Journal
ZEITSCHRIFT FUR GEBURTSHILFE UND NEONATOLOGIE
Volume 217, Issue 1, Pages 24-27Publisher
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0032-1333256
Keywords
smoking; hypertensive disorders; pregnancy
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Background: We have previously described the prevalence in pregnancy of hypertension, proteinuria, oedema and preeclampsia/eclampsia according to maternal body mass index (BMI) and smoking status. We found that these disorders were less frequent among smoking women. To investigate whether this relationship is causal or a chance finding, we here present an analysis according to BMI and smoking specified according to the number of cigarettes consumed per day. Materials and Methods: Data were from the German Perinatal Survey of 1998-2000. We classified women by BMI as underweight (BMI < 18.5 kg/m(2)), normal weight (BMI 18.5-24.99 kg/m(2)), overweight (25.0-29.99 kg/m(2)), or obese (BMI >= 30 kg/m(2)). Smoking was categorised as being a non-smoker or smoking 1-7, 8-14 or >= 15 cigarettes per day. Datasets from 433 669 singleton pregnancies with information on maternal BMI and smoking were included in the analysis. Results: In all BMI categories hypertension, moderate to severe oedema, and preeclampsia/eclampsia became less prevalent with increasing maternal cigarette consumption. Dose-dependence was not convincing for proteinuria. Conclusions: Dose-dependence in the relationship between smoking and hypertensive disorders of pregnancy argues against a chance finding and for a causal relationship.
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