven Mahner, Reinhard Zeidler, Bastian Czogalla
Summary: Targeting the tumor-associated carbonic anhydrase XII (CA XII) is considered a promising strategy to improve cancer treatment. This study provides deeper information about the expression profile of CA XII in ovarian carcinomas, revealing significant expression in most tumor samples and ascites-derived cells. Higher levels of CA XII were found in ovarian carcinomas compared to borderline tumors and non-neoplastic ovarian epithelia. High expression of CA XII was associated with higher tumor grading and a trend towards shorter overall survival. The results suggest that CA XII plays a crucial role in the malignancy of ovarian carcinoma cells and has potential as a diagnostic marker and therapeutic target.
Article
Pharmacology & Pharmacy
Rachel A. Bender Ignacio, David A. Wohl, Rosalin Arends, Venkatesh Pilla Reddy, Ying Mu, Arzhang Cyrus Javan, Michael D. Hughes, Joseph J. Eron, Judith S. Currier, Davey Smith, Kara W. Chew, Michael Gibbs, Courtney Fletcher
Summary: This study evaluated the pharmacokinetics of AZD7442 in different administration routes and found that the thigh intramuscular injection had similar serum concentrations compared to intravenous injection in symptomatic adults with COVID-19. Thigh injection can provide consistent antibody exposure and improve convenience of use.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Biochemistry & Molecular Biology
Kumpanat Pomlok, Supansa Pata, Mattapong Kulaphisit, Rachan Pangnuchar, Jiraprapa Wipasa, Duncan R. Smith, Watchara Kasinrerk, Pathrapol Lithanatudom
Summary: This study investigates the use of anti-CD147 monoclonal antibodies (mAbs) targeting CD147 in hepatocellular carcinoma (HCC) cells and reveals the induction of acute cellular swelling, activation of unfolded protein response (UPR), autophagosome accumulation, and cell cycle arrest. Unlike classic apoptosis, prolonged treatment with these mAbs leads to irreversible cell death through a non-canonical necroptotic pathway. This study provides insights into targeting CD147 in HCC and sheds light on a novel strategy to induce necroptosis as a means of killing cancer cells.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2022)
Article
Immunology
Basudev Paudyal, Adam McNee, Pramila Rijal, B. Veronica Carr, Alejandro Nunez, John McCauley, Rodney S. Daniels, Alain R. Townsend, John A. Hammond, Elma Tchilian
Summary: Prophylactic intravenous administration of specific monoclonal antibodies in pigs showed significant reduction in lung pathology and virus loads, but not consistent reduction in nasal shedding. The effect on lung pathology and virus load is consistent across different doses, suggesting that lower doses may be effective in reducing disease severity.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Nanoscience & Nanotechnology
Ana Cepero, Cristina Luque, Laura Cabeza, Gloria Perazzoli, Francisco Quinonero, Cristina Mesas, Consolacion Melguizo, Jose Prados
Summary: The development of delivery systems based on nanomaterials, conjugated with monoclonal antibodies, shows promise in improving the efficiency and effectiveness of colorectal cancer therapy.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Article
Oncology
Gabriel Bandeira, Katia Rocha, Monize Lazar, Suzana Ezquina, Guilherme Yamamoto, Monica Varela, Vanessa Takahashi, Meire Aguena, Thomaz Gollop, Mayana Zatz, Maria Rita Passos-Bueno, Ana Krepischi, Oswaldo Keith Okamoto
Summary: This study evaluated the frequency of pathogenic/likely pathogenic germline variants in 105 Brazilian women with breast and/or ovarian cancer, identifying P/LP variants in 21% of patients and VUS variants in 14.3% of patients. A novel pathogenic ATM intragenic deletion was also discovered, along with a higher frequency of a BRCA1 pathogenic variant compared to other studies. These findings help characterize the genetic background of breast cancer predisposition in the Brazilian population.
Review
Cell & Tissue Engineering
Gabriella Shih Ping Hsia, Joyce Esposito, Leticia Alves da Rocha, Sofia Ligia Guimaraes Ramos, Oswaldo Keith Okamoto
Summary: Transplantation is crucial for individuals with end-stage organ failure diseases, but faces challenges such as organ rejection, donor shortage, and long waiting lines. With investments in laboratory-grown organs and advancements in organoid technology, regenerative medicine approaches hold promise for growing organs in vitro in the future.
STEM CELLS INTERNATIONAL
(2021)
Article
Oncology
Lucila N. Kerbauy, Nancy D. Marin, Mecit Kaplan, Pinaki P. Banerjee, Melissa M. Berrien-Elliott, Michelle Becker-Hapak, Rafet Basar, Mark Foster, Luciana Garcia Melo, Carly C. Neal, Ethan McClain, May Daher, Ana Karen Nunez Cortes, Sweta Desai, Francesca Wei Inng Lim, Mayela Carolina Mendt, Timothy Schappe, Li Li, Hila Shaim, Mayra Shanley, Emily L. Ensley, Nadima Uprety, Pamela Wong, Enli Liu, Sonny O. Ang, Rong Cai, Vandana Nandivada, Vakul Mohanty, Qi Miao, Yifei Shen, Natalia Baran, Natalie W. Fowlkes, Ken Chen, Luis Muniz-Feliciano, Richard E. Champlin, Yago L. Nieto, Joachim Koch, Martin Treder, Wolfgang Fischer, Oswaldo Keith Okamoto, Elizabeth J. Shpall, Todd A. Fehniger, Katayoun Rezvani
Summary: The study suggests that using bispecific engagers and cytokine pre-activation can enhance NK-cell cytotoxicity against NK-resistant cancers. Additionally, there are differences in treatment response based on the source of NK cells.
CLINICAL CANCER RESEARCH
(2021)
Meeting Abstract
Hematology
Heitor Duarte Andrade, Andrea Tiemi Kondo, Lucila Kerbauy, Raquel de Melo Alves Paiva, Denise Cristine Oliveira, Larissa Leggieri Coa, Kelen Cristina Arcuri Alvarez, Mariana Lorenzi Savioli, Bruna Melo Coelho Loureiro, Oswaldo Keith Okamoto, Nelson Hamerschlak, Jose Mauro Kutner, Juliana Aparecida Preto Godoy
Article
Cell Biology
Raquel M. Alves-Paiva, Sabrina do Nascimento, Denise De Oliveira, Larissa Coa, Kelen Alvarez, Nelson Hamerschlak, Oswaldo Keith Okamoto, Luciana C. Marti, Andrea T. Kondo, Jose Mauro Kutner, Maria Augusta Tezelli Bortolini, Rodrigo Castro, Juliana A. Preto de Godoy
Summary: This study reports a case where MSCs derived from an elderly donor entered a senescence state after three passages. MSCs cultured with AS displayed an early senescence state, and there were more senescence cells and altered gene expression compared to cells cultured with FBS.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Cell & Tissue Engineering
Maria Susana Joya Marodin, Juliana A. Godoy, Raquel M. Alves-Paiva, Kelen Alvarez, Thiago Giove Mitsugi, Ana Cristina Victorino Krepischi, Nelson Hamerschlak, Maria Augusta Tezelli Bortolini, Rodrigo Castro, Andrea T. Kondo, Jose Mauro Kutner, Oswaldo Keith Okamoto
Summary: Cytogenetic aberrations, such as trisomy 5, may occur in human mesenchymal stromal cells (MSC) during ex vivo expansion. It is still unclear how these aberrations affect the neoplastic transformation threshold or medicinal properties of MSC products. In this study, MSC cultures with clonal trisomy 5 showed reduced cell proliferation, increased senescence-associated beta-galactosidase activity, and poor tumor initiating capability. However, subcutaneous injection of these MSC populations did not generate tumors in immunodeficient mice within a six-month follow-up period. Importantly, MSC populations with clonal trisomy 5 maintained their immunomodulatory properties similar to euploid MSC upon interferon gamma (IFN gamma) licensing. These findings suggest that bone marrow MSC products with clonal trisomy 5 may still retain their therapeutic potential and support the definition of release criteria for autologous MSC products in critical clinical scenarios.
STEM CELLS INTERNATIONAL
(2022)
Meeting Abstract
Hematology
Lucila Kerbauy, Larissa Leggieri Coa, Micheli Severo Sielski, Juliana Aparecida Preto Godoy, Andrea Tiemi Kondo, Julia Teixeira Cottas Azevedo, Augusto Barbosa, Oswaldo Keith Okamoto, Jose Mauro Kutner, Nelson Hamerschlak, Raquel de Melo Alves Paiva
Meeting Abstract
Oncology
G. Bandeira, K. Rocha, M. Lazar, S. Ezquina, G. Yamamoto, T. Gollop, M. Zatz, M. Passos-Bueno, A. Krepischi, O. Keith Okamoto
EUROPEAN JOURNAL OF CANCER
(2022)
Meeting Abstract
Oncology
Matthew Sherwood, Carolini Kaid, Thiago Mitsugi, Yilu Zhou, Yihua Wang, Paul Skipp, Juliet Gray, Oswaldo Okamoto, Rob Ewing
Meeting Abstract
Oncology
Rodolfo Sanches Ferreira, Bruno H. S. Araujo, Oswaldo Okamoto
Article
Medicine, General & Internal
Alessandro Rozim Zorzi, Eliane Antonioli, Juliana Aparecida Preto de Godoy, Oswaldo Keith Okamoto, Andrea Tiemi Kondo, Jose Mauro Kutner, Camila Cohen Kaleka, Moises Cohen, Mario Ferretti
Summary: This article describes a case of autologous chondrocyte implantation that was contaminated by Mycoplasma pneumoniae during cell culture, and discusses the measures taken to successfully complete cell therapy.
EINSTEIN-SAO PAULO
(2022)
Meeting Abstract
Cell & Tissue Engineering
L. N. Kerbauy, L. Coa, A. T. Kondo, J. A. Godoy, I. Bello, O. K. Okamoto, J. M. Kutner, N. Hamerschlak, R. D. Alves Paiva
Meeting Abstract
Cell & Tissue Engineering
J. A. P. Godoy, R. M. A. Paiva, D. C. Oliveira, L. L. Coa, K. C. A. Alvarez, O. K. Okamoto, L. C. Marti, A. T. Kondo, M. A. T. Bortolini, R. Castro, J. M. Kutner
Meeting Abstract
Cell & Tissue Engineering
T. R. Santos, C. Kaid, D. D. Araujo, I. S. Neville, M. Uno, M. Zatz, O. K. Okamoto
Meeting Abstract
Cell & Tissue Engineering
J. A. Godoy, R. D. Alves Paiva, A. T. Kondo, L. N. Kerbauy, M. Rodrigues, O. K. Okamoto, J. M. Kutner