Emerging Therapies: Pleiotropic Multi-target Drugs to Treat Stroke Victims

Comparison of the post-embolization effects of tissue-plasminogen activator and simvastatin on neurological outcome in a clinically relevant rat model of acute ischemic stroke

(2010) Kama Z. Guluma et al.   BRAIN RESEARCH

A new embolus injection method to evaluate intracerebral hemorrhage in New Zealand white rabbits

(2010) Paul A. Lapchak   BRAIN RESEARCH

Executive Summary: Heart Disease and Stroke Statistics—2010 Update

(2010) et al.   CIRCULATION

Building a Tiered Approach to In Vitro Predictive Toxicity Screening: A Focus on Assays with In Vivo Relevance

(2010) James McKim Jr.   COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING

Neuroprotective and neurotrophic curcuminoids to treat stroke: a translational perspective

(2010) Paul A Lapchak   EXPERT OPINION ON INVESTIGATIONAL DRUGS

A critical assessment of edaravone acute ischemic stroke efficacy trials: is edaravone an effective neuroprotective therapy?

(2010) Paul A Lapchak   EXPERT OPINION ON PHARMACOTHERAPY

Reperfusion and Outcomes in Penumbra Vs. Systemic Tissue Plasminogen Activator Clinical Trials

(2010) Andrei V. Alexandrov et al.   International Journal of Stroke

Preclinical Drug Evaluation for Combination Therapy in Acute Stroke Using Systematic Review, Meta-Analysis, and Subsequent Experimental Testing

(2010) Victoria E O'Collins et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Trends in thrombolytic use for ischemic stroke in the United States

(2010) Margaret C. Fang et al.   Journal of Hospital Medicine

Delayed treatment with a novel neurotrophic compound reduces behavioral deficits in rabbit ischemic stroke

(2010) Paul A. Lapchak et al.   JOURNAL OF NEUROCHEMISTRY

Stroke Location and Brain Function in an Embolic Rabbit Stroke Model

(2010) Aliza T. Brown et al.   JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY

Time to treatment with intravenous alteplase and outcome in stroke: an updated pooled analysis of ECASS, ATLANTIS, NINDS, and EPITHET trials

(2010) Kennedy R Lees et al.   LANCET

The Science of Stroke: Mechanisms in Search of Treatments

(2010) Michael A. Moskowitz et al.   NEURON

New Approaches to Neuroprotective Drug Development

(2010) M. Fisher   STROKE

Low Rates of Acute Recanalization With Intravenous Recombinant Tissue Plasminogen Activator in Ischemic Stroke

(2010) Rohit Bhatia et al.   STROKE

Reperfusion Therapies for Acute Ischemic Stroke: Current Pharmacological and Mechanical Approaches

(2010) C. A. Molina   STROKE

CeeTox™ Analysis of CNB-001 a Novel Curcumin-Based Neurotrophic/Neuroprotective Lead Compound to Treat Stroke: Comparison with NXY-059 and Radicut

(2010) Paul A. Lapchak et al.   Translational Stroke Research

Translational Stroke Research Using a Rabbit Embolic Stroke Model: A Correlative Analysis Hypothesis for Novel Therapy Development

(2010) Paul A. Lapchak   Translational Stroke Research

Transcranial near infrared laser treatment (NILT) increases cortical adenosine-5′-triphosphate (ATP) content following embolic strokes in rabbits

(2009) Paul A. Lapchak et al.   BRAIN RESEARCH

Effects of NXY-059 in experimental stroke: an individual animal meta-analysis

(2009) PMW Bath et al.   BRITISH JOURNAL OF PHARMACOLOGY

Heart Disease and Stroke Statistics—2009 Update

(2009) et al.   CIRCULATION

Heart Disease and Stroke Statistics—2010 Update

(2009) et al.   CIRCULATION

Neuroprotective effect of volatile anesthetic agents: molecular mechanisms

(2009) Gerald A. Matchett et al.   NEUROLOGICAL RESEARCH

Re-canalization in acute ischemic stroke: The strategies

(2009) JeyarajDurai Pandian   NEUROLOGY INDIA

Curcumin produces neuroprotective effects via activating brain-derived neurotrophic factor/TrkB-dependent MAPK and PI-3K cascades in rodent cortical neurons

(2009) Rui Wang et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Severe Blood–Brain Barrier Disruption and Surrounding Tissue Injury

(2009) Bo Chen et al.   STROKE

Recombinant Human Erythropoietin in the Treatment of Acute Ischemic Stroke

(2009) Hannelore Ehrenreich et al.   STROKE

Efficacy and Safety of Tissue Plasminogen Activator 3 to 4.5 Hours After Acute Ischemic Stroke

(2009) Maarten G. Lansberg et al.   STROKE

Routine Use of Intravenous Low-Dose Recombinant Tissue Plasminogen Activator in Japanese Patients

(2009) Kazunori Toyoda et al.   STROKE

Mismatch-Based Delayed Thrombolysis

(2009) Nishant K. Mishra et al.   STROKE

Curcumin protects against glutamate excitotoxicity in rat cerebral cortical neurons by increasing brain-derived neurotrophic factor level and activating TrkB

(2008) Rui Wang et al.   BRAIN RESEARCH

The Novel Antioxidant Edaravone: From Bench to Bedside

(2008) Toshiaki Watanabe et al.   Cardiovascular Therapeutics

The lipophilic multifunctional antioxidant edaravone (radicut) improves behavior following embolic strokes in rabbits: A combination therapy study with tissue plasminogen activator

(2008) Paul A. Lapchak et al.   EXPERIMENTAL NEUROLOGY

A broadly neuroprotective derivative of curcumin

(2008) Yuanbin Liu et al.   JOURNAL OF NEUROCHEMISTRY

Thrombolysis with Alteplase 3 to 4.5 Hours after Acute Ischemic Stroke

(2008) Werner Hacke et al.   NEW ENGLAND JOURNAL OF MEDICINE

The Neurovascular Unit in Health and Disease: Introduction

(2008) E. H. Lo et al.   STROKE