Journal
TRANSLATIONAL STROKE RESEARCH
Volume 3, Issue 1, Pages 22-35Publisher
SPRINGER
DOI: 10.1007/s12975-011-0111-3
Keywords
Cell-labeling strategies; Stem cell engraftment; Monitoring of stem cell dynamics; Neurogenesis; Functional improvement; Functional MRI
Categories
Funding
- EU [HEALTH-F5-2008-201842]
- German Federal Ministry of Education and Research [BMBF-0314104]
- Instituto Carlos III of the Spanish Ministry of Health
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Magnetic resonance has an established role in investigations on the evolution of stroke and the assessment of therapeutic strategies in experimental animals. Here we show that the technique has also an important place for the study of stem cell-mediated regenerative therapies after stroke. We review the literature by bridging from the methodological aspects of stem cell labeling via grafting and monitoring of cell dynamics after implantation into the brain all the way to MRI's role in analyzing the stem cell-mediated functional improvement. Thus, we have aimed at a view combining the focus on the monitoring of the cell activities with the aspect of lesion evolution while including also the essence of a potential functional improvement by the implantation of stem cells following stroke.
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