Journal
TOXINS
Volume 5, Issue 5, Pages 1043-1050Publisher
MDPI AG
DOI: 10.3390/toxins5051043
Keywords
Terebridae venom; gland extracts; acetylcholine receptors; potassium channels; sodium channels
Categories
Funding
- CONCO
- European Commission [Ndegrees 037592, FP6-2005-LIFESCIHEALTH-6]
- research funding programme LOEWE-Landes-Offensive zur Entwicklung Wissenschaftlich-okonomischer Exzellenz
- Hesse's Ministry of Higher Education, Research, and the Arts
- DFG [NI 592/5-2]
- EU-FP7-MAREX
- Inter-University Attraction Poles Program, Belgian State, Belgian Science Policy [OT/12/081]
- [G.0433.12]
- [G.A071.10N]
- [G.0257.08]
- [IUAP 7/10]
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Venoms from cone snails (Conidae) have been extensively studied during the last decades, but those from other members of the suborder Toxoglossa, such as of Terebridae and Turridae superfamilies attracted less interest so far. Here, we report the effects of venom and gland extracts from three species of the superfamily Terebridae. By 2-electrode voltage-clamp technique the gland extracts were tested on Xenopus oocytes expressing nicotinic acetylcholine receptors (nAChRs) of rat neuronal (alpha(3)beta(2), alpha(3)beta(4), alpha(4)beta(2), alpha(4)beta(4), alpha 7) and muscle subtypes (alpha(1)beta(1)gamma delta), and expressing potassium (Kv1.2 and Kv1.3) and sodium channels (Nav1.2, 1.3, 1.4, 1.6). The extracts were shown to exhibit remarkably high inhibitory activities on almost all nAChRs tested, in particular on the a7 subtype suggesting the presence of peptides of the A-superfamily from the venom of Conus species. In contrast, no effects on the potassium and sodium channels tested were observed. The venoms of terebrid snails may offer an additional source of novel biologically active peptides.
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