Journal
WILEY INTERDISCIPLINARY REVIEWS-RNA
Volume 4, Issue 2, Pages 181-203Publisher
WILEY
DOI: 10.1002/wrna.1153
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Funding
- National Institutes of Health [R01-GM079604]
- NSF [MCB-1158577]
- David and Lucile Packard Foundation
- Direct For Biological Sciences [1158577] Funding Source: National Science Foundation
- Div Of Molecular and Cellular Bioscience [1158577] Funding Source: National Science Foundation
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Complex natural RNAs such as the ribosome, group I and group II introns, and RNase P exemplify the fact that three-dimensional (3D) RNA structures are highly modular and hierarchical in nature. Tertiary RNA folding typically takes advantage of a rather limited set of recurrent structural motifs that are responsible for controlling bends or stacks between adjacent helices. Herein, the GA minor and related structural motifs are presented as a case study to highlight several structural and folding principles, to gain further insight into the structural evolution of naturally occurring RNAs, as well as to assist the rational design of artificial RNAs. WIREs RNA 2013, 4:181203. doi: 10.1002/wrna.1153 For further resources related to this article, please visit the WIREs website.
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