Review
Rheumatology
Frederic Meyer, Delphine Weil-Verhoeven, Clement Prati, Daniel Wendling, Frank Verhoeven
Summary: The use of biologic treatments in solid-organ transplant recipients poses risks of complications, such as infections, malignancies, and acute graft rejections. Further comparative studies are needed to evaluate the safety of biological treatments in transplanted patients.
SEMINARS IN ARTHRITIS AND RHEUMATISM
(2021)
Article
Immunology
Hannah N. Imlay, Daniel R. Kaul
Summary: Until recently, available drugs for CMV prevention and treatment in transplant patients have been limited by toxicity and resistance issues, with letermovir being the first new drug approved for CMV prevention since 2003. The efficacy of letermovir in treating established CMV infection or disease remains largely unstudied, while the investigational agent maribavir shows promise as a preemptive treatment option with unique mechanisms of action. Ongoing studies will define the efficacy of these drugs in patients with refractory or resistant CMV disease.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Microbiology
Arnau Monforte, Ibai Los-Arcos, Maria Teresa Martin-Gomez, David Campany-Herrero, Judith Sacanell, Cristina Berastegui, Ester Marquez-Algaba, Abiu Sempere, Xavier Nuvials, Maria Deu, Lluis Castells, Francesc Moreso, Carles Bravo, Joan Gavalda, Oscar Len
Summary: We describe 53 solid organ transplant recipients treated with isavuconazole for fungal infections. There is scarce data of its use in solid organ transplant recipients, where interactions with calcineurin inhibitors and mTOR and adverse drug events have limited the use of other triazoles. To the best of our knowledge, this is the first article describing the safety regarding adverse events and drug interactions of isavuconazole for the treatment of fungal infections in a cohort of solid organ transplant recipients. Also, although this is a noncomparative study, we report some real world effectivity data of these patients, including treatment of non-Aspergillus fungal infections.
MICROBIOLOGY SPECTRUM
(2022)
Review
Oncology
Rosario Mazzola, Francesco Cuccia, Alessandro Bertani, Slavisa Tubin, Pier Giulio Conaldi, Stefanie Corradini, Maria Tolia, Markus Guba, Filippo Alongi
Summary: Radiotherapy in cancer patients with prior organ transplants poses challenges due to potential effects on immunosuppressive therapy and organ tolerance. This systematic review aims to assess the safety and efficacy of radiotherapy in these patients, focusing on modern treatment techniques.
Article
Medicine, General & Internal
Seyed M. Hosseini-Moghaddam, Bin Luo, Sarah E. Bota, Shahid Husain, Michael S. Silverman, Nick Daneman, Kevin A. Brown, J. Michael Paterson
Summary: This study reveals an increasing trend of CDI in annual cohorts of SOT recipients. Posttransplant CDI is associated with mortality, and late-onset CDI poses a greater risk of death compared to early-onset CDI.
Review
Virology
S. Reshwan K. Malahe, Jeroen J. A. van Kampen, Olivier C. C. Manintveld, Rogier A. S. Hoek, Caroline M. M. den Hoed, Carla C. C. Baan, Marcia M. L. Kho, Georges M. G. M. Verjans
Summary: Solid organ transplant recipients (SOTRs) face a high risk of human herpesvirus (HHV)-related morbidity and mortality due to immunosuppressive therapy. We aim to increase awareness of the HHV disease burden in SOTRs by providing an overview of current prevention and management strategies from the literature and guidelines. We discuss challenges in prevention, treatment, and future perspectives.
Article
Oncology
Tomohiro Tanaka, Charles F. Lynch, Kelly J. Yu, Bozena M. Morawski, Mei-Chin Hsieh, Georgetta Alverson, April A. Austin, Yun Zeng, Eric A. Engels
Summary: The incidence of pancreatic cancer is higher in solid organ transplant recipients, particularly in liver transplant recipients. Compared with the general population, pancreatic cancer is more commonly diagnosed in transplant recipients, especially in cases arising in the head of the pancreas and those diagnosed at localized stage. Risk factors for pancreatic cancer in transplant recipients are consistent with those in the general population, including male sex, older age, non-O blood type, and history of diabetes.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Review
Medicine, General & Internal
Apostolos Prionas, Charles Craddock, Vassilios Papalois
Summary: The study compared enhanced recovery after surgery (ERAS) with traditional perioperative care for renal transplant recipients. Results showed that ERAS decreased urological complications, shortened length of stay, and did not increase unplanned readmission rates.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Immunology
Sara Belga, Clayton MacDonald, Diana Chiang, Dima Kabbani, Soroush Shojai, Juan G. Abraldes, Carlos Cervera
Summary: The study found that patients exposed to CMV at transplantation have a higher risk of posttransplant thrombotic events, independent of pretransplant cardiovascular risk factors and thrombotic events.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Surgery
Molly Hayes, Craig L. K. Boge, Anna Sharova, Daniel Vader, Marina Mitrou, Despoina M. Galetaki, Yun Li, Kevin J. Downes
Summary: Toxicities are common with VGCV prophylaxis in pediatric SOT recipients, including kidney injury and neutropenia.
AMERICAN JOURNAL OF TRANSPLANTATION
(2022)
Article
Hematology
Zeinab Afify, Manuela Orjuela-Grimm, Christine Moore Smith, Mansi Dalal, James B. Ford, Pallavi Pillai, Joanna M. Robles, Sonika Reddy, Sarah McCormack, Matthew J. Ehrhardt, Tonya Ureda, Warren Alperstein, Holly Edington, Tamara P. Miller, Jeremy D. Rubinstein, Madison Kavanaugh, Andrew J. Bukowinski, Erika Friehling, Julie M. Rivers, Karen M. Chisholm, Lianna J. Marks, Clinton C. Mason
Summary: PSOT-BL is a clinically aggressive malignancy and a rare form of PTLD. Most patients developed PSOT-BL more than 2 years after transplantation. Heart and liver were the most frequently transplanted organs. The outcomes of intensive regimens for PSOT-BL patients are comparable to immunocompetent children with BL. Multi-institutional collaboration is important for collecting prospective data to determine the optimal treatment regimen.
BRITISH JOURNAL OF HAEMATOLOGY
(2023)
Review
Urology & Nephrology
Alexander C. Wiseman
Summary: Chronic kidney disease after solid organ transplant is common, with varied causes among different types of transplants. Kidney transplantation benefits solid organ transplant recipients with advanced CKD, but they face higher mortality rates both while waitlisted and after transplant. Recent policies aim to improve candidate identification and prioritization for kidney transplants, with future research focusing on predictive factors and strategies to preserve kidney function in this unique patient population.
AMERICAN JOURNAL OF KIDNEY DISEASES
(2022)
Review
Peripheral Vascular Disease
Gilad Hamdani, Mark M. Mitsnefes
Summary: The current literature on hypertension (HTN) following pediatric solid organ transplant (SOTx) was reviewed, including definition, prevalence, risk factors, outcomes, and treatment. Several new guidelines for pediatric HTN have been published, but no specific recommendations for SOTx recipients. HTN is highly prevalent, yet underdiagnosed and undertreated in kidney transplant recipients, especially with ambulatory blood pressure monitoring. Little data is available regarding its prevalence in other SOTx recipients. HTN in this population is multifactorial and associated with pre-transplant HTN, demographic factors, weight status, and immunosuppression protocol. HTN is associated with subclinical cardiovascular (CV) end-organ damage, but no recent data on long-term outcomes are available. There are no updated recommendations for the optimal management of HTN in this population.
CURRENT HYPERTENSION REPORTS
(2023)
Review
Immunology
Mauro Vigano, Marta Beretta, Marta Lepore, Raffaele Abete, Simone Vasilij Benatti, Maria Vittoria Grassini, Stefania Camagni, Greta Chiodini, Simone Vargiu, Claudia Vittori, Marco Iachini, Amedeo Terzi, Flavia Neri, Domenico Pinelli, Valeria Casotti, Fabiano Di Marco, Piero Ruggenenti, Marco Rizzi, Michele Colledan, Stefano Fagiuoli
Summary: Prevention of infections is crucial in solid organ transplant candidates and recipients. Vaccination is an important measure, however, the vaccine response is reduced, especially in the early post-transplant period or after rejection treatment.
Article
Virology
Zachary A. Yetmar, Joseph D. Yao, Raymund R. Razonable
Summary: Neutralizing antispike monoclonal antibody therapies are effective in preventing COVID-19 hospitalization, but the impact of SARS-CoV-2 variants with spike protein mutations on clinical outcomes is not well understood. A study on solid organ transplant recipients treated with antispike monoclonal antibody revealed common spike codon mutations, but these mutations did not predict the need for hospitalization after treatment.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Surgery
Hege K. Pihlstrom, Geir Mjoen, Soren Mucha, Andre Franke, Alan Jardine, Bengt Fellstrom, Dag Olav Dahle, Hallvard Holdaas, Espen Melum
AMERICAN JOURNAL OF TRANSPLANTATION
(2019)
Review
Cardiac & Cardiovascular Systems
Jennifer Susan Lees, Fiona A. Chapman, Miles D. Witham, Alan G. Jardine, Patrick B. Mark
Article
Surgery
Caragh P. Stapleton, Andreas Heinzel, Weihua Guan, Peter J. van der Most, Jessica van Setten, Graham M. Lord, Brendan J. Keating, Ajay K. Israni, Martin H. de Borst, Stephan J. L. Bakker, Harold Snieder, Michael E. Weale, Florence Delaney, Maria P. Hernandez-Fuentes, Roman Reindl-Schwaighofer, Rainer Oberbauer, Pamala A. Jacobson, Patrick B. Mark, Fiona A. Chapman, Paul J. Phelan, Claire Kennedy, Donal Sexton, Susan Murray, Alan Jardine, Jamie P. Traynor, Amy Jayne McKnight, Alexander P. McKnight, Laura J. Smyth, William S. Oetting, Arthur J. Matas, Roslyn B. Mannon, David P. Schladt, David N. Ikle, Gianpiero L. Cavalleri, Peter J. Conlon, Christopher Franklin, Irene Rebollo-Mesa, Jennifer Mollon, Esperanza Perucha, Richard Borrows, Catherine Byrne, Brendan Clarke, Menna Clatworthy, John Feehally, Susan Fuggle, Sarah A. Gagliano, Sian Griffin, Abdul Hammad, Robert Higgins, Mary Keogan, Timothy Leach, Iain MacPhee, James Marsh, Peter Maxwell, William McKane, Adam McLean, Charles Newstead, Titus Augustine, Steve Powis, Peter Rowe, Neil Sheerin, Ellen Solomon, Henry Stephens, Raj Thuraisingham, Richard Trembath, Peter Topham, Steven H. Sacks, Peter Conlon, Gerhard Opelz, Nicole Soranzo, J. Michael Cecka, John Connett, Fernando G. Cosio, Robert Gaston, Sita Gourishankar, Joseph P. Grande, Lawrence Hunsicker, Bertram Kasiske, David Rush
AMERICAN JOURNAL OF TRANSPLANTATION
(2019)
Article
Urology & Nephrology
Sophie Girerd, Nicolas Girerd, Luc Frimat, Hallvard Holdaas, Alan G. Jardine, Roland E. Schmieder, Bengt Fellstrom, Nicla Settembre, Sergei Malikov, Patrick Rossignol, Faiez Zannad
CLINICAL KIDNEY JOURNAL
(2020)
Review
Cardiac & Cardiovascular Systems
Mark J. Sarnak, Kerstin Amann, Sripal Bangalore, Joao L. Cavalcante, David M. Charytan, Jonathan C. Craig, John S. Gill, Mark A. Hlatky, Alan G. Jardine, Ulf Landmesser, L. Kristin Newby, Charles A. Herzog, Michael Cheung, David C. Wheeler, Wolfgang C. Winkelmayer, Thomas H. Marwick
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2019)
Article
Urology & Nephrology
Thomas H. Marwick, Kerstin Amann, Sripal Bangalore, Joao L. Cavalcante, David M. Charytan, Jonathan C. Craig, John S. Gill, Mark A. Hlatky, Alan G. Jardine, Ulf Landmesser, L. Kristin Newby, Charles A. Herzog, Michael Cheung, David C. Wheeler, Wolfgang C. Winkelmayer, Mark J. Sarnak, Debasish Banerjee, Carlo Briguori, Tara I. Chang, Chien-Liang Chen, Christopher R. deFilippi, Xiaoqiang Ding, Charles J. Ferro, Jagbir Gill, Mario Gossl, Nicole M. Isbel, Hideki Ishii, Meg J. Jardine, Philip A. Kalra, Guenther Laufer, Krista L. Lentine, Kevin W. Lobdell, Charmaine E. Lok, Gerard M. London, Jolanta Malyszko, Patrick B. Mark, Mohamed Marwan, Yuxin Nie, Patrick S. Parfrey, Roberto Pecoits-Filho, Helen Pilmore, Wajeh Y. Qunibi, Paolo Raggi, Marcello Rattazzi, Patrick Rossignol, Josiah Ruturi, Charumathi Sabanayagam, Catherine M. Shanahan, Gautam R. Shroff, Rukshana Shroff, Angela C. Webster, Daniel E. Weiner, Simon Winther, Alexander C. Wiseman, Anthony Yip, Alexander Zarbock
KIDNEY INTERNATIONAL
(2019)
Article
Urology & Nephrology
Elaine Rutherford, Sheila Ireland, Kenneth Mangion, Graham A. Stewart, Mark S. MacGregor, Giles Roditi, Rosemary Woodward, Stephen J. Gandy, J. Graeme Houston, Alan G. Jardine, Petra Rauchhaus, Miles D. Witham, Patrick B. Mark, Allan D. Struthers
Summary: In hemodialysis patients, 12 months of treatment with allopurinol did not regress LVMI. Allopurinol also showed no significant effects on blood pressure, flow-mediated dilation, augmentation indices, or pulse wave velocity.
KIDNEY INTERNATIONAL REPORTS
(2021)
Article
Cardiac & Cardiovascular Systems
Glenn M. Chertow, Pablo E. Pergola, Rajiv Agarwal, Geoffrey A. Block, Youssef M. K. Farag, Alan G. Jardine, Mark J. Koury, Wenli Luo, Zeeshan Khawaja, Eldrin F. Lewis, Kunihiro Matsushita, Peter A. McCullough, Patrick S. Parfrey, Janet Wittes, Kimberly A. Walters, Carol Tseng, Tim Lin, Mark J. Sarnak, Dennis L. Vargo, Wolfgang C. Winkelmayer, Kai-Uwe Eckardt
Summary: Vadadustat, an investigational oral hypoxia-inducible factor prolyl-hydroxylase inhibitor, is being studied for its safety and efficacy in managing anemia in non-dialysis-dependent chronic kidney disease patients. The trials will evaluate the change in hemoglobin levels between vadadustat and darbepoetin alfa treatments in different anemia patients, with similar demographics and baseline characteristics among participants.
AMERICAN HEART JOURNAL
(2021)
Article
Surgery
Jennifer S. Lees, Alastair J. Rankin, Keith A. Gillis, Luke Y. Zhu, Kenneth Mangion, Elaine Rutherford, Giles H. Roditi, Miles D. Witham, Donna Chantler, Maurizio Panarelli, Alan G. Jardine, Patrick B. Mark
Summary: In this study, vitamin K supplementation did not reduce vascular stiffness or calcification in KTR over 1 year. Improving vascular health in KTR is likely to require a multifaceted approach.
AMERICAN JOURNAL OF TRANSPLANTATION
(2021)
Article
Medicine, General & Internal
Glenn M. Chertow, Pablo E. Pergola, Youssef M. K. Farag, Rajiv Agarwal, Susan Arnold, Gabriel Bako, Geoffrey A. Block, Steven Burke, Fausto P. Castillo, Alan G. Jardine, Zeeshan Khawaja, Mark J. Koury, Eldrin F. Lewis, Tim Lin, Wenli Luo, Bradley J. Maroni, Kunihiro Matsushita, Peter A. McCullough, Patrick S. Parfrey, Prabir Roy-Chaudhury, Mark J. Sarnak, Amit Sharma, Bruce Spinowitz, Carol Tseng, James Tumlin, Dennis L. Vargo, Kimberly A. Walters, Wolfgang C. Winkelmayer, Janet Wittes, Kai-Uwe Eckardt
Summary: Vadadustat, compared to darbepoetin alfa, met the prespecified noninferiority criterion for hematologic efficacy but not for cardiovascular safety in patients with NDD-CKD.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Article
Medicine, General & Internal
Kai-Uwe Eckardt, Rajiv Agarwal, Ahmad Aswad, Ahmed Awad, Geoffrey A. Block, Marcelo R. Bacci, Youssef M. K. Farag, Steven Fishbane, Harold Hubert, Alan Jardine, Zeeshan Khawaja, Mark J. Koury, Bradley J. Maroni, Kunihiro Matsushita, Peter A. McCullough, Eldrin F. Lewis, Wenli Luo, Patrick S. Parfrey, Pablo Pergola, Mark J. Sarnak, Bruce Spinowitz, James Tumlin, Dennis L. Vargo, Kimberly A. Walters, Wolfgang C. Winkelmayer, Janet Wittes, Rafal Zwiech, Glenn M. Chertow
Summary: Vadadustat, an oral prolyl hydroxylase inhibitor, was found to be noninferior to darbepoetin alfa in terms of cardiovascular safety and hemoglobin concentration in anemia patients with CKD undergoing dialysis, based on two phase 3 trials.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Article
Urology & Nephrology
Peter C. Thomson, Patrick B. Mark, Michele Robertson, Claire White, Stefan D. Anker, Sunil Bhandari, Kenneth Farrington, Alan G. Jardine, Philip A. Kalra, John McMurray, Donal Reddan, David C. Wheeler, Christopher G. Winearls, Ian Ford, Iain C. Macdougall
Summary: This study analyzed the association between anemia treatment and vascular access thrombosis (VAT) in dialysis patients. The results showed that proactive IV iron therapy was not associated with an increased risk of VAT. Diabetic kidney disease, AVG use, diuretic use, female sex, and previous/current smoker were independently associated with a higher risk of VAT, while the use of angiotensin receptor blockers was associated with a lower risk.
KIDNEY INTERNATIONAL REPORTS
(2022)
Article
Cardiac & Cardiovascular Systems
Jennifer Susan Lees, Kenneth Mangion, Elaine Rutherford, Miles D. Witham, Rosemary Woodward, Giles Roditi, Tracey Hopkins, Katriona Brooksbank, Alan G. Jardine, Patrick B. Mark
Article
Urology & Nephrology
Emma O'Lone, Andrea K. Viecelli, Jonathan C. Craig, Allison Tong, Benedicte Sautenet, William G. Herrington, Charles A. Herzog, Tazeen H. Jafar, Meg Jardine, Vera Krane, Adeera Levin, Jolanta Malyszko, Michael Rocco, Giovanni Strippoli, Marcello Tonelli, Angela Yee Moon Wang, Christoph Wanner, Faiez Zannad, Wolfgang C. Winkelmayer, David C. Wheeler
AMERICAN JOURNAL OF KIDNEY DISEASES
(2020)
Article
Medicine, Research & Experimental
David de Gonzalo-Calvo, Pablo Martinez-Camblor, Christian Baer, Kevin Duarte, Nicolas Girerd, Bengt Fellstrom, Roland E. Schmieder, Alan G. Jardine, Ziad A. Massy, Hallvard Holdaas, Patrick Rossignol, Faiez Zannad, Thomas Thum
