Article
Chemistry, Multidisciplinary
Hiralben D. Atara, Gaurangkumar C. Brahmbhatt, Vishalkumar M. Parmar, Narsidas J. Parmar, Vivek K. Gupta
Summary: A chitosan-catalyzed domino aldol-hetero-Diels-Alder reaction in glycerol was developed to synthesize pyrano and thiopyrano compounds containing cyclic heptanoid core. The method showed high efficiency with a model compound yield of 91%, and provided important insights into the stereochemical output of the reaction. Both chitosan and glycerol could be recycled at least five times without loss of efficiency.
Article
Chemistry, Applied
Chima E. Anyaegbu, Haonan Zhang, Jian Xiao, Minli Tao, Ning Ma, Wenqin Zhang
Summary: Polyacrylonitrile fiber supported bisquaternary ammonium salts were successfully synthesized and used as catalysts for the synthesis of various compounds. Among the prepared fiber catalysts, PAN(BQAc)F showed the best catalytic activity and can be used for multiple runs with only a slight decrease in catalytic activity.
REACTIVE & FUNCTIONAL POLYMERS
(2022)
Article
Chemistry, Multidisciplinary
Hitesh B. Jalani, Aneesh Sivaraman, Kyoung Ho Min, Hwa Young Lee, Na Kyoung Oh, Hyeseul Kang, Gyochang Keum, Yongseok Choi, Kyeong Lee
Summary: An expeditious one-pot method for the synthesis of highly substituted 5-aminoimidazoles from glyoxals, anilines, and amidines under metal/catalyst-free conditions operative at room temperature is proposed. The method is environmentally friendly and can be applied to the synthesis of bioactive and medicinal compounds.
Article
Chemistry, Organic
Sifan Li, Yu Wang, Zibo Wu, Weiliang Shi, Yibo Lei, Paul W. Davies, Wei Shu
Summary: A radical triggered fragmentary cyclization cascade reaction is proposed to provide rapid access into [1,2]-annulated indoles. The mechanism involves radical addition, cyclization, aryl migration, and C-N bond cyclization sequence.
Article
Chemistry, Organic
Snehali R. Mali, Sachinkumar K. Shinde, Bhagyashree M. Patil, Rupesh C. Patil, Suresh S. Patil
Summary: In this study, Chickpea leaf exudates (CLEs) were reported as a Bronsted acid for the synthesis of pyran-annulated heterocyclic systems. The reaction showed high efficiency and short reaction time. Moreover, the reaction medium could be easily recovered and reused multiple times.
LETTERS IN ORGANIC CHEMISTRY
(2022)
Article
Chemistry, Organic
Masoumeh Divar, Kamiar Zomorodian, Razieh Sabet, Maryam Moeini, Soghra Khabnadideh
Summary: Oxindoles and spirooxindoles are important synthetic targets due to their biological activity and pharmaceutical applications. In this study, 18 new derivatives of spirooxindoles were synthesized efficiently using a multicomponent reaction method. The chemical structures were confirmed and reaction conditions were optimized for catalysts, temperature, and solvents.
POLYCYCLIC AROMATIC COMPOUNDS
(2021)
Article
Chemistry, Organic
Arup Dutta, Noimur Rahman, John Elisa Kumar, Jintu Rabha, Tridip Phukan, Rishanlang Nongkhlaw
Summary: A convenient and eco-friendly one-pot synthesis method for pharmaceutically important pyran-based heterocyclic compounds was developed, featuring mild, catalyst-free reactions, green procedures, and high yields. This method has the added advantage of scalability for various pyran-based heterocyclic compounds synthesis without the need for expensive catalysts. Additionally, in vitro antibacterial screening of a pyran derivative showed activity against both Gram-positive and Gram-negative bacteria.
SYNTHETIC COMMUNICATIONS
(2021)
Article
Chemistry, Multidisciplinary
Xiyue Peng, Yuan Xie, Ardeshir Baktash, Jiayong Tang, Tongen Lin, Xia Huang, Yuxiang Hu, Zhongfan Jia, Debra J. Searles, Yusuke Yamauchi, Lianzhou Wang, Bin Luo
Summary: The development of cost-effective and long-life rechargeable aluminium ion batteries with a new cathode material has promising prospects for sustainable energy storage applications. By using a low-cost AlCl3/urea electrolyte, a heteroatom pi-conjugated polymer featuring synergistic C=O and C=N active centres is reported to show high discharge capacity and long cycle life, outperforming most Al-organic batteries reported to date.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Review
Chemistry, Organic
Yuan Zhong
Summary: Arylformylacetonitriles are highly reactive synthons in organic synthesis, and multicomponent reactions provide straightforward and effective routes for the synthesis of a wide range of five- and six-membered heterocyclic compounds. This review summarizes the recent advances and applications of arylformylacetonitriles in multicomponent reactions for the synthesis of monocyclic or polycyclic heterocycles since 2001.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2022)
Review
Chemistry, Organic
Natalia M. Moreira, Jhonathan R. N. dos Santos, Arlene G. Correa
Summary: Quinazoline derivatives have garnered attention in synthetic and medicinal chemistry due to their wide range of biological activities and potential pharmacological applications. Recent research has focused on greener methods for synthesizing these compounds.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Farzaneh Mohamadpour
Summary: The use of solar energy as a sustainable energy source for the production of 2-amino-4H-chromene scaffolds through a three-condensation domino reaction is demonstrated in this study, with catalyst-solvent-free conditions resulting in high yields and efficient resource utilization. The method is applicable to a wide range of functional groups, maintaining rapid reaction rates and high yields. This research establishes a fresh purpose for solar energy and provides a productive one-step process for the synthesis of 2-amino-4H-chromene scaffolds.
RESEARCH ON CHEMICAL INTERMEDIATES
(2023)
Review
Chemistry, Organic
Nagaraju Kerru, Lalitha Gummidi, Suresh Maddila, Sreekantha B. Jonnalagadda
Summary: Nitrogen, oxygen, and sulfur-containing fused heterocycles have significant biological activities, and the construction of carbon-nitrogen and carbon-oxygen bonds using eco-friendly heterogeneous catalysts is important for introducing nitrogen and oxygen into organic molecules. The development of green methodologies in synthetic organic chemistry has gained particular significance, with multicomponent reactions and heterogeneous catalyst strategies showing broader scope, economic viability, and sustainability.
CURRENT ORGANIC CHEMISTRY
(2021)
Article
Chemistry, Organic
Israel Nino-Pantoja, Arturo Gallardo-Alfonzo, Melchor Solis-Santos, Mario Ordonez, Claudia Contreras-Celedon, Alejandro Islas-Jacome, Luis Chacon-Garcia, Carlos J. Cortes-Garcia
Summary: A novel bis-heterocyclic system containing 1,2-dihydro-3H-pyrrolo[3,4-b]indolizin-3-one and 1,5-disubstituted tetrazole moieties was designed and synthesized as a Copper (II) recognizing agent. The compounds were prepared using a novel one-pot synthetic strategy involving four-step reactions. The photophysical properties of the obtained compounds were evaluated for their response to Copper (II).
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Nusrat Sahiba, Ayushi Sethiya, Pankaj Teli, Shikha Agarwal
Summary: A facile, efficient, and green method for the synthesis of hexahydroquinolines using [H2-DABCO][HSO4]2 ionic liquid catalyst was reported. The method showed excellent yields (76-100%) under ambient reaction conditions and short reaction time. The greenness of the method was confirmed through eco-score and E-factor evaluation, making it suitable for both industry and academia.
Article
Biochemistry & Molecular Biology
Dmytro S. Radchenko, Vasyl S. Naumchyk, Igor Dziuba, Andrii A. Kyrylchuk, Kateryna E. Gubina, Yurii S. Moroz, Oleksandr O. Grygorenko
Summary: The three-component one-pot approach described in this study successfully synthesized unsymmetrical 1,3,5-trisubstituted-1,2,4-triazoles, with a high success rate of 81%. The methodology shows great potential for generating a large number of REAL compounds, some of which meet lead-likeness criteria and can be valuable in medicinal chemistry.
MOLECULAR DIVERSITY
(2022)
Article
Chemistry, Multidisciplinary
Varun Sharma, Indrajit Karmakar, Goutam Brahmachari, Vivek Kumar Gupta
Summary: A novel molecule, isopropyl 5-chloro-2-hydroxy-3-oxo-2,3-dihydrobenzofuran-2-carboxylate (mf. C12H11ClO5), synthesized under visible-light induced singlet oxygen, has been studied for its spectral properties and crystal structure. The crystal structure exhibits complex hydrogen bonding interactions to form supramolecular structures. Furthermore, in silico drug likeness screening and molecular docking studies for antifungal activity have been conducted.
MOLECULAR CRYSTALS AND LIQUID CRYSTALS
(2022)
Article
Multidisciplinary Sciences
Arvind Singh, Amartya Basu, Aditi Sharma, Anu Priya, Manmmet Kaur, Gurpreet Kaur, Bubun Banerjee
Summary: This review presents the diverse synthetic methods of lawsone derived scaffolds and their promising results against various anti-cancer cell lines.
PHYSICAL SCIENCES REVIEWS
(2022)
Article
Chemistry, Organic
Mahdia Hamidinasab, Najmieh Ahadi, Mohammad Ali Bodaghifard, Goutam Brahmachari
Summary: The design and development of eco-friendly procedures for synthesizing organic compounds is crucial in synthetic chemistry. Catalysts increase reaction rates and offer advantages such as reduced energy input, diminished environmental impact, and financial benefit. Combining multicomponent reactions (MCRs) with natural catalysts is a strategic approach for sustainable organic synthesis.
POLYCYCLIC AROMATIC COMPOUNDS
(2023)
Article
Chemistry, Physical
Bubun Banerjee, Anu Priya, Manmeet Kaur, Aditi Sharma, Arvind Singh, Vivek Kumar Gupta, Vikas Jaitak
Summary: A facile and convenient method has been developed to synthesize 2-amino-3-cyano substituted tetrahydrobenzo[b]pyran derivatives and spiropyrans in water at room temperature. The reaction only takes 2.5 hours and yields excellent results without the need for column chromatographic purification. Major advantages of this method include the use of water as a green solvent, a commercially available low-cost catalyst, high atom economy, and energy efficiency.
Article
Chemistry, Organic
Nayana Nayek, Goutam Brahmachari
Summary: A photochemical method using visible light (white LEDs/sunlight) has been developed for efficient and selective C(sp(2))-H selenylation and sulfenylation of substituted 2-amino-1,4-naphthoquinones. This metal-free protocol offers the advantages of no external photoredox catalysts, use of visible light/sunlight as energy sources, good substrate scope, and moderate to good yields (41-91%) with high regioselectivity.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Chemistry, Organic
Pintu Karmakar, Indrajit Karmakar, Debopam Pal, Suravi Das, Goutam Brahmachari
Summary: A straightforward and efficient electrochemical method has been discovered for regioselective C(sp(2))-H selenylation and sulfenylation of substituted 2-amino-1,4-naphthoquinones. This oxidative cross-coupling reaction avoids the use of transition metal catalysts, oxidants, and high temperatures. The protocol also offers tolerance of diverse functional groups, mild reaction conditions at ambient temperature, energy efficiency, good to excellent yields, short reaction times (in minutes), gram-scale applicability, and eco-friendliness.
JOURNAL OF ORGANIC CHEMISTRY
(2023)
Review
Chemistry, Organic
Bubun Banerjee, Arvind Singh, Aditi Sharma, Anu Priya, Manmeet Kaur, Gurpreet Kaur
Summary: Selenium is an essential nutrient in many selenoproteins and can be found in various selenium-containing compounds with broad biological activities. Organoselenium chemistry has expanded widely in the past decades with numerous methods reported for the synthesis of diverse organoselenium compounds. Ultrasound-assisted protocols have shown advantages over traditional thermal methods in terms of reaction times, yields, product selectivity, and purity. This review summarizes the recent literature on the ultrasound-assisted synthesis of various organoselenium scaffolds under diverse reaction conditions.
CURRENT ORGANIC CHEMISTRY
(2023)
Article
Chemistry, Organic
Anindita Bhowmick, Goutam Brahmachari
Summary: An efficient and straightforward method for synthesizing functionalized 4-aminocoumarins from coumarin-3-carboxylic acids has been developed. This protocol involves decarboxylation, C-sp2-H dehydrogenative C-N cross-coupling, and is performed under ambient conditions. The advantages include tolerance of diverse functional groups, mild reaction conditions, short reaction times, high regioselectivity, gram-scale applicability, and eco-friendliness.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2023)
Review
Chemistry, Organic
Bubun Banerjee, Anu Priya, Jaswinder Kaur, Manmeet Kaur, Arvind Singh, Aditi Sharma
Summary: Cyanuric chloride is a green source for generating hydrochloric acid and has been widely used as a metal-free organocatalyst. It has shown great efficiency in various organic transformations, leading to the synthesis of biologically active heterocylic scaffolds. Over the past two decades, it has gained significant attention in the field of organic synthesis.
SYNTHETIC COMMUNICATIONS
(2023)
Article
Chemistry, Multidisciplinary
Pintu Karmakar, Indrajit Karmakar, Debojyoti Mukherjee, Anindita Bhowmick, Goutam Brahmachari
Summary: A practical and efficient synthetic method for accessing diverse series of biologically relevant poly-functionalized 5-(arylselanyl)-1H-1,2,3-triazoles has been developed via copper(I)-catalyzed click reaction and high-speed ball-milling. This method offers operational simplicity, solvent-free and external heating-free conditions, one-pot synthesis, short reaction time, high yields, broad substrate scope, and gram-scale applications. Furthermore, the synthesized organoselenium compounds can be further diversified to biologically promising selenones.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Article
Chemistry, Organic
Anindita Bhowmick, Goutam Brahmachari
Summary: A practical and efficient method for the synthesis of functionalized 4-(aryl-/heteroaryl-ethynyl)chroman-2-ones and 2-(aryl-/heteroaryl-ethynyl)chroman-4-ones through copper-catalyzed decarboxylative direct cross-coupling of coumarin-/chromone-3-carboxylic acids with terminal alkynes, leading to the formation of C(sp)-C(sp(3)) bonds, has been discovered. This protocol offers several advantages, including avoidance of ligands and bases, a wide range of substrate compatibility, tolerance to diverse functional groups, and good to excellent yields.
Article
Chemistry, Organic
Bubun Banerjee, Arvind Singh, Aditi Sharma, Anu Priya, Manmeet Kaur, Vivek Kumar Gupta
Summary: A method for the synthesis of benzo[3,4-a]phenazin-5-ol and benzo[f]pyrido[2,3-b]quinoxalin-5-ol derivatives using trisodium citrate as a catalytic organo-catalyst in aqueous ethanol at room temperature was developed. The method offers mild reaction conditions, metal-free organocatalyst, nontoxic solvent, energy efficiency, no column chromatographic separation, gram scale production, and reusability of the catalyst-containing solvent media.
POLYCYCLIC AROMATIC COMPOUNDS
(2023)
Article
Chemistry, Organic
Ambrish Kumar Srivastava, Abhishek Kumar, Harshita Srivastava, Saurabh Pandey, Narendra Kumar, Goutam Brahmachari, Neeraj Misra
Summary: In this study, the spectral characterization of piperine extracted from black pepper was performed using FT-IR, H-1-NMR, and C-13-NMR. The vibrational modes and chemical shifts of piperine were determined through calculations and showed good agreement with experimental data. Molecular docking and dynamics simulation indicated the potential anti-inflammatory action of piperine.
POLYCYCLIC AROMATIC COMPOUNDS
(2023)
Article
Chemistry, Multidisciplinary
Bubun Banerjee, Manmeet Kaur, Varun Sharma, Vivek Kumar Gupta, Jaswinder Kaur, Aditi Sharma, Anu Priya, Arvind Singh
Summary: A simple and convenient protocol for the synthesis of 1,8-dioxo-octahydroxanthenes has been developed using a one-pot pseudo three-component reaction. The reaction involves dimedone, aromatic aldehydes, and camphor sulfonic acid as a catalyst. The method offers advantages such as the use of an organocatalyst, simple work up procedure, high atom economy, multicomponent strategy, and easy isolation procedure.
RESEARCH ON CHEMICAL INTERMEDIATES
(2023)
Article
Chemistry, Organic
Pintu Karmakar, Indrajit Karmakar, Debopam Pal, Suravi Das, Goutam Brahmachari
Summary: A straightforward and efficient electrochemical method has been discovered for regioselective C(sp(2))-H selenylation and sulfenylation of substituted 2-amino-1,4-naphthoquinones. This method avoids the use of transition metal catalysts, oxidants, and high temperatures. Other notable advantages include tolerance of diverse functional groups, mild reaction conditions at ambient temperature, energy efficiency, good to excellent yields, short reaction times (in minutes), gram-scale applicability, and eco-friendliness.
JOURNAL OF ORGANIC CHEMISTRY
(2023)
