Towards Clinical Applications of Anti-endotoxin Antibodies; A Re-appraisal of the Disconnect

Effect of Eritoran, an Antagonist of MD2-TLR4, on Mortality in Patients With Severe Sepsis

(2013) Steven M. Opal et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Prognostic Value of Endotoxemia in Patients with Gram-Negative Bacteremia Is Bacterial Species Dependent

(2013) James C. Hurley et al.   Journal of Innate Immunity

Genomic responses in mouse models poorly mimic human inflammatory diseases

(2013) Junhee Seok et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Animal models of sepsis

(2013) Mitchell P Fink   Virulence

L-form bacteria, cell walls and the origins of life

(2013) J. Errington   Open Biology

Recognition of lipid A variants by the TLR4-MD-2 receptor complex

(2013) Nina Maeshima et al.   Frontiers in Cellular and Infection Microbiology

Intracellular Vesicles as Reproduction Elements in Cell Wall-Deficient L-Form Bacteria

(2012) Yves Briers et al.   PLoS One

Peptide-based treatment of sepsis

(2011) Klaus Brandenburg et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Novel Therapies for Septic Shock Over the Past 4 Decades

(2011) Anthony F. Suffredini et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Polymyxin B for endotoxin removal in sepsis

(2011) Jean-Marc Cavaillon   LANCET INFECTIOUS DISEASES

New Antiseptic Peptides To Protect against Endotoxin-Mediated Shock

(2010) T. Gutsmann et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Systematic review of reviews including animal studies addressing therapeutic interventions for sepsis*

(2010) François Lamontagne et al.   CRITICAL CARE MEDICINE

Early combination antibiotic therapy yields improved survival compared with monotherapy in septic shock: A propensity-matched analysis*

(2010) Anand Kumar et al.   CRITICAL CARE MEDICINE

Endotoxin removal devices for the treatment of sepsis and septic shock

(2010) B Davies et al.   LANCET INFECTIOUS DISEASES

Endotoxin elimination in sepsis: physiology and therapeutic application

(2010) Klaus Buttenschoen et al.   LANGENBECKS ARCHIVES OF SURGERY

Clinical Results of Treatment of Postsurgical Endotoxin-Mediated Sepsis With Polymyxin-B Direct Hemoperfusion

(2010) G. Novelli et al.   TRANSPLANTATION PROCEEDINGS

Evolving Concepts in Sepsis Definitions

(2009) Jean-Louis Vincent et al.   CRITICAL CARE CLINICS

Sepsis: Time to reconsider the concept

(2009) Jean Carlet et al.   CRITICAL CARE MEDICINE

Alkaline phosphatase treatment improves renal function in severe sepsis or septic shock patients*

(2009) Suzanne Heemskerk et al.   CRITICAL CARE MEDICINE

Efficacy and safety of a phospholipid emulsion (GR270773) in Gram-negative severe sepsis: Results of a phase II multicenter, randomized, placebo-controlled, dose-finding clinical trial

(2009) R Phillip Dellinger et al.   CRITICAL CARE MEDICINE

Phase 2 trial of eritoran tetrasodium (E5564), a Toll-like receptor 4 antagonist, in patients with severe sepsis*

(2009) Mark Tidswell et al.   CRITICAL CARE MEDICINE

Does gram-negative bacteraemia occur without endotoxaemia? A meta-analysis using hierarchical summary ROC curves

(2009) J. C. Hurley   EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES

Polymyxin B Hemoperfusion and Mortality in Abdominal Septic Shock

(2009) Andre C. K. B. Amaral   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Polymyxin B Hemoperfusion and Mortality in Abdominal Septic Shock

(2009) Jean-Louis Vincent   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Early Use of Polymyxin B Hemoperfusion in Abdominal Septic Shock

(2009) Dinna N. Cruz et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Diagnosis of Endotoxemia with Gram-Negative Bacteremia Is Bacterial Species Dependent: a Meta-Analysis of Clinical Studies

(2009) J. C. Hurley   JOURNAL OF CLINICAL MICROBIOLOGY

Working toward the Future: Insights into Francisella tularensis Pathogenesis and Vaccine Development

(2009) R. D. Pechous et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

The structural basis of lipopolysaccharide recognition by the TLR4–MD-2 complex

(2009) Beom Seok Park et al.   NATURE

Endotoxin tolerance: new mechanisms, molecules and clinical significance

(2009) Subhra K. Biswas et al.   TRENDS IN IMMUNOLOGY

Translational research in the development of novel sepsis therapeutics: Logical deductive reasoning or mission impossible?

(2008) Steven M. Opal et al.   CRITICAL CARE MEDICINE

Animal models of sepsis: Why does preclinical efficacy fail to translate to the clinical setting?

(2008) Alex Dyson et al.   CRITICAL CARE MEDICINE

Sepsis: rethinking the approach to clinical research

(2008) John C. Marshall   JOURNAL OF LEUKOCYTE BIOLOGY