Article
Microbiology
Chaitanya Kurhade, Soowon Kang, Scott B. Biering, Seungmin Hwang, Glenn Randall
Summary: This study reveals the collaborative action of autophagy and interferon in inhibiting viral replication. It also uncovers the mechanism by which autophagy proteins target viral replication complexes and the role of interferon-inducible GTPases in disrupting these complexes. This research provides a new understanding of the recognition and inhibition of viral replication complexes by the autophagy machinery.
Editorial Material
Medicine, General & Internal
Francesca Ambrogio, Alexandre Raphael Meduri, Giovanni Infante, Melita Anna Poli, Paolo Romita, Domenico Bonamonte, Raffaele Filotico, Giuseppe Ingravallo, Gerardo Cazzato, Carmelo Laface, Aurora De Marco, Caterina Foti
Summary: Healing viral warts in immunocompromised patients is difficult, but immunocompetent patients can be treated with various methods like topical ointments, cryotherapy, laser therapy, imiquimod, and photodynamic therapy (PDT). PDT has been found to be a valid option for immunocompromised patients, who are at a higher risk of relapse.
Article
Multidisciplinary Sciences
Hanna Brattgard, Per Bjoerkman, Piotr Nowak, Carl Johan Treutiger, Magnus Gisslen, Olof Elvstam
Summary: Among Swedish PWH, low-level viremia (LLV) during antiretroviral therapy (ART) was associated with markers of HIV disease severity before starting ART, male sex, injecting drug use, and use of protease inhibitor (PI)-based or non-standard ART regimens.
Article
Chemistry, Multidisciplinary
Juliane Brun, Snezana Vasiljevic, Bevin Gangadharan, Mario Hensen, Anu Chandran, Michelle L. Hill, J. L. Kiappes, Raymond A. Dwek, Dominic S. Alonzi, Weston B. Struwe, Nicole Zitzmann
Summary: The study demonstrates the differences in site-specific glycosylation between virus-derived spikes, wild-type non-stabilized spikes, and recombinant engineered spike glycoproteins. Additionally, it shows that their unique cellular secretion pathways lead to distinct protein glycosylation and secretion patterns, including shedding of spike monomeric subunits for the non-stabilized wild-type spike, potentially impacting the resulting immune response and vaccine design.
ACS CENTRAL SCIENCE
(2021)
Article
Multidisciplinary Sciences
Rhian Jones, Gabriel Bragagnolo, Rocio Arranz, Juan Reguera
Summary: Positive-sense single-stranded RNA viruses, such as coronaviruses, flaviviruses and alphaviruses, replicate and transcribe within virus-induced membranous organelles in host cells. The remodeling of host-cell membranes for organelle formation allows concentration of metabolites and proteins for viral RNA synthesis, while preventing detection by the cellular innate immune system. The structure of non-structural protein 1 (nsP1) of the alphavirus chikungunya virus reveals the mechanism of RNA capping and membrane binding, providing insights into viral replication complex formation and potential antiviral strategies.
Article
Multidisciplinary Sciences
Huan Liu, Dexi Liu
Summary: In this study, a novel SARS-CoV-2 viral vector was developed, allowing for investigation by the broader scientific community. The vector transduces target cells in an ACE2-dependent manner, and the incorporation of the VEEV self-amplification mechanism increases gene expression level and extends transgene expression time. Furthermore, the vector has significant applications in neutralizing antibody quantification and antiviral drug testing.
SCIENTIFIC REPORTS
(2023)
Article
Multidisciplinary Sciences
Matthew R. Lanahan, Robert W. Maples, Julie K. Pfeiffer
Summary: RNA viruses can mutate to increase replication speed in cultured cells, but this may come at the cost of reduced stability and fitness. Selecting for the earliest viral progeny can reveal unexpected inefficiencies in the viral replication cycle.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Chemistry, Multidisciplinary
Yao Fan, Xiang Li, Lei Zhang, Zhi Zong, Fangwei Wang, Jun Huang, Linghui Zeng, Chong Zhang, Haiyan Yan, Long Zhang, Fangfang Zhou
Summary: SUMOylation, a post-translational modification, plays a crucial role in regulating viral protein function and host antiviral immune response. The review summarizes the regulatory mechanisms of SUMOylation in viral replication and infection, and discusses its potential therapeutic applications in virus-induced diseases.
Article
Virology
Diogo C. Mendonca, Erik. V. S. Reis, Nidia. E. C. Arias, Hugo J. Valencia, Claudio A. Bonjardim
Summary: Mayaro virus (MAYV) is a neglected disease mainly found in Central and South America, causing a febrile illness and long-term debilitating arthritis. This study analyzed the viral replication kinetics and discovered the chronological order of events during MAYV replication, providing new insights into the virus's replication cycle. The findings could contribute to future research in the field.
Article
Microbiology
D. Hoffman, W. Rodriguez, D. Macveigh-Fierro, J. Miles, M. Muller
Summary: This study explores the role of the poorly characterized viral protein ORF20 in KSHV replication, showing its interaction with ORF59 in replication compartments and its impact on DNA replication and late viral lifecycle stages. These findings suggest ORF20's potential contribution as a key modulator of the complex lytic DNA replication process within KSHV.
MICROBIOLOGY SPECTRUM
(2021)
Article
Multidisciplinary Sciences
Leviel Fluhr, Uria Mor, Aleksandra A. Kolodziejczyk, Mally Dori-Bachash, Avner Leshem, Shlomik Itav, Yotam Cohen, Jotham Suez, Niv Zmora, Claudia Moresi, Shahar Molina, Niv Ayalon, Rafael Valdes-Mas, Shanni Hornstein, Hodaya Karbi, Denise Kviatcovsky, Adi Livne, Aurelie Bukimer, Shimrit Eliyahu-Miller, Alona Metz, Alexander Brandis, Tevie Mehlman, Yael Kuperman, Michael Tsoory, Noa Stettner, Alon Harmelin, Hagit Shapiro, Eran Elinav
Summary: Smoking and cessation induce a dysbiotic state in the intestines, leading to weight gain. Depletion of gut microbiota induced by antibiotics prevents weight gain after smoking cessation.
Article
Biochemistry & Molecular Biology
Jayaraju Dheekollu, Andreas Wiedmer, Kasirajan Ayyanathan, Julianna S. Deakyne, Troy E. Messick, Paul M. Lieberman
Summary: This study reveals that EBNA1 forms cell cycle-dependent DNA crosslinks with the EBV origin of plasmid replication and the tyrosine 518 residue is essential for this process. These crosslinks and single-strand cleavage are critical for replication termination and viral episome maintenance.
Article
Multidisciplinary Sciences
Rafail Nikolaos Tasakis, Georgios Samaras, Anna Jamison, Michelle Lee, Alexandra Paulus, Gabrielle Whitehouse, Laurent Verkoczy, F. Nina Papavasiliou, Marilyn Diaz
Summary: This study explores the evolution, key mutations, and features of the SARS-CoV-2 genome in the United States, and found many accumulating Single Nucleotide Variations (SNVs) in the virus genome throughout 2020 and early 2021. The results suggest that viral genomes are dynamically evolving over time, with periods of mutational bursts and unabated mutation accumulation. The high level of existing variation, especially in the Spike-encoding region, may become problematic during super-spreader events, driving rare mutations to prominence.
Article
Multidisciplinary Sciences
Audrey Labarde, Lina Jakutyte, Cyrille Billaudeau, Beatrix Fauler, Maria Lopez-Sanz, Prishila Ponien, Eric Jacquet, Thorsten Mielke, Silvia Ayora, Rut Carballido-Lopez, Paulo Tavares
Summary: Infection of Bacillus subtilis by bacteriophage SPP1 leads to the hijacking of host replication proteins to assemble hybrid viral-bacterial replisomes, doubling the cell total DNA content within 15 minutes. The replisomes operate at several independent locations within a single viral DNA focus positioned asymmetrically in the cell. These findings demonstrate that bacteriophages restructure the host cytoplasm to confine the essential processes for their multiplication at different cellular locations.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Microbiology
Jianli Tang, Sahibzada Waheed Abdullah, Pinghua Li, Jin'en Wu, Chenchen Pei, Suyu Mu, Yunlu Wang, Shiqi Sun, Huichen Guo
Summary: This study reveals the crucial role of HSP60 in FMDV infection, including its involvement in viral RNA replication and mRNA translation, as well as its interaction with FMDV nonstructural proteins 3A and 2C in the replication complex. Modulating the expression of HSP60 can significantly reduce the pathogenicity of FMDV.
Article
Infectious Diseases
Chris Kenyon, Achilleas Tsoumanis, Kara Osbak, Marjan van Esbroeck, Eric Florence, Tania Crucitti, Luc Kestens
SEXUALLY TRANSMITTED INFECTIONS
(2018)
Article
Immunology
Ralph Huits, Patrick Soentjens, Ula Maniewski-Kelner, Caroline Theunissen, Steven Van Den Broucke, Eric Florence, Jan Clerinx, Erika Vlieghe, Jan Jacobs, Lieselotte Cnops, Dorien Van Den Bossche, Marjan Van Esbroeck, Emmanuel Bottieau
OPEN FORUM INFECTIOUS DISEASES
(2017)
Article
Infectious Diseases
T. Platteau, J. van Lankveld, L. Apers, K. Fransen, J. Rockstroh, E. Florence
Article
Medicine, General & Internal
Stephane De Wit, Eric Florence, Linos Vandekerckhove, Bernard Vandercam, Jean-Christophe Goffard, Eric Van Wijngaerden, Michel Moutschen, Remy Demeester, Pushpike Thilakarathne, Hilde Piryns
ACTA CLINICA BELGICA
(2018)
Article
Medicine, General & Internal
Agnes Libois, Eric Florence, Inge Derdelinckx, Jean Cyr Yombi, Sophie Henrard, Francoise Uurlings, Stefaan Vandecasteele, Sabine D. Allard, Remy Demeester, Filip Van Wanzeele, Nathalie Ausselet, Stephane De Wit
ACTA CLINICA BELGICA
(2018)
Article
Medicine, General & Internal
Stephane De Wit, Eric Florence, Linos Vandekerkhove, Jean-Christophe Goffard, Bernard Vandercam, Eric Van Wijngaerden, Michel Moutschen, Remy Demeester, Patrick Lacor, Marc Delforge, Maartje van Frankenhuijsen, Paul Lacante
ACTA CLINICA BELGICA
(2019)
Article
Multidisciplinary Sciences
Christine Grady, Giota Touloumi, A. Sarah Walker, Mary Smolskis, Shweta Sharma, Abdel G. Babiker, Nikos Pantazis, Jorge Tavel, Eric Florence, Adriana Sanchez, Fleur Hudson, Antonios Papadopoulos, Ezekiel Emanuel, Megan Clewett, David Munroe, Eileen Denning
Article
Multidisciplinary Sciences
Anja De Weggheleire, Sokkab An, Irith De Baetselier, Pisith Soeung, Huy Keath, Veasna So, Sreyphors Ros, Syna Teav, Bart Smekens, Jozefien Buyze, Eric Florence, Johan van Griensven, Sopheak Thai, Sven Francque, Lutgarde Lynen
Article
Immunology
Kamilla Gronborg Laut, Leah Shepherd, Magnus Gottfredsson, Dalibor Sedlacek, Brygida Knysz, Josip Begovac, Roxana Radoi, Brigitte Schmied, Nikoloz Chkhartishvili, Eric Florence, Matti Ristola, Gerd Faetkenheuer, Fiona Mulcahy, Patrick Schmid, Elena Kuzovatova, Dzmitry Paduta, Jelena Smidt, Pere Domingo, Janos Szlavik, Jens Lundgren, Amanda Mocroft, Ole Kirk
Article
Infectious Diseases
Chris Kenyon, Kristien Wouters, Tom Platteau, Jozefien Buyze, Eric Florence
AIDS RESEARCH AND THERAPY
(2018)
Article
Microbiology
Caroline Theunissen, Emmanuel Bottieau, Marjan Van Esbroeck, Achilleas Tsoumanis, Eric Florence
Article
Infectious Diseases
D. Van Beckhoven, E. Florence, S. De Wit, C. Wyndham-Thomas, A. Sasse, H. Van Oyen, J. Macq
Article
Environmental Sciences
Corinne Herrijgers, Karolien Poels, Heidi Vandebosch, Tom Platteau, Jacques van Lankveld, Eric Florence
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2020)
Article
Infectious Diseases
Dana Busschots, Cecile Kremer, Ozgur M. Koc, Leen Heyens, Rob Bielen, Ludwig Apers, Eric Florence, Peter Messiaen, Kristel Van Laethem, Eric Van Wijngaerden, Frederik Nevens, Niel Hens, Geert Robaeys
Summary: This study investigated the HCV infection situation of 4607 PLHIV in Belgium, with high rates of treatment initiation and sustained virologic response (SVR). Implementation of a national HCV register for tracking progress and yearly screening is crucial for achieving HCV elimination in PLHIV by 2030.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Health Care Sciences & Services
Corinne Herrijgers, Tom Platteau, Heidi Vandebosch, Karolien Poels, Eric Florence
Summary: This study developed a mobile health intervention tool named Budd using the intervention mapping protocol to support and inform MSM engaging in chemsex, reducing negative impacts, and promoting more reasoned participation.
JMIR RESEARCH PROTOCOLS
(2022)
