Article
Microbiology
Abbas Karimi, Elham Mohebbi, Sandrine Mckay-Chopin, Hamideh Rashidian, Maryam Hadji, Vahideh Peyghambari, Maryam Marzban, Ahmad Naghibzadeh-Tahami, Mahin Gholipour, Farin Kamangar, Massimo Tommasino, Tarik Gheit, Kazem Zendehdel
Summary: This study analyzed the detection of alpha-, beta-, and gamma-HPVs in oral rinse samples of HNSCC cases and controls in Iran, finding that the contribution of alpha-HPVs to HNSCC in Iran is lower than global prevalence, and high-risk alpha-HPVs or cutaneous beta- and gamma-HPVs were not associated with HNSCC development.
MICROBIOLOGY SPECTRUM
(2022)
Review
Biochemistry & Molecular Biology
Xin Zhou, Xiaoshen Wang
Summary: This review provides a detailed illustration of the biology, genomic features, and immune landscapes of HPV-associated HNSCC, supporting the synergistic effect of radioimmunotherapy. Current evidence and ongoing clinical trials suggest the potential of radioimmunotherapy in recurrent/metastatic or definitive settings. Future challenges include optimization of radiotherapy and the incorporation of novel therapeutic options.
Article
Oncology
Jaylou M. Velez Torres, Turky Alkathery, Youley Tjendra, Yiqin Zuo, Darcy A. Kerr, Carmen Gomez-Fernandez
Summary: This study evaluated the utility of HR-HPV ISH in metastatic head and neck squamous cell carcinoma (SCC). The results showed that HR-HPV ISH can be reliably performed on smears or LBC preparations, particularly when cell blocks are unavailable or paucicellular.
CANCER CYTOPATHOLOGY
(2023)
Article
Oncology
Masato Mima, Atsushi Okabe, Takayuki Hoshii, Takuya Nakagawa, Tomoya Kurokawa, Satoru Kondo, Harue Mizokami, Masaki Fukuyo, Ryoji Fujiki, Bahityar Rahmutulla, Tomokazu Yoshizaki, Toyoyuki Hanazawa, Kiyoshi Misawa, Atsushi Kaneda
Summary: Human papillomavirus (HPV) plays a causal role in the development of head and neck squamous cell carcinoma (HNSCC) by integrating into the host genome and causing genomic alterations. This study analyzed the epigenome, transcriptome, and interactome of HPV-positive HNSCCs to understand the role of epigenetic dysregulation in tumorigenesis. The results showed that genes neighboring HPV integration sites were upregulated and correlated with oncogenic phenotypes in HPV-positive HNSCCs. The epigenetic activation of HPV-interacting regions (HPVIRs) contributed to the genesis of HPV-positive HNSCC.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Pathology
Nina Gale, Mario Poljak, Metka Volavsek, Lea Hosnjak, Dane Velkavrh, Luka Bolha, Kristina Fujs Komlos, Primoz Strojan, Aleksandar Anicin, Nina Zidar
Summary: The study evaluated the transcriptional activity of high-risk HPV in oropharyngeal squamous cell carcinomas and found that HPV positivity is significant for predicting patient survival.
PATHOLOGY RESEARCH AND PRACTICE
(2021)
Article
Immunology
Yourong Jiang, Siwei Zhang, Lu Tang, Rui Li, Jinglei Zhai, Suisui Luo, Yiman Peng, Xiaohang Chen, Lanlan Wei
Summary: This study constructed a single-cell atlas of macrophages from HPV-negative and HPV-positive HNSCC patients using single-cell RNA sequencing data. The results showed that macrophages in HPV-positive HNSCC exhibit stronger phagocytic ability, while TCR+ macrophages play a critical role in the HNSCC microenvironment.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biology
Delphine Avril, Jean-Philippe Foy, Jebrane Bouaoud, Vincent Gregoire, Pierre Saintigny
Summary: This article aims to review recently proposed biomarkers of radioresistance in HPV-negative HNSCC, which can be useful for stratifying tumor patients based on their predicted level of radioresistance.
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY
(2023)
Article
Oncology
Mark D. Wilkie, Emad A. Anaam, Andrew S. Lau, Carlos P. Rubbi, Nikolina Vlatkovic, Terence M. Jones, Mark T. Boyd
Summary: This study investigated the metabolic profile and potential role of anti-metabolic therapeutics in radiosensitization of HPV-positive SCCHN. Results showed that these cells have a diverse metabolic phenotype and require a complex anti-metabolic approach to sensitize them to radiation. This finding may offer a platform for treatment de-intensification in clinical settings by reducing radiation doses.
Review
Immunology
Huanhuan Wang, Qin Zhao, Yuyu Zhang, Qihe Zhang, Zhuangzhuang Zheng, Shiyu Liu, Zijing Liu, Lingbin Meng, Ying Xin, Xin Jiang
Summary: Head and neck cancer, primarily head and neck squamous cell carcinoma, is commonly treated with surgery, radiotherapy, chemotherapy, and immunotherapy. Immunotherapy, particularly for HPV-positive patients, has shown promising results possibly due to higher immune cell infiltration and differential expression of immune checkpoints in tumors. Personalized immunotherapy trials are also being conducted in HPV-positive patients.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Oncology
Kayla R. Getz, Emily Bellile, Katie R. Zarins, Cailey Rullman, Steven B. Chinn, Jeremy M. G. Taylor, Laura S. Rozek, Gregory T. Wolf, Alison M. Mondul
Summary: The study identified a significant inverse association between statin use and overall death, disease-specific death, and recurrence in untreated HNSCC patients. This protective effect was particularly pronounced in patients with HPV-positive disease.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Oncology
Ping Zhou, Yi-Feng Yu, Chen-Lu Lian, Jun Wang, Ren-Gong Zhuo, San-Gang Wu
Summary: HPV-positive HNSCC patients have better survival outcomes and HPV-negative status, N3 stage, bone metastases, and lung metastases are associated with worse outcomes. Determination of HPV status may guide clinicians in treatment decisions for stage IV HNSCC patients.
FRONTIERS IN ONCOLOGY
(2021)
Review
Oncology
Yihong Hu, Yucheng Han, Minhui He, Yanqun Zhang, Xianqiong Zou
Summary: Head and neck squamous cell carcinoma (HNSCC) is the most common tumor affecting the head and neck, characterized by rapid onset, lack of early diagnosis, drug resistance, relapse, and systemic adverse effects. S100 proteins have been associated with HNSCC, including S100A8, S100A9, and S100A14, which inhibit tumor cell proliferation. S100A4 enhances cancer stem cell properties and promotes tumor cell migration. Several signaling pathways, such as Hippo, nuclear factor κB, and phosphatidylinositol kinase/protein kinase B/mammalian target of rapamycin, involve S100 proteins in the initiation and progression of HNSCC. Long non-coding RNAs and microRNAs also play a role in regulating the expression of S100 proteins in HNSCC. Reducing the expression of certain S100 proteins may improve the chemosensitivity of HNSCC. Therefore, S100 proteins could serve as markers and targets for the prevention, diagnosis, and treatment of HNSCC.
Review
Biochemistry & Molecular Biology
Sindhu Nair, James A. Bonner, Markus Bredel
Summary: EGFR is overexpressed in head and neck squamous cell carcinoma and anti-EGFR strategies have shown some clinical benefit but often lead to resistance. Mutations in various domains of the EGFR gene can impact drug binding, radiation response, and overall survival in HNSCC patients. Understanding the EGFR mutational landscape and its effects on treatment resistance can help stratify patients for targeted therapies and maximize therapeutic benefits.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biology
Danni Cheng, Ke Qiu, Yufang Rao, Minzi Mao, Li Li, Yan Wang, Yao Song, Junren Chen, Xiaowei Yi, Xiuli Shao, Shao Hui Huang, Yi Zhang, Xuemei Chen, Sisi Wu, Shuaishuai Yu, Jun Liu, Haiyang Wang, Xingchen Peng, Daibo Li, Lin Yang, Li Chen, Zhiye Ying, Yongbo Zheng, Meijun Zheng, Binwu Ying, Xiaoxi Zeng, Wei Zhang, Wei Xu, Geoffrey Liu, Fei Chen, Haopeng Yu, Yu Zhao, Jianjun Ren
Summary: By using multi-omics sequencing, a proliferative exhausted CD8(+) T cells cluster (P-Tex) that is beneficial to the survival outcomes of patients with HPV-positive HNSCC was identified. P-Tex cells aggregate in the antigen-presenting cell niches and activate certain signaling pathways, providing modest but persistent anti-tumor effects.
Review
Immunology
Habib Sadeghi Rad, Yavar Shiravand, Payar Radfar, Rahul Ladwa, Chris Perry, Xiaoyuan Han, Majid Ebrahimi Warkiani, Mark N. Adams, Brett G. M. Hughes, Ken O'Byrne, Arutha Kulasinghe
Summary: This review discusses the characteristics of Head and Neck Squamous Cell Carcinoma (HNSCC), predictive biomarkers, and factors influencing the response to immunotherapy, with a focus on the tumor microenvironment.
CLINICAL & TRANSLATIONAL IMMUNOLOGY
(2022)