Regulation of nonsense-mediated mRNA decay

Hypoxic regulation of mRNA expression

(2011) Lawrence Gardner et al.   CELL CYCLE

Nonsense-mediated mRNA decay (NMD) in animal embryogenesis: to die or not to die, that is the question

(2011) Jungwook Hwang et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

The nonsense-mediated mRNA decay SMG-1 kinase is regulated by large-scale conformational changes controlled by SMG-8

(2011) E. Arias-Palomo et al.   GENES & DEVELOPMENT

Cross Talk between Immunoglobulin Heavy-Chain Transcription and RNA Surveillance during B Cell Development

(2011) A. Tinguely et al.   MOLECULAR AND CELLULAR BIOLOGY

Inhibition of Nonsense-Mediated RNA Decay by the Tumor Microenvironment Promotes Tumorigenesis

(2011) D. Wang et al.   MOLECULAR AND CELLULAR BIOLOGY

Stay Tuned: miRNA Expression and Nonsense-Mediated Decay in Brain Development

(2011) Andreas E. Kulozik   MOLECULAR CELL

RNA Homeostasis Governed by Cell Type-Specific and Branched Feedback Loops Acting on NMD

(2011) Lulu Huang et al.   MOLECULAR CELL

Identification of a MicroRNA that Activates Gene Expression by Repressing Nonsense-Mediated RNA Decay

(2011) Ivone G. Bruno et al.   MOLECULAR CELL

Dhx34 and Nbas function in the NMD pathway and are required for embryonic development in zebrafish

(2011) Corina Anastasaki et al.   NUCLEIC ACIDS RESEARCH

Perturbation of thymocyte development in nonsense-mediated decay (NMD)-deficient mice

(2011) P. A. Frischmeyer-Guerrerio et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A nonconservative amino acid change in the UPF3B gene in a patient with schizophrenia

(2011) Paulina Szyszka et al.   PSYCHIATRIC GENETICS

Drosophila Upf1 and Upf2 loss of function inhibits cell growth and causes animal death in a Upf3-independent manner

(2011) P. Avery et al.   RNA

Autoregulation of the nonsense-mediated mRNA decay pathway in human cells

(2011) H. Yepiskoposyan et al.   RNA

NMD: RNA biology meets human genetic medicine

(2010) Madhuri Bhuvanagiri et al.   BIOCHEMICAL JOURNAL

Nonsense-mediated mRNA decay and development: shoot the messenger to survive?

(2010) Marta Vicente-Crespo et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Cutting the nonsense: the degradation of PTC-containing mRNAs

(2010) Pamela Nicholson et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

SMG6 interacts with the exon junction complex via two conserved EJC-binding motifs (EBMs) required for nonsense-mediated mRNA decay

(2010) I. Kashima et al.   GENES & DEVELOPMENT

Multiple RNA Surveillance Mechanisms Cooperate to Reduce the Amount of Nonfunctional Ig  Transcripts

(2010) G. Chemin et al.   JOURNAL OF IMMUNOLOGY

Nonsense-Mediated RNA Decay Regulation by Cellular Stress: Implications for Tumorigenesis

(2010) L. B. Gardner   MOLECULAR CANCER RESEARCH

Erratum: A novel frameshift mutation in UPF3B identified in brothers affected with childhood onset schizophrenia and autism spectrum disorders

(2010) A M Addington et al.   MOLECULAR PSYCHIATRY

Phenotypic robustness conferred by apparently redundant transcriptional enhancers

(2010) Nicolás Frankel et al.   NATURE

The widespread regulation of microRNA biogenesis, function and decay

(2010) Jacek Krol et al.   NATURE REVIEWS GENETICS

Characterization of SMG-9, an essential component of the nonsense-mediated mRNA decay SMG1C complex

(2010) Israel S. Fernández et al.   NUCLEIC ACIDS RESEARCH

UPF2 Is a Critical Regulator of Liver Development, Function and Regeneration

(2010) Lina A. Thoren et al.   PLoS One

Insights into the recruitment of the NMD machinery from the crystal structure of a core EJC-UPF3b complex.

(2010) G. Buchwald et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Smg1 is required for embryogenesis and regulates diverse genes via alternative splicing coupled to nonsense-mediated mRNA decay

(2010) D. R. McIlwain et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Robustness and Evolvability

(2010) Joanna Masel et al.   TRENDS IN GENETICS

Disassembly of Exon Junction Complexes by PYM

(2009) Niels H. Gehring et al.   CELL

Nonsense-mediated mRNA decay in human cells: mechanistic insights, functions beyond quality control and the double-life of NMD factors

(2009) Pamela Nicholson et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Unusual bipartite mode of interaction between the nonsense-mediated decay factors, UPF1 and UPF2

(2009) Marcello Clerici et al.   EMBO JOURNAL

SMG-8 and SMG-9, two novel subunits of the SMG-1 complex, regulate remodeling of the mRNA surveillance complex during nonsense-mediated mRNA decay

(2009) A. Yamashita et al.   GENES & DEVELOPMENT

Genome-wide mapping of alternative splicing in Arabidopsis thaliana

(2009) S. A. Filichkin et al.   GENOME RESEARCH

Nonsense-Mediated mRNA Decay Effectors Are Essential for Zebrafish Embryonic Development and Survival

(2009) N. Wittkopp et al.   MOLECULAR AND CELLULAR BIOLOGY

Mutations of the UPF3B gene, which encodes a protein widely expressed in neurons, are associated with nonspecific mental retardation with or without autism

(2009) F Laumonnier et al.   MOLECULAR PSYCHIATRY

A UPF3-mediated regulatory switch that maintains RNA surveillance

(2009) Wai-Kin Chan et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Frame-disrupting mutations elicit pre-mRNA accumulation independently of frame disruption

(2009) J. Saadi Imam et al.   NUCLEIC ACIDS RESEARCH

The upstream open reading frame of the Arabidopsis AtMHX gene has a strong impact on transcript accumulation through the nonsense-mediated mRNA decay pathway

(2009) Helen Saul et al.   PLANT JOURNAL

Global analysis of alternative splicing uncovers developmental regulation of nonsense-mediated decay in C. elegans

(2009) S. Barberan-Soler et al.   RNA

The Hierarchy of Exon-Junction Complex Assembly by the Spliceosome Explains Key Features of Mammalian Nonsense-Mediated mRNA Decay

(2009) Niels H. Gehring et al.   PLOS BIOLOGY

Genome-Wide Identification of Alternative Splice Forms Down-Regulated by Nonsense-Mediated mRNA Decay in Drosophila

(2009) Kasper Daniel Hansen et al.   PLoS Genetics

High resolution transcriptome maps for wild-type and nonsense-mediated decay-defective Caenorhabditis elegans

(2009) Arun K Ramani et al.   GENOME BIOLOGY

Competency for Nonsense-Mediated Reduction in Collagen X mRNA Is Specified by the 3′ UTR and Corresponds to the Position of Mutations in Schmid Metaphyseal Chondrodysplasia

(2008) Jacqueline T. Tan et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Recognition of nonsense mRNA: towards a unified model: Figure 1

(2008) Oliver Mühlemann   BIOCHEMICAL SOCIETY TRANSACTIONS

Comparison of nonsense-mediated mRNA decay efficiency in various murine tissues

(2008) Almoutassem B Zetoune et al.   BMC GENETICS

Upf1 Phosphorylation Triggers Translational Repression during Nonsense-Mediated mRNA Decay

(2008) Olaf Isken et al.   CELL

Inter-kingdom conservation of mechanism of nonsense-mediated mRNA decay

(2008) Zoltán Kerényi et al.   EMBO JOURNAL

Interactions between UPF1, eRFs, PABP and the exon junction complex suggest an integrated model for mammalian NMD pathways

(2008) Pavel V Ivanov et al.   EMBO JOURNAL

NMD is essential for hematopoietic stem and progenitor cells and for eliminating by-products of programmed DNA rearrangements

(2008) J. Weischenfeldt et al.   GENES & DEVELOPMENT

SMD and NMD are competitive pathways that contribute to myogenesis: effects on PAX3 and myogenin mRNAs

(2008) C. Gong et al.   GENES & DEVELOPMENT

Nonsense Codons Trigger an RNA Partitioning Shift

(2008) Angela D. Bhalla et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Protective Role for the Human SMG-1 Kinase against Tumor Necrosis Factor-α-induced Apoptosis

(2008) Vasco Oliveira et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of Multiple Core Spliceosomal Proteins by Alternative Splicing-Coupled Nonsense-Mediated mRNA Decay

(2008) A. L. Saltzman et al.   MOLECULAR AND CELLULAR BIOLOGY

Hypoxic Inhibition of Nonsense-Mediated RNA Decay Regulates Gene Expression and the Integrated Stress Response

(2008) L. B. Gardner   MOLECULAR AND CELLULAR BIOLOGY

SMG6 promotes endonucleolytic cleavage of nonsense mRNA in human cells

(2008) Andrea B Eberle et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

hSMG-1 and ATM sequentially and independently regulate the G1 checkpoint during oxidative stress

(2008) S C Gehen et al.   ONCOGENE

Upf1 potentially serves as a RING-related E3 ubiquitin ligase via its association with Upf3 in yeast

(2008) S. Takahashi et al.   RNA

Alternative splicing resulting in nonsense-mediated mRNA decay: what is the meaning of nonsense?

(2008) Nicholas J. McGlincy et al.   TRENDS IN BIOCHEMICAL SCIENCES

A Competition between Stimulators and Antagonists of Upf Complex Recruitment Governs Human Nonsense-Mediated mRNA Decay

(2008) Guramrit Singh et al.   PLOS BIOLOGY

Posttranscriptional Gene Regulation by Spatial Rearrangement of the 3′ Untranslated Region

(2008) Andrea B Eberle et al.   PLOS BIOLOGY