Messenger RNA-based vaccines: progress, challenges, applications

Strategic priorities for respiratory syncytial virus (RSV) vaccine development

(2013) L.J. Anderson et al.   VACCINE

A triple helix stabilizes the 3' ends of long noncoding RNAs that lack poly(A) tails

(2012) J. E. Wilusz et al.   GENES & DEVELOPMENT

Human Toll-Like Receptor 8 Can Be Cool Too: Implications for Foreign RNA Sensing

(2012) Soroush T. Sarvestani et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Type I IFN Counteracts the Induction of Antigen-Specific Immune Responses by Lipid-Based Delivery of mRNA Vaccines

(2012) Charlotte Pollard et al.   MOLECULAR THERAPY

Systematic discovery of structural elements governing stability of mammalian messenger RNAs

(2012) Hani Goodarzi et al.   NATURE

Novel role of PKR in inflammasome activation and HMGB1 release

(2012) Ben Lu et al.   NATURE

An mRNA vaccine for influenza

(2012) Sook-San Wong et al.   NATURE BIOTECHNOLOGY

Protective efficacy of in vitro synthesized, specific mRNA vaccines against influenza A virus infection

(2012) Benjamin Petsch et al.   NATURE BIOTECHNOLOGY

Regulation of cytoplasmic mRNA decay

(2012) Daniel R. Schoenberg et al.   NATURE REVIEWS GENETICS

Selection of a T7 promoter mutant with enhanced in vitro activity by a novel multi-copy bead display approach for in vitro evolution

(2012) Siddhartha Paul et al.   NUCLEIC ACIDS RESEARCH

Discovery of T Cell Antigens by High-Throughput Screening of Synthetic Minigene Libraries

(2012) Brian D. Hondowicz et al.   PLoS One

Developing mRNA-vaccine technologies

(2012) Thomas Schlake et al.   RNA Biology

RNA-based vaccines

(2012) Jeffrey B. Ulmer et al.   VACCINE

The Elongation, Termination, and Recycling Phases of Translation in Eukaryotes

(2012) T. E. Dever et al.   Cold Spring Harbor Perspectives in Biology

The Mechanism of Eukaryotic Translation Initiation: New Insights and Challenges

(2012) A. G. Hinnebusch et al.   Cold Spring Harbor Perspectives in Biology

Protein-RNA footprinting: an evolving tool

(2012) Dominique Fourmy et al.   Wiley Interdisciplinary Reviews-RNA

Nucleic Acid Recognition by the Innate Immune System

(2011) Roman Barbalat et al.   Annual Review of Immunology

Codon usage: Nature's roadmap to expression and folding of proteins

(2011) Evelina Angov   Biotechnology Journal

TLR7 enables cross-presentation by multiple dendritic cell subsets through a type I IFN-dependent pathway

(2011) J. Z. Oh et al.   BLOOD

Non-conventional sources of peptides presented by MHC class I

(2011) Shelley R. Starck et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Tumor vaccination using messenger RNA: prospects of a future therapy

(2011) Sebastian Kreiter et al.   CURRENT OPINION IN IMMUNOLOGY

mRNA vaccination as a safe approach for specific protection from type I allergy

(2011) Richard Weiss et al.   Expert Review of Vaccines

Selective uptake of naked vaccine RNA by dendritic cells is driven by macropinocytosis and abrogated upon DC maturation

(2011) M Diken et al.   GENE THERAPY

Selective Utilization of Toll-like Receptor and MyD88 Signaling in B Cells for Enhancement of the Antiviral Germinal Center Response

(2011) Baidong Hou et al.   IMMUNITY

Intradermal Immunization Triggers Epidermal Langerhans Cell Mobilization Required for CD8 T-Cell Immune Responses

(2011) Christelle Liard et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Detection of prokaryotic mRNA signifies microbial viability and promotes immunity

(2011) Leif E. Sander et al.   NATURE

Immunological mechanisms of vaccination

(2011) Bali Pulendran et al.   NATURE IMMUNOLOGY

Generating the optimal mRNA for therapy: HPLC purification eliminates immune activation and improves translation of nucleoside-modified, protein-encoding mRNA

(2011) Katalin Karikó et al.   NUCLEIC ACIDS RESEARCH

Multiparameter RNA and Codon Optimization: A Standardized Tool to Assess and Enhance Autologous Mammalian Gene Expression

(2011) Stephan Fath et al.   PLoS One

Direct activation of antigen-presenting cells is required for CD8+ T-cell priming and tumor vaccination

(2011) W. Kratky et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protein expression from exogenous mRNA: Uptake by receptor-mediated endocytosis and trafficking via the lysosomal pathway

(2011) Christina Lorenz et al.   RNA Biology

Determinants of intracellular RNA pharmacokinetics: Implications for RNA-based immunotherapeutics

(2011) Andreas N. Kuhn et al.   RNA Biology

Particle size and activation threshold: a new dimension of danger signaling

(2010) L. Rettig et al.   BLOOD

Plasmacytoid dendritic cell-derived type I interferon is crucial for the adjuvant activity of Toll-like receptor 7 agonists

(2010) D. Rajagopal et al.   BLOOD

Intranodal Vaccination with Naked Antigen-Encoding RNA Elicits Potent Prophylactic and Therapeutic Antitumoral Immunity

(2010) S. Kreiter et al.   CANCER RESEARCH

Skeletal muscle cells: from local inflammatory response to active immunity

(2010) M Marino et al.   GENE THERAPY

From Vaccines to Memory and Back

(2010) Federica Sallusto et al.   IMMUNITY

DNA vaccines: an historical perspective and view to the future

(2010) Margaret A. Liu   IMMUNOLOGICAL REVIEWS

Messenger RNA-based Vaccines With Dual Activity Induce Balanced TLR-7 Dependent Adaptive Immune Responses and Provide Antitumor Activity

(2010) Mariola Fotin-Mleczek et al.   JOURNAL OF IMMUNOTHERAPY

Synonymous but not the same: the causes and consequences of codon bias

(2010) Joshua B. Plotkin et al.   NATURE REVIEWS GENETICS

The RNA modification database, RNAMDB: 2011 update

(2010) W. A. Cantara et al.   NUCLEIC ACIDS RESEARCH

An Accessory to the ‘Trinity’: SR-As Are Essential Pathogen Sensors of Extracellular dsRNA, Mediating Entry and Leading to Subsequent Type I IFN Responses

(2010) Stephanie J. DeWitte-Orr et al.   PLoS Pathogens

Control of poly(A) tail length

(2010) Christian R. Eckmann et al.   Wiley Interdisciplinary Reviews-RNA

Dendritic cell subsets in primary and secondary T cell responses at body surfaces

(2009) William R Heath et al.   NATURE IMMUNOLOGY

An unexpected ending: Noncanonical 3' end processing mechanisms

(2009) J. E. Wilusz et al.   RNA

A detailed characterisation of the distribution and presentation of DNA vaccine encoded antigen

(2009) Catherine M. Rush et al.   VACCINE

Ancient News: HMGBs are Universal Sentinels

(2009) M. E. Bianchi et al.   Journal of Molecular Cell Biology

Tumor therapy in mice via antigen targeting to a novel, DC-restricted C-type lectin

(2008) David Sancho et al.   JOURNAL OF CLINICAL INVESTIGATION

Transterm: a database to aid the analysis of regulatory sequences in mRNAs

(2008) G. H. Jacobs et al.   NUCLEIC ACIDS RESEARCH