The Development of Toad Toxins as Potential Therapeutic Agents

Cinobufagin induces apoptosis of osteosarcoma cells through inactivation of Notch signaling

(2017) Yongfei Cao et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Cane Toad Skin Extract-Induced Upregulation and Increased Interaction of Serotonin 2A and D2Receptors via Gq/11Signaling Pathway in CLU213 Cells

(2017) Abu Hasanat Md. Zulfiker et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Arenobufagin inhibits prostate cancer epithelial-mesenchymal transition and metastasis by down-regulating β-catenin

(2017) Liping Chen et al.   PHARMACOLOGICAL RESEARCH

Bufalin Inhibits the Inflammatory Effects in Asthmatic Mice through the Suppression of Nuclear Factor-Kappa B Activity

(2017) Zibierguli Zhakeer et al.   PHARMACOLOGY

Arenobufagin activates p53 to trigger esophageal squamous cell carcinoma cell apoptosis in vitro and in vivo

(2017) Junhong Lv et al.   OncoTargets and Therapy

Bufalin induces apoptosis in vitro and has Antitumor activity against human lung cancer xenografts in vivo

(2016) Shin-Hwar Wu et al.   ENVIRONMENTAL TOXICOLOGY

Aqueous and Ethanol Extracts of Australian Cane Toad Skins Suppress Pro-Inflammatory Cytokine Secretion in U937 Cells via NF-κB Signaling Pathway

(2016) Abu Hasanat Md. Zulfiker et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Chemical profiling and cytotoxicity assay of bufadienolides in toad venom and toad skin

(2016) Qiong Meng et al.   JOURNAL OF ETHNOPHARMACOLOGY

Multi-constituent identification in Australian cane toad skin extracts using high-performance liquid chromatography high-resolution tandem mass spectrometry

(2016) Abu Hasanat Md. Zulfiker et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

A New Indole Alkaloid from the Toad Venom of Bufo bufo gargarizans

(2016) Ying-Hui Dai et al.   MOLECULES

Effects of active bufadienolide compounds on human cancer cells and CD4+CD25+Foxp3+ regulatory T cells in mitogen-activated human peripheral blood mononuclear cells

(2016) Bo Yuan et al.   ONCOLOGY REPORTS

Gamabufotalin triggers c-Myc degradation via induction of WWP2 in multiple myeloma cells

(2016) Zhenlong Yu et al.   Oncotarget

Bufalin Inhibits NCI-H460 Human Lung Cancer Cell Metastasis In Vitro by Inhibiting MAPKs, MMPs, and NF-κB Pathways

(2015) Shin-Hwar Wu et al.   AMERICAN JOURNAL OF CHINESE MEDICINE

Chansu inhibits the expression of cortactin in colon cancer cell lines in vitro and in vivo

(2015) Chun Li et al.   BMC Complementary and Alternative Medicine

Huachansu mediates cell death in non-Hodgkin’s lymphoma by induction of caspase-3 and inhibition of MAP kinase

(2015) EKEM T. EFUET et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Structures and characterization of digoxin- and bufalin-bound Na+,K+-ATPase compared with the ouabain-bound complex

(2015) Mette Laursen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bufalin Inhibits HCT116 Colon Cancer Cells and Its Orthotopic Xenograft Tumor in Mice Model through Genes Related to Apoptotic and PTEN/AKT Pathways

(2015) Jie Wang et al.   Gastroenterology Research and Practice

Gamabufotalin, a major derivative of bufadienolide, inhibits VEGF-induced angiogenesis by suppressing VEGFR-2 signaling pathway

(2015) Ning Tang et al.   Oncotarget

Toad Glandular Secretions and Skin Extractions as Anti-Inflammatory and Anticancer Agents

(2014) Ji Qi et al.   Evidence-based Complementary and Alternative Medicine

Bufalin attenuates the stage and metastatic potential of hepatocellular carcinoma in nude mice

(2014) Zhou-Ji Zhang et al.   Journal of Translational Medicine

Anti-Inflammatory and Antinociceptive Activities of Bufalin in Rodents

(2014) Lili Wen et al.   MEDIATORS OF INFLAMMATION

Gamabufotalin, a bufadienolide compound from toad venom, suppresses COX-2 expression through targeting IKKβ/NF-κB signaling pathway in lung cancer cells

(2014) Zhenlong Yu et al.   Molecular Cancer

Comparison of toad skins Bufo bufo gargarizans Cantor from different regions for their active constituents content and cytotoxic activity on lung carcinoma cell lines

(2014) Congyan Liu et al.   Pharmacognosy Magazine

Anti-tumor Activity and Apoptosis-regulation Mechanisms of Bufalin in Various Cancers: New Hope for Cancer Patients

(2013) Pei-Hao Yin et al.   Asian Pacific Journal of Cancer Prevention

Rapid identification of primary constituents in parotoid gland secretions of the Australian cane toad using HPLC/MS-Q-TOF

(2013) Jing Jing et al.   BIOMEDICAL CHROMATOGRAPHY

Arenobufagin, a natural bufadienolide from toad venom, induces apoptosis and autophagy in human hepatocellular carcinoma cells through inhibition of PI3K/Akt/mTOR pathway

(2013) Dong-Mei Zhang et al.   CARCINOGENESIS

Bufalin inhibits migration and invasion in human hepatocellular carcinoma SK-Hep1 cells through the inhibitions of NF-kB and matrix metalloproteinase-2/-9-signaling pathways

(2013) Ya-Yin Chen et al.   ENVIRONMENTAL TOXICOLOGY

The Mechanisms of Chansu in Inducing Efficient Apoptosis in Colon Cancer Cells

(2013) Chun Li et al.   Evidence-based Complementary and Alternative Medicine

Structure–Activity Relationship Analysis of Bufadienolide-Induced in Vitro Growth Inhibitory Effects on Mouse and Human Cancer Cells

(2013) Laetitia Moreno Y. Banuls et al.   JOURNAL OF NATURAL PRODUCTS

Preparative separation and purification of bufadienolides from ChanSu by high-speed counter-current chromatography combined with preparative HPLC

(2013) Jialian Li et al.   QUIMICA NOVA

Bufalin, a Traditional Oriental Medicine, Induces Apoptosis in Human Cancer Cells

(2012) Noriyuki Takai et al.   Asian Pacific Journal of Cancer Prevention

Arenobufagin, a bufadienolide compound from toad venom, inhibits VEGF-mediated angiogenesis through suppression of VEGFR-2 signaling pathway

(2012) Manmei Li et al.   BIOCHEMICAL PHARMACOLOGY

Prospective randomised evaluation of traditional Chinese medicine combined with chemotherapy: a randomised phase II study of wild toad extract plus gemcitabine in patients with advanced pancreatic adenocarcinomas

(2012) Z Meng et al.   BRITISH JOURNAL OF CANCER

Simultaneous determination of eight bufadienolides in cinobufacini injection by HPLC coupled with triple quadrupole mass spectrometry

(2012) Xu Wu et al.   JOURNAL OF SEPARATION SCIENCE

Bufadienolide compounds sensitize human breast cancer cells to TRAIL-induced apoptosis via inhibition of STAT3/Mcl-1 pathway

(2011) Yinhui Dong et al.   APOPTOSIS

Improved antitumor efficacy and reduced toxicity of liposomes containing bufadienolides

(2011) Kaili Hu et al.   ARCHIVES OF PHARMACAL RESEARCH

Chemical Constituents and Bioactivities of the Skin of Bufo bufo gargarizansCantor

(2011) Dong-Liang Wang et al.   CHEMISTRY & BIODIVERSITY

Psychedelic 5-Methoxy-N,N-Dimethyltryptamine: Metabolism, Pharmacokinetics, Drug Interactions, and Pharmacological Actions

(2011) Hong-Wu Shen et al.   CURRENT DRUG METABOLISM

Bufothionine, a possible effective component in cinobufocini injection for hepatocellular carcinoma

(2011) Rui-Fang Xie et al.   JOURNAL OF ETHNOPHARMACOLOGY

Bufadienolides and their antitumor activity

(2011) Huimin Gao et al.   NATURAL PRODUCT REPORTS

Comparison of toad venoms from different Bufo species by HPLC and LC-DAD-MS/MS

(2010) Huimin Gao et al.   JOURNAL OF ETHNOPHARMACOLOGY

The Ecological Impact of Invasive Cane Toads (Bufo Marinus) in Australia

(2010) Richard Shine   QUARTERLY REVIEW OF BIOLOGY

Cytotoxic profile of natural and some modified bufadienolides from toad Rhinella schneideri parotoid gland secretion

(2010) Geraldino A. Cunha-Filho et al.   TOXICON

Pilot study of huachansu in patients with hepatocellular carcinoma, nonsmall-cell lung cancer, or pancreatic cancer

(2009) Zhiqiang Meng et al.   CANCER

The effects of telocinobufagin isolated from Chan Su on the activation and cytokine secretion of immunocytes in vitro

(2009) Yongguo Cao et al.   FUNDAMENTAL & CLINICAL PHARMACOLOGY

NF- B as a Critical Link Between Inflammation and Cancer

(2009) M. Karin   Cold Spring Harbor Perspectives in Biology

Apoptotic signaling in bufalin- and cinobufagin-treated androgen-dependent and -independent human prostate cancer cells

(2008) Ching-Han Yu et al.   CANCER SCIENCE

Novel therapeutic applications of cardiac glycosides

(2008) Ioannis Prassas et al.   NATURE REVIEWS DRUG DISCOVERY

Actinomycetes isolated from medicinal plant rhizosphere soils: diversity and screening of antifungal compounds, indole-3-acetic acid and siderophore production

(2008) Sutthinan Khamna et al.   WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY