Journal
AMERICAN JOURNAL OF DRUG AND ALCOHOL ABUSE
Volume 34, Issue 3, Pages 293-305Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/00952990802013565
Keywords
cocaine; inhibition; methylphenidate; modafinil; response; stimulants
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Funding
- NIDA NIH HHS [DA 012665] Funding Source: Medline
- NATIONAL INSTITUTE ON DRUG ABUSE [R01DA012665] Funding Source: NIH RePORTER
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Two experiments were conducted to determine whether methylphenidate or modafinil, two potential pharmacotherapies for stimulant dependence, would impair inhibitory behavior in cocaine users. Eleven cocaine abusers were administered methylphenidate (0, 15, 30, and 45 mg) or modafinil (0, 150, 300, and 450 mg) across four experimental sessions. A cued go-no-go task was used to measure response execution and inhibition. Subjective and cardiovascular measures were collected. Neither methylphenidate nor modafinil impaired inhibitory control, but produced prototypical subject-rated and cardiovascular effects. The results of these studies may have implications for the use of these drugs as agonist-replacement therapies for stimulant dependence.
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