Cellular evidence for selfish spermatogonial selection in aged human testes

Detection of Clinically Relevant Genetic Variants in Autism Spectrum Disorder by Whole-Genome Sequencing

(2013) Yong-hui Jiang et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Age-Dependent Germline Mosaicism of the Most Common Noonan Syndrome Mutation Shows the Signature of Germline Selection

(2013) Song-Ro Yoon et al.   AMERICAN JOURNAL OF HUMAN GENETICS

“Selfish Spermatogonial Selection”: A Novel Mechanism for the Association Between Advanced Paternal Age and Neurodevelopmental Disorders

(2013) Anne Goriely et al.   AMERICAN JOURNAL OF PSYCHIATRY

Novel Stage Classification of Human Spermatogenesis Based on Acrosome Development1

(2013) Barbara Muciaccia et al.   BIOLOGY OF REPRODUCTION

Paternal aging and associated intraindividual alterations of global sperm 5-methylcytosine and 5-hydroxymethylcytosine levels

(2013) Timothy G. Jenkins et al.   FERTILITY AND STERILITY

New evidence for positive selection helps explain the paternal age effect observed in achondroplasia

(2013) Deepali N. Shinde et al.   HUMAN MOLECULAR GENETICS

PIK3CA-AKT pathway mutations in micropapillary breast carcinoma

(2013) Ellen Flatley et al.   HUMAN PATHOLOGY

Expression of FGFR3 during human testis development and in germ cell-derived tumours of young adults

(2013) Katherine A. Ewen et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY

Ageing of the male germ line

(2013) Catriona Paul et al.   Nature Reviews Urology

Contributions of intrinsic mutation rate and selfish selection to levels of de novo HRAS mutations in the paternal germline

(2013) E. Giannoulatou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MEK/ERK signaling directly and indirectly contributes to the cyclical self-renewal of spermatogonial stem cells

(2013) Kazuteru Hasegawa et al.   STEM CELLS

Paternal Age Effect Mutations and Selfish Spermatogonial Selection: Causes and Consequences for Human Disease

(2012) Anne Goriely et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Somatic Mosaic Activating Mutations in PIK3CA Cause CLOVES Syndrome

(2012) Kyle C. Kurek et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Germline PIK3CA and AKT1 Mutations in Cowden and Cowden-like Syndromes

(2012) Mohammed S. Orloff et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Whole-Genome Sequencing in Autism Identifies Hot Spots for De Novo Germline Mutation

(2012) Jacob J. Michaelson et al.   CELL

FGF2 mediates mouse spermatogonial stem cell self-renewal via upregulation of Etv5 and Bcl6b through MAP2K1 activation

(2012) K. Ishii et al.   DEVELOPMENT

A matter of life and death: self-renewal in stem cells

(2012) Elaine Fuchs et al.   EMBO REPORTS

Fibroblast growth factor receptor 3 is highly expressed in rarely dividing human type A spermatogonia

(2012) Kathrein Kopylow et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Somatic gain-of-function mutations in PIK3CA in patients with macrodactyly

(2012) Jonathan J. Rios et al.   HUMAN MOLECULAR GENETICS

Divergence of sperm and leukocyte age-dependent telomere dynamics: implications for male-driven evolution of telomere length in humans

(2012) K. I. Aston et al.   MOLECULAR HUMAN REPRODUCTION

Rate of de novo mutations and the importance of father’s age to disease risk

(2012) Augustine Kong et al.   NATURE

De novo germline and postzygotic mutations in AKT3, PIK3R2 and PIK3CA cause a spectrum of related megalencephaly syndromes

(2012) Jean-Baptiste Rivière et al.   NATURE GENETICS

De novo somatic mutations in components of the PI3K-AKT3-mTOR pathway cause hemimegalencephaly

(2012) Jeong Ho Lee et al.   NATURE GENETICS

Selfish Spermatogonial Selection: Evidence from an Immunohistochemical Screen in Testes of Elderly Men

(2012) Jasmine Lim et al.   PLoS One

Positive Selection for New Disease Mutations in the Human Germline: Evidence from the Heritable Cancer Syndrome Multiple Endocrine Neoplasia Type 2B

(2012) Soo-Kyung Choi et al.   PLoS Genetics

OCT2, SSX and SAGE1 reveal the phenotypic heterogeneity of spermatocytic seminoma reflecting distinct subpopulations of spermatogonia

(2011) Jasmine Lim et al.   JOURNAL OF PATHOLOGY

Differential marker protein expression specifies rarefaction zone-containing human Adark spermatogonia

(2011) Kathrein von Kopylow et al.   REPRODUCTION

Advanced paternal and grandpaternal age and schizophrenia: A three-generation perspective

(2011) Emma M. Frans et al.   SCHIZOPHRENIA RESEARCH

On the Morphology of the Transitional Zone of the Seminiferous Tubule and the Rete Testis in Man

(2010) S.G. LINDNER et al.   ANDROLOGIA

FGFR3 signaling induces a reversible senescence phenotype in chondrocytes similar to oncogene-induced premature senescence

(2010) Pavel Krejci et al.   BONE

PIK3CA Mutations in In situ and Invasive Breast Carcinomas

(2010) A. Miron et al.   CANCER RESEARCH

Mouse Germ Line Stem Cells Undergo Rapid and Stochastic Turnover

(2010) Allon M. Klein et al.   Cell Stem Cell

Accumulation of driver and passenger mutations during tumor progression

(2010) I. Bozic et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Risk of Autism and Increasing Maternal and Paternal Age in a Large North American Population

(2009) J. K. Grether et al.   AMERICAN JOURNAL OF EPIDEMIOLOGY

Isolation, Characterization, and Culture of Human Spermatogonia1

(2009) Zuping He et al.   BIOLOGY OF REPRODUCTION

Spermatogonial stem cells: Mouse and human comparisons

(2009) Martin Dym et al.   BIRTH DEFECTS RESEARCH PART C-EMBRYO TODAY-REVIEWS

Analysis of Gene Expression Profiles of Microdissected Cell Populations Indicates that Testicular Carcinoma In situ Is an Arrested Gonocyte

(2009) S. B. Sonne et al.   CANCER RESEARCH

Genetic Reconstruction of Mouse Spermatogonial Stem Cell Self-Renewal In Vitro by Ras-Cyclin D2 Activation

(2009) Jiyoung Lee et al.   Cell Stem Cell

The role of senescence and prosurvival signaling in controlling the oncogenic activity of FGFR2 mutants associated with cancer and birth defects

(2009) Sara Ota et al.   HUMAN MOLECULAR GENETICS

Activating mutations in FGFR3 and HRAS reveal a shared genetic origin for congenital disorders and testicular tumors

(2009) Anne Goriely et al.   NATURE GENETICS

Stochastic fate of p53-mutant epidermal progenitor cells is tilted toward proliferation by UV B during preneoplasia

(2009) A. M. Klein et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Ups and Downs of Mutation Frequencies during Aging Can Account for the Apert Syndrome Paternal Age Effect

(2009) Song-Ro Yoon et al.   PLoS Genetics

Offspring's Leukocyte Telomere Length, Paternal Age, and Telomere Elongation in Sperm

(2008) Masayuki Kimura et al.   PLoS Genetics

A germ-line-selective advantage rather than an increased mutation rate can explain some unexpectedly common human disease mutations

(2008) S.-K. Choi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Gdnf Upregulates c-Fos Transcription via the Ras/Erk1/2 Pathway to Promote Mouse Spermatogonial Stem Cell Proliferation

(2007) Zuping He et al.   STEM CELLS