A mirror of two faces: Lin28 as a master regulator of both miRNA and mRNA

Does Lin28 Antagonize miRNA-Mediated Repression by Displacing miRISC from Target mRNAs?

(2012) Amanda N. Kallen et al.   Frontiers in Genetics

A LIN28-Dependent Structural Change in pre-let-7g Directly Inhibits Dicer Processing

(2011) Helen L. Lightfoot et al.   BIOCHEMISTRY

LIN28B Promotes Colon Cancer Progression and Metastasis

(2011) C. E. King et al.   CANCER RESEARCH

Molecular Basis for Interaction of let-7 MicroRNAs with Lin28

(2011) Yunsun Nam et al.   CELL

Lin28A and Lin28B Inhibit let-7 MicroRNA Biogenesis by Distinct Mechanisms

(2011) Elena Piskounova et al.   CELL

The Lin28/let-7 Axis Regulates Glucose Metabolism

(2011) Hao Zhu et al.   CELL

Recent progress in the study of the genetics of height

(2011) Guillaume Lettre   HUMAN GENETICS

RNA-binding protein LIN28 is a marker for testicular germ cell tumors

(2011) Dengfeng Cao et al.   HUMAN PATHOLOGY

From unwinding to clamping — the DEAD box RNA helicase family

(2011) Patrick Linder et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

LIN-28 co-transcriptionally binds primary let-7 to regulate miRNA maturation in Caenorhabditis elegans

(2011) Priscilla M Van Wynsberghe et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Importance of the NCp7-like domain in the recognition of pre-let-7g by the pluripotency factor Lin28

(2011) Alexandre Desjardins et al.   NUCLEIC ACIDS RESEARCH

Evidence that Lin28 stimulates translation by recruiting RNA helicase A to polysomes

(2011) J. Jin et al.   NUCLEIC ACIDS RESEARCH

LIN28B fosters colon cancer migration, invasion and transformation through let-7-dependent and -independent mechanisms

(2011) C E King et al.   ONCOGENE

Genome-Wide Studies Reveal That Lin28 Enhances the Translation of Genes Important for Growth and Survival of Human Embryonic Stem Cells

(2011) Shuping Peng et al.   STEM CELLS

Double-Negative Feedback Loop between Reprogramming Factor LIN28 and microRNA let-7 Regulates Aldehyde Dehydrogenase 1-Positive Cancer Stem Cells

(2010) X. Yang et al.   CANCER RESEARCH

Lin28: A MicroRNA Regulator with a Macro Role

(2010) Srinivas R. Viswanathan et al.   CELL

LIN28 alters cell fate succession and acts independently of the let-7 microRNA during neurogliogenesis in vitro

(2010) E. Balzer et al.   DEVELOPMENT

Emerging paradigms of regulated microRNA processing

(2010) M. A. Newman et al.   GENES & DEVELOPMENT

Identification of MicroRNAs Regulating Reprogramming FactorLIN28in Embryonic Stem Cells and Cancer Cells

(2010) Xiaomin Zhong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Yin-Yang balancing act of the lin28/let-7 link in tumorigenesis

(2010) Junfang Ji et al.   JOURNAL OF HEPATOLOGY

Opposing microRNA families regulate self-renewal in mouse embryonic stem cells

(2010) Collin Melton et al.   NATURE

Lin28a transgenic mice manifest size and puberty phenotypes identified in human genetic association studies

(2010) Hao Zhu et al.   NATURE GENETICS

Antagonistic role of hnRNP A1 and KSRP in the regulation of let-7a biogenesis

(2010) Gracjan Michlewski et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Pluripotency factors Lin28 and Oct4 identify a sub-population of stem cell-like cells in ovarian cancer

(2010) S Peng et al.   ONCOGENE

An Epigenetic Switch Involving NF-κB, Lin28, Let-7 MicroRNA, and IL6 Links Inflammation to Cell Transformation

(2009) Dimitrios Iliopoulos et al.   CELL

Topology and Regulation of the Human eIF4A/4G/4H Helicase Complex in Translation Initiation

(2009) Assen Marintchev et al.   CELL

TUT4 in Concert with Lin28 Suppresses MicroRNA Biogenesis through Pre-MicroRNA Uridylation

(2009) Inha Heo et al.   CELL

Raf kinase inhibitory protein suppresses a metastasis signalling cascade involving LIN28 and let-7

(2009) Surabhi Dangi-Garimella et al.   EMBO JOURNAL

Pluripotent factor lin-28 and its homologue lin-28b in epithelial ovarian cancer and their associations with disease outcomes and expression of let-7a and IGF-II

(2009) Lingeng Lu et al.   EUROPEAN JOURNAL OF CANCER

The RNA-binding protein KSRP promotes the biogenesis of a subset of microRNAs

(2009) Michele Trabucchi et al.   NATURE

Direct cell reprogramming is a stochastic process amenable to acceleration

(2009) Jacob Hanna et al.   NATURE

Lin28 promotes transformation and is associated with advanced human malignancies

(2009) Srinivas R Viswanathan et al.   NATURE GENETICS

Lin28 recruits the TUTase Zcchc11 to inhibit let-7 maturation in mouse embryonic stem cells

(2009) John P Hagan et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

LIN-28 and the poly(U) polymerase PUP-2 regulate let-7 microRNA processing in Caenorhabditis elegans

(2009) Nicolas J Lehrbach et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Histone H2a mRNA interacts with Lin28 and contains a Lin28-dependent posttranscriptional regulatory element

(2009) Bingsen Xu et al.   NUCLEIC ACIDS RESEARCH

Lin28-mediated post-transcriptional regulation of Oct4 expression in human embryonic stem cells

(2009) Caihong Qiu et al.   NUCLEIC ACIDS RESEARCH

RNA helicase A modulates translation of HIV-1 and infectivity of progeny virions

(2009) Cheryl Bolinger et al.   NUCLEIC ACIDS RESEARCH

Lin-28B transactivation is necessary for Myc-mediated let-7 repression and proliferation

(2009) T.-C. Chang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lin28 modulates cell growth and associates with a subset of cell cycle regulator mRNAs in mouse embryonic stem cells

(2009) B. Xu et al.   RNA

Nuclear networking fashions pre-messenger RNA and primary microRNA transcripts for function

(2009) Jan M. Pawlicki et al.   TRENDS IN CELL BIOLOGY

Regulation of Pluripotency and Reprogramming by Transcription Factors

(2008) Duanqing Pei   JOURNAL OF BIOLOGICAL CHEMISTRY

Determinants of MicroRNA Processing Inhibition by the Developmentally Regulated RNA-binding Protein Lin28

(2008) Elena Piskounova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lin28 Mediates the Terminal Uridylation of let-7 Precursor MicroRNA

(2008) Inha Heo et al.   MOLECULAR CELL

A feedback loop comprising lin-28 and let-7 controls pre-let-7 maturation during neural stem-cell commitment

(2008) Agnieszka Rybak et al.   NATURE CELL BIOLOGY

Primary microRNA transcripts are processed co-transcriptionally

(2008) Mariangela Morlando et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Lin-28 interaction with the Let-7 precursor loop mediates regulated microRNA processing

(2008) M. A. Newman et al.   RNA

Selective Blockade of MicroRNA Processing by Lin28

(2008) S. R. Viswanathan et al.   SCIENCE

Genetic Analysis of the Role of the Reprogramming GeneLIN-28in Human Embryonic Stem Cells

(2008) Henia Darr et al.   STEM CELLS

The let-7 family of microRNAs

(2008) Sarah Roush et al.   TRENDS IN CELL BIOLOGY

let-7 microRNAs in development, stem cells and cancer

(2008) Ingo Büssing et al.   TRENDS IN MOLECULAR MEDICINE