Article
Biology
Xinbo Qiao, Yixiao Zhang, Lisha Sun, Qingtian Ma, Jie Yang, Liping Ai, Jinqi Xue, Guanglei Chen, Hao Zhang, Ce Ji, Xi Gu, Haixin Lei, Yongliang Yang, Caigang Liu
Summary: The study found that a higher frequency of CD44(-)/CD24(-) breast cancer cells was associated with delayed breast cancer metastasis, and that RHBDL2 may play a role in breast cancer metastasis and CSC formation.
Article
Biochemistry & Molecular Biology
Olga Pershina, Natalia Ermakova, Angelina Pakhomova, Darius Widera, Edgar Pan, Mariia Zhukova, Elena Slonimskaya, Sergey G. Morozov, Aslan Kubatiev, Alexander Dygai, Evgenii G. Skurikhin
Summary: This study found that breast cancer patients can be divided into two groups based on the frequency of ALDH1 cells, corresponding to different types of stem cells. Additionally, epithelial precursors associated with a positive effect of chemotherapy and remission in breast cancer patients were found in normal breast tissue.
Review
Cell Biology
Gui-Min Wen, Xiao-Yan Xu, Pu Xia
Summary: The characteristics and molecular mechanisms of metabolic reprogramming of cancer stem cells play a crucial role in the treatment of malignant tumors.
Review
Multidisciplinary Sciences
Agus Rizal Ardy Hariandy Hamid, Yasmina Zahra Syadza, Oliver Emmanuel Yausep, Roberto Bagaskara Indy Christanto, Bayu Hernawan Rahmat Muharia, Chaidir Arif Mochtar
Summary: Bladder cancer is associated with high recurrence rates and metastasis. Cancer stem cells (CSCs) contribute to these processes and may serve as prognostic markers for bladder cancer. This study reviewed 12 clinical studies and identified multiple CSC markers that are implicated in the recurrence and metastasis of bladder cancer. The detection of these markers offers a promising approach to determine the prognosis of bladder cancer.
Article
Biochemistry & Molecular Biology
Pei-Yin Chen, Shih-Chi Chao, Pei-Ling Hsieh, Yi-Wen Liao, Pei-Ming Chu, Horng-Jyh Harn, Cheng-Chia Yu
Summary: Oral cancer is a common type of cancer worldwide, and targeting cancer stem cells (CSC) may lead to promising results in terms of tumor relapse and metastasis. This study found that butylidenephthalide, a compound from Angelica sinensis, has anti-CSC effects in oral cancer. It inhibited the proliferation, migration, invasion, and colony formation abilities of CSCs, and also delayed tumor development.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Genetics & Heredity
Eric Gyan, William K. B. A. Owiredu, Linda Ahenkorah Fondjo, Andrew M. Jackson, Andrew R. Green, Ganiyu A. Rahman
Summary: Breast cancer stem cells exhibit racial variations in expression patterns and clinical features, with CD44+/CD24-/low being associated with TNBC/Basal like phenotype across all races. ALDH1, the most studied breast CSC marker, is linked to poor clinicopathological features. Further research is needed to better understand the racial differences in breast cancer stem cells.
Review
Oncology
Mahdi Abdoli Shadbad, Negar Hosseinkhani, Zahra Asadzadeh, Afshin Derakhshani, Noora Karim Ahangar, Nima Hemmat, Parisa Lotfinejad, Oronzo Brunetti, Nicola Silvestris, Behzad Baradaran
Summary: CD44 and CD44(+)CD24(-/low) phenotype are associated with poor prognosis in TNBC patients, and these cancer stem cell markers are linked to advanced tumor stage, size, grade, metastasis, and lymphatic involvement in TNBC patients. Additionally, chemoradiotherapy-treated TNBC patients show an upregulation of CD44(+)CD24(-/low) phenotype, which inversely correlates with androgen receptor (AR) and leads to inferior prognosis.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Abdel-Rahman N. Zekri, Abeer Bahnassy, Magda Mourad, Ibrahim Malash, Ola Ahmed, Mona S. Abdellateif
Summary: This study characterized breast cancer stem cells (BCSCs) through genetic profiling, revealing specific molecular profiles that differ according to their phenotypes. These profiles could potentially impact patients' prognosis and outcome.
CANCER CELL INTERNATIONAL
(2022)
Review
Cell Biology
Alexander Ring, Maria Spataro, Andreas Wicki, Nicola Aceto
Summary: Progress in detection and treatment have significantly improved survival for early breast cancer patients, but distant recurrence remains a major challenge. Understanding the biology of disseminated tumor cells (DTCs) and dormancy in breast cancer has led to the identification of potential targeting strategies. Incorporating minimally invasive liquid biopsies and adjuvant therapies may help improve precision cancer care.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Multidisciplinary Sciences
Matias Blomqvist, Ilmari Koskinen, Eliisa Loyttyniemi, Tuomas Mirtti, Peter J. Bostrom, Pekka Taimen
Summary: In bladder cancer patients, the stem cell markers ALDH1, SOX2, and SSEA-4 show little prognostic or predictive value, with weak or negative cytoplasmic SOX2 staining being associated with lymphovascular invasion and cancer-specific survival but not significantly.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Kanakaraju Manupati, Ragini Yeeravalli, Komal Kaushik, Digvijay Singh, Bhupendra Mehra, Nitin Gangane, Anupama Gupta, Kalyan Goswami, Amitava Das
Summary: Breast cancer stem cells with high CD44 expression play a key role in tumorigenesis by activating PSTAT3, SNAI3, and LPL genes. Inhibiting CD44 or targeting LPL can effectively prevent tumor progression and neoangiogenesis.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2021)
Article
Biochemistry & Molecular Biology
Ruizhi Geng, Niklas Harland, Ivonne A. Montes-Mojarro, Falko Fend, Wilhelm K. Aicher, Arnulf Stenzl, Bastian Amend
Summary: In this study, it was found through experiments that the expression of CD24 in bladder cancer cell organoids may serve as an indicator for the prolonged proliferation potential of the cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Jing Li Huang, Masanori Oshi, Itaru Endo, Kazuaki Takabe
Summary: Clinically, patients with high CD24 expression in colorectal cancer tumors have better disease-specific and overall survival rates, and tumors with high CD133, CD24, and CD44 expression are associated with increased EGFR, KRAS, and Ki67 expression. Moreover, CD133-high/CD24-low tumors show potential for predicting worse prognosis in colorectal cancer patients.
AMERICAN JOURNAL OF CANCER RESEARCH
(2021)
Article
Cell Biology
Maxim Olsson, Peter Larsson, Junko Johansson, Vasu R. Sah, Toshima Z. Parris
Summary: This study revealed the enrichment of potentially treatment-resistant cancer stem cell subpopulations in the M and BL2 triple-negative breast cancer subtypes.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Pharmacology & Pharmacy
Caigang Liu, Yixiao Zhang, Jiujiao Gao, Qi Zhang, Lisha Sun, Qingtian Ma, Xinbo Qiao, Xinnan Li, Jinchi Liu, Jiawen Bu, Zhan Zhang, Ling Han, Dongyu Zhao, Yongliang Yang
Summary: This study reports the discovery and biological evaluation of a highly potent small-molecule antagonist, LFS-1107, targeting breast cancer stem-like cells (BCSCs) in triple-negative breast cancer (TNBC). LFS-1107 selectively eliminates CD44(+)CD24(-) enriched BCSCs and shows significant inhibitory effects on TNBC tumor cells. These findings provide preclinical evidence that LFS-1107 could be a promising therapeutic agent for the treatment of TNBC.
DRUG RESISTANCE UPDATES
(2023)
Article
Obstetrics & Gynecology
Giorgio Bogani, Antonino Ditto, Loris De Cecco, Salvatore Lopez, Rocco Guerrisi, Federico Piccioni, Arianna Micali, Maria Grazia Daidone, Francesco Raspagliesi
Summary: This study aimed to investigate the presence of SARS-CoV-2 in surgical smoke and found a presumptive positive case, suggesting the potential transmission of SARS-CoV-2 through surgical smoke.
JOURNAL OF MINIMALLY INVASIVE GYNECOLOGY
(2021)
Article
Oncology
Roos F. Bleckman, Ibtissam Acem, Veroniek M. van Praag, Desiree M. J. Dorleijn, Cornelis Verhoef, Yvonne M. Schrage, Rick M. L. Haas, Michiel A. J. van de Sande
Summary: This study revealed that elderly patients with eUPS are less likely to receive radiotherapy and have a higher local recurrence rate, suggesting the consideration of multimodality treatment.
Article
Oncology
Sara Pizzamiglio, Giulia Cosentino, Chiara M. Ciniselli, Loris De Cecco, Alessandra Cataldo, Ilaria Plantamura, Tiziana Triulzi, Sarra El-abed, Yingbo Wang, Mohammed Bajji, Paolo Nuciforo, Jens Huober, Susan L. Ellard, David L. Rimm, Andrea Gombos, Maria Grazia Daidone, Paolo Verderio, Elda Tagliabue, Serena Di Cosimo, Marilena V. Iorio
Summary: The study evaluated the predictive and prognostic value of basal primary tumor miRNA expression profile in trastuzumab treatment and identified miRNA signatures associated with clinical outcomes. These miRNA markers have the potential to be a useful tool in identifying patients with differential responses to trastuzumab-based neoadjuvant therapy.
Meeting Abstract
Oncology
S. Di Cosimo, C. M. Ciniselli, C. Sotiriou, K. Pogue-Geile, D. Fumagalli, E. de Azambuja, D. Venet, L. De Cecco, N. Pong, V. Cappelletti, E. Tagliabue, Y. Wang, C. Saura Manich, P. G. Nuciforo, S. Kuemmel, L. Pusztai, M. G. Daidone, S. Pizzamiglio, G. Pruneri, P. Verderio
ANNALS OF ONCOLOGY
(2022)
Meeting Abstract
Oncology
Francesca Ligorio, Serena Di Cosimo, Paolo Verderio, Chiara Maura Ciniselli, Sara Pizzamiglio, Lorenzo Castagnoli, Tiziana Triulzi, Elda Tagliabue, Sarra El-Abed, Miguel Izquierdo, Evandro de Azambuja, Paolo Nuciforo, Jens Huober, Luca Moscetti, Wolfgang Janni, M. Coccia-Portugal, Paola Corsetto, Antonino Belfiore, Daniele Lorenzini, Maria Grazia Daidone, Andrea VIngiani, Serenella M. Pupa, Giancarlo Pruneri, Claudio Vernieri
Article
Oncology
Ibtissam Acem, Winan J. van Houdt, Dirk J. Grunhagen, Winette T. A. van der Graaf, Anja J. Rueten-Budde, Hans Gelderblom, Cornelis Verhoef, Michiel A. J. van de Sande
Summary: This study aimed to assess the effect of perioperative chemo-therapy (CTX) on overall survival (OS) in patients with extremity soft tissue sarcoma (eSTS) and evaluate the predictive value of the PERSARC tool. The results showed that AI-based CTX was significantly associated with improved 5-year OS in high-risk patients, but no beneficial effect of CTX on OS was found in the overall population of patients with primary high-grade eSTS younger than 70 years.
EUROPEAN JOURNAL OF CANCER
(2022)
Article
Oncology
E. La Rocca, M. C. De Santis, M. Silvestri, E. Ortolan, M. Valenti, S. Folli, F. G. de Braud, G. Bianchi, G. P. Scaperrotta, G. Apolone, M. G. Daidone, V Cappelletti, G. Pruneri, S. Di Cosimo
Summary: This study analyzed the current practices and the use of circulating tumor DNA (ctDNA) in monitoring high-risk breast cancer patients. The results showed that some recurrences were still symptomatic, but ctDNA is a specific test that is sensitive enough to detect recurrence before other methods.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2022)
Article
Oncology
Emanuela Fina, Loredana Cleris, Matteo Dugo, Mara Lecchi, Chiara Maura Ciniselli, Daniele Lecis, Giulia Valeria Bianchi, Paolo Verderio, Maria Grazia Daidone, Vera Cappelletti
Summary: The study highlights the importance of understanding the hematogenous phase of breast cancer metastasis and identifies genes associated with metastasis through transcriptome analysis of circulating tumor cells. These findings provide valuable information on disease progression and potential therapeutic targets.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2022)
Article
Oncology
Dominik A. Barth, Stefanie Stanzer, Jasmin Spiegelberg, Thomas Bauernhofer, Gudrun Absenger, Florian Posch, Rainer Lipp, Michael Halm, Joanna Szkandera, Marija Balic, Armin Gerger, Maria A. Smolle, Georg C. Hutterer, Christiane Klec, Philipp J. Jost, Julia Kargl, Martin Stradner, Martin Pichler
Summary: This prospective study aimed to evaluate the association between autoantibodies in the serum of cancer patients and immune-checkpoint inhibitor (ICI) therapy response and immune-related adverse events (irAEs). The results showed that there was no significant association between the presence of autoantibodies and treatment efficacy or higher grade irAEs, neither at treatment start nor after 8-12 weeks of ICI treatment.
Review
Immunology
Chiara Maura Ciniselli, Mara Lecchi, Mariangela Figini, Cecilia C. Melani, Maria Grazia Daidone, Daniele Morelli, Emanuela Zito, Giovanni Apolone, Paolo Verderio
Summary: Despite the global public health emergency of the COVID-19 pandemic, studies show that healthcare workers in Italy exhibit a robust antibody response after receiving the second vaccine dose. In a longitudinal study, 99.81% of HCWs developed an antibody response one month after the second dose, and six months later, all HCWs still showed positivity to antibodies, although at lower levels. The literature review and institutional study both confirm a strong antibody response in HCWs even seven months after completing the cycle of vaccination doses.
Article
Oncology
Francesca Ligorio, Serena Di Cosimo, Paolo Verderio, Chiara Maura Ciniselli, Sara Pizzamiglio, Lorenzo Castagnoli, Matteo Dugo, Barbara Galbardi, Roberto Salgado, Sherene Loi, Stefan Michiels, Tiziana Triulzi, Elda Tagliabue, Sarra El-Abed, Miguel Izquierdo, Evandro de Azambuja, Paolo Nuciforo, Jens Huober, Luca Moscetti, Wolfgang Janni, Maria Antonia Coccia-Portugal, Paola Antonia Corsetto, Antonino Belfiore, Daniele Lorenzini, Maria Grazia Daidone, Andrea Vingiani, Luca Gianni, Serenella Maria Pupa, Giampaolo Bianchini, Giancarlo Pruneri, Claudio Vernieri
Summary: This study found that high expression of CD36 is associated with worse clinical outcomes in early-stage HER2+ BC patients treated with anti-HER2 therapy.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
(2022)
Article
Oncology
Joanna Szkandera
Summary: This case study explores the journey of a patient with nonuterine leiomyosarcoma, highlighting the effectiveness of trabectedin in maintaining disease control and functional performance.
Letter
Surgery
Armando G. Licata, Chiara M. Ciniselli, Luca Sorrentino, Arianna Micali, Maria Grazia Daidone, Marcello Guaglio, Manuela Gariboldi, Paolo Verderio, Loris De Cecco, Maurizio Cosimelli
BRITISH JOURNAL OF SURGERY
(2023)
Meeting Abstract
Oncology
S. Pizzamiglio, C. M. Ciniselli, E. De Azambuja, D. Agbor-Tarh, A. Moreno-Aspitia, T. Suter, A. Trama, M. G. Daidone, P. Verderio, S. Di Cosimo
EUROPEAN JOURNAL OF CANCER
(2022)
Article
Oncology
Monica Niger, Federico Nichetti, Francesca Dell'Angelo, Vera Cappelletti, Chiara Pircher, Marta Vismara, Christian Cotsoglou, Sherrie Bhoori, Andrea Vingiani, Maria Di Bartolomeo, Filippo Pietrantonio, Filippo de Braud, Giancarlo Pruneri, Maria Grazia Daidone, Vincenzo Mazzaferro
JCO PRECISION ONCOLOGY
(2022)