Journal
ACS SUSTAINABLE CHEMISTRY & ENGINEERING
Volume 1, Issue 5, Pages 545-548Publisher
AMER CHEMICAL SOC
DOI: 10.1021/sc4000253
Keywords
Green chemistry; Alcoholic solvent; Platinum catalysis; Heterocycle; Multifaceted catalysis
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Funding
- School of Chemistry at the University of Nottingham
- EPSRC [EP/J003298/1]
- Engineering and Physical Sciences Research Council [EP/J003298/1] Funding Source: researchfish
- EPSRC [EP/J003298/1] Funding Source: UKRI
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Two complementary approaches for the direct synthesis of 2-dichloro- and 2-trichlorobenzoxazoles from 2-aminophenols and halogenated nitriles are reported. A green, noncatalyzed method was shown: to proceed in an alcoholic, solvent without the addition of exogenous acid or base., This method, provides a clean and robust synthesis of these important heterocycles, which contain a key functional group handle at the 2-position. A complementary platinum multifaceted catalysis approach was also developed in which the metal can catalyzes multiple mechanistically distinct processes. This method allows for an improved use of the metal catalyst vs stepwise protocols and provides increased flexibility in the choice of reaction conditions.
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