Journal
ACS BIOMATERIALS SCIENCE & ENGINEERING
Volume 1, Issue 7, Pages 494-503Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ab5001468
Keywords
functionalization; silk fibroin; isoelectric point
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Funding
- National Natural Science Foundation of China [21204011]
- Major Project of Chinese National Programs for Fundamental Research and Development (973 Program) [2011CB606100]
- National Higher-education Institution General Research and Development Project
- State Key Laboratory for Modification of Chemical Fibers and Polymer Materials (SKLFPM)
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Recent works by Tansil et al. suggested a promising way to introduce functionalities into silk fibroin by simply feeding, which was expected to allow silk-based functional biomaterials to have scalable production and direct application. In this research, we aimed to obtain deeper understanding on such a smart strategy of selectively absorbing additives via molecular recognition and the impact of additives on the secondary structures of fibroin. We suggested that the partition ratio of the additive in fibroin and sericin was a critical parameter to evaluate the ability of the additive to enter fibroin, which showed a strong correlation with the isoelectric point (pI) of the additive. On the basis of the classical micelle model, we suggested that silk in vivo recognized additives with low pI and amphiphile chemical structure from other chemical similar additives and assembled them into fibroin. Fibroin-additive assemblies were rather stable that hindered the formation of beta-sheet and also crystallites, as indicated by FTIR and WAXD.
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