Article
Dermatology
Patricia M. Richey, Leah Laageide, Brian L. Swick
Summary: This study found that patients with psychocutaneous disorders have high rates of stimulant use and comorbidity with psychiatric disorders. The findings are important for understanding the etiology and treatment of psychocutaneous disorders.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Eriko Toyoda, Miki Maehara, Masahiko Watanabe, Masato Sato
Summary: Osteoarthritis (OA) of the knee is a disease that significantly decreases the quality of life due to joint deformation and pain caused by degeneration of articular cartilage. Intervening from an early stage and controlling throughout life is important for OA treatment, and there is a focus on developing a new treatment approach.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Immunology
Wing Sum Chu, Joanne Ng
Summary: rAAV gene therapy has shown promise but faces challenges due to immune responses, solutions involving immunosuppression or modulation are being explored to overcome these issues.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medicine, Legal
Maaz Z. Siddiqui, John P. Piserchio, Misha Patel, Jino Park, Michelle L. Foster, Clare E. Desrosiers, John Herbert, Stephanie D. Nichols, Kenneth L. McCall, Brian J. Piper
Summary: The study aims to identify the drugs involved in polysubstance arrests. The results show that opioids are the most commonly involved drug in both single and multiple drug arrests. The misuse potential of certain commonly prescribed drugs is underestimated and requires more attention.
FORENSIC SCIENCE MEDICINE AND PATHOLOGY
(2022)
Review
Psychiatry
Mai Thi Ngoc Tran, Quang Hung Luong, Giang Le Minh, Michael P. Dunne, Philip Baker
Summary: This overview of systematic reviews found that compared to usual care, patients in psychosocial intervention groups showed reduced drug usage and injectable drug use, lower risk of unsafe sex, and improved treatment adherence. Cognitive behavioural therapy was less likely to retain patients at follow-up, but the addition of contingency management strategy significantly improved retention rates.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Oncology
Dongdong Zhan, Nairen Zheng, Beibei Zhao, Fang Cheng, Qi Tang, Xiangqian Liu, Juanfei Wang, Yushen Wang, Haibo Liu, Xinliang Li, Juming Su, Xuejun Zhong, Qing Bu, Yating Cheng, Yi Wang, Jun Qin
Summary: NGS and proteomics tests identified actionable mutated genes and clinical drug targets in cancer samples, providing treatment options for a significant number of patients. Protein overexpression, such as Map2k1, could be a potential indicator for guiding targeted therapies. Combining NGS and proteomics could expand targeted treatment options to 85% of cancer patients.
Article
Pharmacology & Pharmacy
Ian M. Henderson, Fanxun Zeng, Nazmul H. Bhuiyan, Dan Luo, Maria Martinez, Jane Smoake, Fangchao Bi, Chamani Perera, David Johnson, Thomas E. Prisinzano, Wei Wang, George R. Uhl
Summary: This study reports a novel candidate PTPRD phosphatase inhibitor with high potency and selectivity. The compound showed good oral bioavailability and tolerance in in vivo studies, suggesting its potential role in reducing reward from addictive substances.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Leisheng Shi, Yan Wang, Chong Li, Kunlin Zhang, Quansheng Du, Mei Zhao
Summary: AddictGene is a resource that integrates multidimensional data related to commonly abused substances, including gene expression, gene-gene interaction, gene-drug interaction, and epigenetic regulatory information. This database provides detailed information about differentially expressed genes, offering a valuable resource for studying the molecular mechanisms underlying addiction.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2021)
Article
Rheumatology
Marta Novella-Navarro, Joseluis Cabrera-Alarcon, Natalia Lopez-Juanes, Alejandro Villalba, Elisa Fernandez Fernandez, Irene Monjo, Diana Peiteado, Laura Nuno, Chamaida Plasencia-Rodriguez, Alejandro Balsa
Summary: The study aims to analyze the trajectories of DAS28, PGA, and PhGA and assess their predictive capabilities for D2TRA classification.
Article
Chemistry, Multidisciplinary
Soon Gil Jeong, Yeong Chae Ryu, Byeong Hee Hwang
Summary: The novel synergistic nanocomplexes designed in this study efficiently transfected cells, improved gene expression, and showed good biocompatibility. This new strategy provides an efficient and safe gene carrier for treating various genetic diseases.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Microbiology
John S. Bradley, Jennifer L. Goldman, Laura P. James, Byron Kaelin, Breanne H. Y. Gibson, Antonio Arrieta
Summary: This study aimed to evaluate the safety and pharmacokinetics of telavancin in pediatric patients. The results showed that telavancin was well-tolerated in all age groups, with increased clearance and reduced exposure compared to adults.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2023)
Review
Pharmacology & Pharmacy
Lianxiao Liu, Yiming Zhou, Anqiu Xu, Chenglong Wang, Ning Li, Hongwei Huang, Yuntao Zhang, Xiaoming Yang
Summary: Nucleic acid drugs are effective in treating genetic diseases. This review focuses on the mechanism and various types of non-viral vectors used for delivering nucleic acid drugs, including conjugates, nanoparticles based on proteins and peptides, polysaccharides, and other biological macromolecules. The challenges and prospects of using non-viral vectors for nucleic acid drug delivery are also discussed.
ADVANCED THERAPEUTICS
(2023)
Review
Biochemistry & Molecular Biology
Xin Zhao, Suryaji Patil, Fang Xu, Xiao Lin, Airong Qian
Summary: The article focuses on the importance of osteoclasts in bone metabolism and their relationship with osteoporosis, while also introducing some drug therapies targeting these molecules.
Editorial Material
Multidisciplinary Sciences
Sara Reardon
Summary: The FDA's decision, which is expected to be announced this month, has been delayed multiple times, causing difficulties for families of children with Duchenne muscular dystrophy.
Review
Pharmacology & Pharmacy
Ekram Ahmed Chowdhury, Guy Meno-Tetang, Hsueh Yuan Chang, Shengjia Wu, Hsien Wei Huang, Tanguy Jamier, Jayanth Chandran, Dhaval K. Shah
Summary: Protein therapeutics are successful but expensive and not suitable for long-term treatment. AAV-mediated gene therapy offers an alternative, but there is limited understanding of its key properties.
ADVANCED DRUG DELIVERY REVIEWS
(2021)
Article
Biochemistry & Molecular Biology
Ruiling Zhang, Qin Miao, Chuansheng Wang, Rongrong Zhao, Wenqiang Li, Colin N. Haile, Wei Hao, Xiang Yang Zhang
Article
Psychology, Clinical
Jin H. Yoon, Thomas F. Newton, Colin N. Haile, Patrick S. Bordnick, Rachel E. Fintzy, Chris Culbertson, James J. Mahoney, Rollin Y. Hawkins, Kathleen R. LaBounty, Elizabeth L. Ross, Adel I. Aziziyeh, Richard De La Garza
ADDICTIVE BEHAVIORS
(2013)
Article
Neurosciences
Xiang Yang Zhang, Wu-Fang Zhang, Dong-Feng Zhou, Da Chun Chen, Mei Hong Xiu, Hao-Ran Wu, Colin N. Haile, Therese A. Kosten, Thomas R. Kosten
BIOLOGICAL PSYCHIATRY
(2012)
Article
Substance Abuse
Colin N. Haile, Richard De La Garza, James J. Mahoney, Thomas F. Newton
DRUG AND ALCOHOL DEPENDENCE
(2013)
Article
Substance Abuse
Christopher D. Verrico, Colin N. Haile, James J. Mahoney, Daisy G. Y. Thompson-Lake, Thomas F. Newton, Richard De La Garza
DRUG AND ALCOHOL DEPENDENCE
(2014)
Review
Pharmacology & Pharmacy
Christopher D. Verrico, Colin N. Haile, Thomas F. Newton, Thomas R. Kosten, Richard De La Garza
EXPERT OPINION ON INVESTIGATIONAL DRUGS
(2013)
Article
Genetics & Heredity
Xiang Yang Zhang, Da Chun Chen, Mei Hong Xiu, Colin N. Haile, Xingguang Luo, Ke Xu, Hui Ping Zhang, Lingjun Zuo, Zhijun Zhang, Xiangrong Zhang, Therese A. Kosten, Thomas R. Kosten
Article
Clinical Neurology
C. N. Haile, J. W. Murrough, D. V. Iosifescu, L. C. Chang, R. K. Al Jurdi, A. Foulkes, S. Iqbal, J. J. Mahoney, R. De La Garza, D. S. Charney, T. F. Newton, S. J. Mathew
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
(2014)
Article
Psychology, Clinical
Xiang Yang Zhang, Da Chun Chen, Mei Hong Xiu, Fu De Yang, Colin N. Haile, Therese A. Kosten, Thomas R. Kosten
JOURNAL OF CLINICAL PSYCHIATRY
(2012)
Article
Psychiatry
Xiang Yang Zhang, Da Chun Chen, Mei Hong Xiu, Yun Long Tan, Fu De Yang, Laurence Y. Zhang, Laura Y. Zhang, Colin N. Haile, Thomas R. Kosten
JOURNAL OF PSYCHIATRIC RESEARCH
(2013)
Review
Pharmacology & Pharmacy
Colin N. Haile, James J. Mahoney, Thomas F. Newton, Richard De La Garza
PHARMACOLOGY & THERAPEUTICS
(2012)
Article
Clinical Neurology
R. De La Garza, G. P. Galloway, T. F. Newton, J. Mendelson, C. N. Haile, E. Dib, R. Y. Hawkins, C. -Y. A. Chen, J. J. Mahoney, J. Mojsiak, G. Lao, A. Anderson, R. Kahn
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2014)
Article
Psychology, Clinical
X. Y. Zhang, D. C. Chen, M. H. Xiu, C. N. Haile, S. C. He, X. Luo, L. Zuo, R. Rosenheck, T. A. Kosten, T. R. Kosten
PSYCHOLOGICAL MEDICINE
(2013)
Article
Psychiatry
Colin N. Haile, Thomas R. Kosten
CURRENT PSYCHIATRY REPORTS
(2013)
Article
Neurosciences
Colin N. Haile, Yanli Hao, Patrick W. O'Malley, Thomas F. Newton, Therese A. Kosten