Scorpion Toxins Specific for Potassium (K+) Channels: A Historical Overview of Peptide Bioengineering

Looking over Toxin–K+ Channel Interactions. Clues from the Structural and Functional Characterization of α-KTx Toxin Tc32, a Kv1.3 Channel Blocker

(2012) Eliana G. Stehling et al.   BIOCHEMISTRY

Solution Structure of Kurtoxin: A Gating Modifier Selective for Cav3 Voltage-Gated Ca2+ Channels

(2012) Chul Won Lee et al.   BIOCHEMISTRY

Drugs from Slugs. Part II – Conopeptide bioengineering

(2012) Jon-Paul Bingham et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Engineering of Conotoxins for the Treatment of Pain

(2012) Bodil B. Carstens et al.   CURRENT PHARMACEUTICAL DESIGN

Discovery and Applications of Disulfide-Rich Cyclic Peptides

(2012) Masa Cemazar et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Cyclotides as a basis for drug design

(2012) David J Craik et al.   Expert Opinion on Drug Discovery

Methylation of γ-Carboxylated Glu (Gla) Allows Detection by Liquid Chromatography–Mass Spectrometry and the Identification of Gla Residues in the γ-Glutamyl Carboxylase

(2012) K. W. Hallgren et al.   JOURNAL OF PROTEOME RESEARCH

Photocontrol of Tyrosine Phosphorylation in Mammalian Cells via Genetic Encoding of Photocaged Tyrosine

(2012) Eyal Arbely et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Cone snail milked venom dynamics – A quantitative study of Conus purpurascens

(2012) Joycelyn B.S. Chun et al.   TOXICON

Wernerius inyoensis, an elusive new scorpion from the Inyo Mountains of California (Scorpiones, Vaejovidae)

(2012) Michael Webber et al.   ZooKeys

Solution structure of BTK-2, a novel hKv1.1 inhibiting scorpion toxin, from the eastern Indian scorpion Mesobuthus tamulus

(2011) G. Senthil Kumar et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Subcellular Protein Localization by Using a Genetically Encoded Fluorescent Amino Acid

(2011) Godefroid Charbon et al.   CHEMBIOCHEM

Characterization of γ-Carboxylated Tryptic Peptides by Collision-Induced Dissociation and Electron Transfer Dissociation Mass Spectrometry

(2011) Margareta Ramström et al.   EUROPEAN JOURNAL OF MASS SPECTROMETRY

Chemical Re-engineering of Chlorotoxin Improves Bioconjugation Properties for Tumor Imaging and Targeted Therapy

(2011) Muharrem Akcan et al.   JOURNAL OF MEDICINAL CHEMISTRY

Open structure of the Ca2+ gating ring in the high-conductance Ca2+-activated K+ channel

(2011) Peng Yuan et al.   NATURE

ConoServer: updated content, knowledge, and discovery tools in the conopeptide database

(2011) Q. Kaas et al.   NUCLEIC ACIDS RESEARCH

Click-enabled heterotrifunctional template for sequential bioconjugations

(2011) David M. Beal et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Unique scorpion toxin with a putative ancestral fold provides insight into evolution of the inhibitor cystine knot motif

(2011) J. J. Smith et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Expressed protein ligation for the preparation of fusion proteins with cell penetrating peptides for endotoxin removal and intracellular delivery

(2010) Hao-Hsin Yu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

MeuTXKβ1, a scorpion venom-derived two-domain potassium channel toxin-like peptide with cytolytic activity

(2010) Shunyi Zhu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Characterization of two linear cationic antimalarial peptides in the scorpion Mesobuthus eupeus

(2010) Bin Gao et al.   BIOCHIMIE

A potent potassium channel blocker from Mesobuthus eupeus scorpion venom

(2010) Bin Gao et al.   BIOCHIMIE

A facile, click chemistry-based approach to assembling fluorescent chemosensors for protein tyrosine kinases

(2010) Mohd Aizuddin Kamaruddin et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Ralph F. Hirschmann award address 2009: Merger of organic chemistry with peptide diversity

(2010) Morten Meldal et al.   BIOPOLYMERS

Invited reviewnative chemical ligation applied to the synthesis and bioengineering of circular peptides and proteins

(2010) Richard J. Clark et al.   BIOPOLYMERS

Total chemical synthesis and X-ray structure of kaliotoxin by racemic protein crystallography

(2010) Brad L. Pentelute et al.   CHEMICAL COMMUNICATIONS

Immunomodulation of voltage-dependent K+channels in macrophages: molecular and biophysical consequences

(2010) Núria Villalonga et al.   JOURNAL OF GENERAL PHYSIOLOGY

Proteomic Analysis Provides Insights on Venom Processing inConus textile

(2010) Lemmuel L. Tayo et al.   JOURNAL OF PROTEOME RESEARCH

ArachnoServer 2.0, an updated online resource for spider toxin sequences and structures

(2010) V. Herzig et al.   NUCLEIC ACIDS RESEARCH

Conopeptide characterization and classifications: An analysis using ConoServer

(2010) Quentin Kaas et al.   TOXICON

Cyclization of conotoxins to improve their biopharmaceutical properties

(2010) Richard J. Clark et al.   TOXICON

Modular Strategy for the Semisynthesis of a K+Channel: Investigating Interactions of the Pore Helix

(2009) Alexander G. Komarov et al.   ACS Chemical Biology

ArachnoServer: a database of protein toxins from spiders

(2009) David LA Wood et al.   BMC GENOMICS

The K+channels KCa3.1 and Kv1.3 as novel targets for asthma therapy

(2009) Peter Bradding et al.   BRITISH JOURNAL OF PHARMACOLOGY

Kv7 Channels as Targets for the Treatment of Pain

(2009) A. Wickenden et al.   CURRENT PHARMACEUTICAL DESIGN

Senicapoc (ICA-17043): a potential therapy for the prevention and treatment of hemolysis-associated complications in sickle cell anemia

(2009) Kenneth I Ataga et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Voltage-gated potassium channels as therapeutic targets

(2009) Heike Wulff et al.   NATURE REVIEWS DRUG DISCOVERY

T3DB: a comprehensively annotated database of common toxins and their targets

(2009) Emilia Lim et al.   NUCLEIC ACIDS RESEARCH

Synthesis of an iberiotoxin derivative by chemical ligation: A method for improved yields of cysteine-rich scorpion toxin peptides

(2009) Jon-Paul Bingham et al.   PEPTIDES

A designer ligand specific for Kv1.3 channels from a scorpion neurotoxin-based library

(2009) Zoltan Takacs et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Animal Toxins Acting on Voltage-Gated Potassium Channels

(2008) Stephanie Mouhat et al.   CURRENT PHARMACEUTICAL DESIGN

Structural Basis of a Potent Peptide Inhibitor Designed for Kv1.3 Channel, a Therapeutic Target of Autoimmune Disease

(2008) Song Han et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Kv7.1 (KCNQ1) properties and channelopathies

(2008) David Peroz et al.   JOURNAL OF PHYSIOLOGY-LONDON

Direct solid-phase synthesis and fluorescence labeling of large, monodisperse mannosylated dendrons in a peptide synthesizer

(2008) Eric Assen B. Kantchev et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Potassium channels - multiplicity and challenges

(2006) Donald H Jenkinson   BRITISH JOURNAL OF PHARMACOLOGY