Article
Multidisciplinary Sciences
Hong-Chieh Tsai, Han-Hsing Tsou, Chun-Chi Lin, Shao-Chen Chen, Hsiao-Wei Cheng, Tsung-Yun Liu, Wei-Shone Chen, Jeng-Kai Jiang, Shung-Haur Yang, Shih-Ching Chang, Hao-Wei Teng, Hsiang-Tsai Wang
Summary: Colorectal cancer is a well-known malignancy with high prevalence and poor 5-year survival, and a high-fat diet may increase the odds of developing this cancer. Acrolein plays a crucial role in oncogenic transformation through activation of the RAS/MAPK signaling pathway in colon tumorigenesis.
SCIENTIFIC REPORTS
(2021)
Article
Environmental Sciences
Carine Al-Ayoubi, Maria Alonso-Jauregui, Amaya Azqueta, Julien Vignard, Gladys Mirey, Ophelie Rocher, Olivier Puel, Isabelle P. Oswald, Ariane Vettorazzi, Laura Soler
Summary: Versicolorin A (VerA), a precursor of Aflatoxin B1 (AFB1), induces genotoxicity by causing DNA damage and activating DNA repair pathways. This study highlights the potential carcinogenicity of VerA exposure, even at low concentrations, and calls for further research on this emerging food contaminant.
ENVIRONMENTAL POLLUTION
(2023)
Article
Materials Science, Biomaterials
Anna Fakhardo, Elizaveta Anastasova, Victor Makarov, Evgeniia Ikonnikova, Ekaterina Kulko, Nikol Agadzhanian, Marina Yakunina, Liubov Shkodenko, Sofia Tsvetikova, Maria Toropko, Elena Koshel, Mikhail Zakharov, Georgii Alexandrov, Olga Khuttunen, Pavel Kulikov, Oleg Burmistrov, Vladimir Vinogradov, Artur Prilepskii
Summary: The study demonstrates that the prepared heparin-coated iron oxide nanoparticles can be used as a contrast agent for cholangioma tumors in the liver without notable toxic effects on experimental animals, while exhibiting mutagenicity. Pharmacokinetic studies show that these nanoparticles can circulate in the body for up to 14 days.
JOURNAL OF MATERIALS CHEMISTRY B
(2022)
Article
Chemistry, Multidisciplinary
Giorgia La Barbera, Katrine Dalmo Nommesen, Catalina Cuparencu, Jan Stanstrup, Lars Ove Dragsted
Summary: The field of DNA adductomics aims to screen known and unknown DNA adducts in biological samples. However, the lack of databases and bioinformatics tools in this field limits its applicability. This paper presents a four-step approach to compile and curate a database for the annotation of DNA adducts in biological samples, providing a powerful tool for (HR)MS-based DNA adduct annotation.
FRONTIERS IN CHEMISTRY
(2022)
Article
Pharmacology & Pharmacy
Melanie Hemgesberg, Simone Stegmuller, Alexander Cartus, Dieter Schrenk
Summary: The study found that a background level of N7-GA-Gua adducts exists in untreated hepatocytes, and incubation with AA at concentrations below 500μM did not result in a significant increase in adduct levels. However, significant increases in N7-GA-Gua levels were found at concentrations above 500μM, and BMC modeling of the data showed non-linear concentration-response curves, indicating that AA only started to cause measurable increases in N7-GA-Gua levels above certain concentrations.
Article
Food Science & Technology
Cristina Plata-Calzado, Leticia Diez-Quijada, Concepcion Medrano-Padial, Ana I. I. Prieto, Ana M. M. Camean, Angeles Jos
Summary: The aim of this study was to explore the potential mutagenicity and genotoxicity of pure ATX-a and an ATX-a/CYN mixture. The results showed that ATX-a was not mutagenic but exhibited genotoxicity in the absence of S9 mix, while ATX-a/CYN mixture showed concentration-dependent genotoxicity only in the presence of S9. Therefore, further studies are necessary for more realistic risk assessments.
Article
Environmental Sciences
Douglas dos Santos Silva, Bruno Goncalves, Candido Carvalho Rodrigues, Felipe Cirqueira Dias, Nicholas Silvestre de Souza Trigueiro, Izabella Soares Moreira, Daniela de Melo e Silva, Simone Maria Teixeira Saboia-Morais, Tania Gomes, Thiago Lopes Rocha
Summary: Water safety is a global concern, with efforts being made to protect aquatic ecosystems. In this study, biomarker responses in caged Astyanax lacustris were evaluated in the Joao Leite river, central Brazilian Cerrado, along with land use classification and water parameter analysis. Results revealed high metal concentrations in the water, particularly near pasture areas, leading to genotoxic effects in caged fish. This study highlights the importance of using a multi-biomarker approach for environmental risk assessment in areas at higher risk of anthropogenic pollution.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Chemistry, Multidisciplinary
Ana Laura Gadelha Castro, Jorddy Neves Cruz, Daniele Ferreira Sodre, Juliana Correa-Barbosa, Rufine Azonsivo, Mozaniel Santana de Oliveira, Jose Edson de Sousa Siqueira, Natasha Costa da Rocha Galucio, Marcelo de Oliveira Bahia, Rommel Mario Rodriguez Burbano, Andrey Moacir do Rosario Marinho, Sandro Percario, Maria Fani Dolabela, Valdicley Vieira Vale
Summary: This study evaluated the genotoxicity and mutagenicity of isoeleutherin and eleutherin in Eleutherine plicata Herb., showing that eleutherin is more genotoxic than isoeleutherin. The molecular docking and MD simulations demonstrated the compounds' ability to interact with TOPO II and form stable complexes, providing new insights into their genotoxic and mutagenic potential.
ARABIAN JOURNAL OF CHEMISTRY
(2021)
Review
Chemistry, Multidisciplinary
Josefa Domenech, Adriana Rodriguez-Garraus, Adela Lopez de Cerain, Amaya Azqueta, Julia Catalan
Summary: Graphene-based materials (GBMs) are a broad family of carbon-based nanomaterials widely used in nanotechnology. The potential genotoxicity of GBMs has raised concerns in terms of human health. Existing literature suggests that certain GBMs have the potential to induce genetic damage, although the specific damage type depends on the material. However, the variability in GBMs, cellular systems, and research methods used in studies makes it difficult to identify the physico-chemical properties that drive the genotoxicity response to GBMs.
Article
Environmental Sciences
Abraao Tiago Batista Guimaraes, Fernanda Neves Estrela, Paulo Sergio Pereira, Julya Emmanuela de Andrade Vieira, Aline Sueli de Lima Rodrigues, Fabiano Guimaraes Silva, Guilherme Malafaia
Summary: The study found that polystyrene nanoplastics can cause DNA damage, mutagenic and cytotoxic effects in juvenile grass carp. Animals exposed to higher concentrations of the pollutant showed significant biochemical changes and substantial accumulation of these nanomaterials.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Food Science & Technology
Carina Quintanilha da Silva, Andreia da Silva Fernandes, Gabriela Felix Teixeira, Rodrigo Jose Franca, Monica Regina da Costa Marques, Israel Felzenszwalb, Deborah Quintanilha Falca, Elisa Raquel Anastacio Ferraz
Summary: This study evaluated the influence of coffee bean quality and roasting degree on mutagenicity, cytotoxicity and genotoxicity. The results showed that the formation of polycyclic aromatic hydrocarbons during the roasting process can have toxic effects on cells, and different qualities and roast degrees of coffee beans can lead to varying levels of toxicity on cells.
FOOD RESEARCH INTERNATIONAL
(2021)
Article
Food Science & Technology
Josefa Tolosa, Eva Serrano Candelas, Jose Luis Valles Pardo, Addel Goya, Salvador Moncho, Rafael Gozalbes, Martina Palomino Schaetzlein
Summary: Mycotoxins, which are produced by fungi, pose a threat to public health due to their potential carcinogenic, mutagenic, and teratogenic effects. This study developed a comprehensive database of 4360 mycotoxins classified into 170 categories. The use of QSAR models allowed for accurate and reliable prediction of mutagenicity, genotoxicity, and carcinogenicity, meeting regulatory criteria. The integrated web server provides a valuable tool for exploring the mycotoxin database and predicting toxicity.
Review
Environmental Sciences
Carlos Filipe Camilo-Cotrim, Elisa Flavia Luiz Cardoso Bailao, Luciana Souza Ondei, Fernanda Melo Carneiro, Luciane Madureira Almeida
Summary: This review summarizes the history of using the Allium cepa bioassay to investigate pesticide damages and discusses the data on experimental conditions. The reviewed studies demonstrate that the A. cepa bioassay is an effective model for evaluating pesticide toxicity and highlights the adverse effects of pesticides on humans and the environment.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Chemistry, Medicinal
Elena Lo Piparo, Nicolas Christinat, Flavia Badoud
Summary: This study aims to establish a correspondence between genotoxic structural alerts (SAs) and signature fragment alerts (SFAs), in order to analyze mixtures using computational toxicology. By screening signature fragment alerts, the presence of genotoxic substances in plant-based mixtures can be quickly identified. The SFA analysis can be used for risk prioritization of newly identified PAs and their identification in mixtures, reducing the unnecessary use of animal experimentation for genotoxicity testing.
CHEMICAL RESEARCH IN TOXICOLOGY
(2023)
Article
Environmental Sciences
Marina Marques Bonomo, Ivelise Teresa de Castro Sachi, Marcelo Gustavo Paulino, Joao Batista Fernandes, Rose Maria Carlos, Marisa Narciso Fernandes
Summary: This study evaluated the impact of a new metal insecticide, MgHP, on fish, showing genotoxicity, altered hematological variables, and liver histopathological changes, as well as potential recovery capability of organisms. Hematological and genotoxic effects were observed after 24 hours of exposure, with activation of the antioxidant defense system and DNA repair mechanisms.
ENVIRONMENTAL POLLUTION
(2021)