Emerging Opportunities for Serotypes of Botulinum Neurotoxins

Insights into the Different Catalytic Activities of Clostridium Neurotoxins

(2012) Sheng Chen et al.   BIOCHEMISTRY

Purification, Modeling, and Analysis of Botulinum Neurotoxin Subtype A5 (BoNT/A5) from Clostridium botulinum Strain A661222

(2011) Mark J. Jacobson et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Botulinum toxin type-A effect as a preemptive treatment in a model of acute trigeminal pain: a pre-clinical double-blind and placebo-controlled study

(2011) Elcio Juliato Piovesan et al.   ARQUIVOS DE NEURO-PSIQUIATRIA

Structural and mutational analyses of the receptor binding domain of botulinum D/C mosaic neurotoxin: Insight into the ganglioside binding mechanism

(2011) Nipawan Nuemket et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Syntaxin Requirement for Ca2+-Triggered Exocytosis in Neurons and Endocrine Cells Demonstrated with an Engineered Neurotoxin

(2011) Dongsheng Wang et al.   BIOCHEMISTRY

Clostridium botulinum group III: a group with dual identity shaped by plasmids, phages and mobile elements

(2011) Hanna Skarin et al.   BMC GENOMICS

Receptor Binding Enables Botulinum Neurotoxin B to Sense Low pH for Translocation Channel Assembly

(2011) Shihu Sun et al.   Cell Host & Microbe

Muscarinic Receptors: Their Roles in Disorders of the Central Nervous System and Potential as Therapeutic Targets

(2011) Elizabeth Scarr   CNS Neuroscience & Therapeutics

Molecular immune recognition of botulinum neurotoxin B. The light chain regions that bind human blocking antibodies from toxin-treated cervical dystonia patients. Antigenic structure of the entire BoNT/B molecule

(2011) M. Zouhair Atassi et al.   IMMUNOBIOLOGY

Studies of the Mechanistic Details of the pH-dependent Association of Botulinum Neurotoxin with Membranes

(2011) Darren J. Mushrush et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Unique Ganglioside Recognition Strategies for Clostridial Neurotoxins

(2011) Marc A. Benson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Botulinum Neurotoxin D Uses Synaptic Vesicle Protein SV2 and Gangliosides as Receptors

(2011) Lisheng Peng et al.   PLoS Pathogens

Botulinum Neurotoxin: A Marvel of Protein Design

(2010) Mauricio Montal   Annual Review of Biochemistry

Structural Analysis of Botulinum Neurotoxin Type G Receptor Binding,

(2010) John Schmitt et al.   BIOCHEMISTRY

Type E botulism

(2010) B Zane Horowitz   CLINICAL TOXICOLOGY

Botulinum neurotoxin subtype A2 enters neuronal cells faster than subtype A1

(2010) Christina L. Pier et al.   FEBS LETTERS

Licence for Botox in so-called chronic migraine

(2010) Jes Olesen et al.   LANCET

Neutralizing human monoclonal antibodies binding multiple serotypes of botulinum neurotoxin

(2010) C. Garcia-Rodriguez et al.   PROTEIN ENGINEERING DESIGN & SELECTION

Catalytic Properties of Botulinum Neurotoxin Subtypes A3 and A4†

(2009) James S. Henkel et al.   BIOCHEMISTRY

Glycosylated SV2 and Gangliosides as Dual Receptors for Botulinum Neurotoxin Serotype F

(2009) Zhuji Fu et al.   BIOCHEMISTRY

Neuro-exocytosis: botulinum toxins as inhibitory probes and versatile therapeutics☆

(2009) J Oliver Dolly et al.   CURRENT OPINION IN PHARMACOLOGY

Long-term efficacy and tolerability of 4-monthly versus yearly botulinum toxin type A treatment for lower-limb spasticity in children with cerebral palsy

(2009) PETR KAŇOVSKÝ et al.   DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY

Intrahippocampal infusion of botulinum neurotoxin E (BoNT/E) reduces spontaneous recurrent seizures in a mouse model of mesial temporal lobe epilepsy

(2009) Flavia Antonucci et al.   EPILEPSIA

FDA Requires Black Box Warnings on Labeling for Botulinum Toxin Products

(2009) Bridget M. Kuehn   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Genetic Characterization of Clostridium botulinum Associated with Type B Infant Botulism in Japan

(2009) K. Umeda et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Botulinum neurotoxins C, E and F bind gangliosides via a conserved binding site prior to stimulation-dependent uptake with botulinum neurotoxin F utilising the three isoforms of SV2 as second receptor

(2009) Andreas Rummel et al.   JOURNAL OF NEUROCHEMISTRY

Characterization of the D/C mosaic neurotoxin produced by Clostridium botulinum associated with bovine botulism in Japan

(2009) Keiji Nakamura et al.   VETERINARY MICROBIOLOGY

Beneficial effects of botulinum toxin type A in trigeminal neuralgia

(2008) Carlos Zúñiga et al.   ARQUIVOS DE NEURO-PSIQUIATRIA

Glutamate Uptake and Release by Astrocytes Are Enhanced byClostridium botulinumC3 Protein

(2008) Markus Höltje et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Domain Organization in Clostridium botulinum Neurotoxin Type E Is Unique: Its Implication in Faster Translocation

(2008) Desigan Kumaran et al.   JOURNAL OF MOLECULAR BIOLOGY

Glycosylated SV2A and SV2B Mediate the Entry of Botulinum Neurotoxin E into Neurons

(2008) Min Dong et al.   MOLECULAR BIOLOGY OF THE CELL

Clinical Comparisons of Botulinum Neurotoxin Formulations

(2008) Allison Brashear   NEUROLOGIST

Subcutaneous Botulinum toxin type A reduces capsaicin-induced trigeminal pain and vasomotor reactions in human skin

(2008) Parisa Gazerani et al.   PAIN

Regulation of the V-ATPase along the Endocytic Pathway Occurs through Reversible Subunit Association and Membrane Localization

(2008) Céline Lafourcade et al.   PLoS One

Xeomin® is stable without refrigeration: Complexing proteins are not required for stability of botulinum neurotoxin type A preparations

(2008) Swen Grein et al.   TOXICON

Disease-oriented approach to botulinum toxin use

(2008) Joseph Jankovic   TOXICON

Botulinum neurotoxin E (BoNT/E) reduces CA1 neuron loss and granule cell dispersion, with no effects on chronic seizures, in a mouse model of temporal lobe epilepsy

(2007) Flavia Antonucci et al.   EXPERIMENTAL NEUROLOGY