Brown Spider (Loxosceles genus) Venom Toxins: Tools for Biological Purposes

New Concepts in Phospholipase D Signaling in Inflammation and Cancer

(2011) Julian Gomez-Cambronero   TheScientificWorldJOURNAL

Phospholipase-D activity and inflammatory response induced by brown spider dermonecrotic toxin: Endothelial cell membrane phospholipids as targets for toxicity

(2010) Olga M. Chaim et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Ziconotide for treatment of severe chronic pain

(2010) Achim Schmidtko et al.   LANCET

A novel expression profile of the Loxosceles intermedia spider venomous gland revealed by transcriptome analysis

(2010) Luiza Helena Gremski et al.   Molecular BioSystems

The metzincins - Topological and sequential relations between the astacins, adamalysins, serralysins, and matrixins (collagenases) define a super family of zinc-peptidases

(2010) Walter Stöcker et al.   PROTEIN SCIENCE

Comparative analyses of venoms from American and African Sicarius spiders that differ in sphingomyelinase D activity

(2010) Pamela A. Zobel-Thropp et al.   TOXICON

Inflammatory mediators generated at the site of inoculation of Loxosceles gaucho spider venom

(2010) Katia C. Barbaro et al.   TOXICON

Loxoscelism: From basic research to the proposal of new therapies

(2010) Denise V. Tambourgi et al.   TOXICON

Hyaluronidase : plaidoyer pour un retour

(2009) B. Etesse et al.   ANNALES FRANCAISES D ANESTHESIE ET DE REANIMATION

Astacin-like metalloproteases are a gene family of toxins present in the venom of different species of the brown spider (genus Loxosceles)

(2009) Dilza Trevisan-Silva et al.   BIOCHIMIE

Inhibitive Effects of Alkyl Gallates on Hyaluronidase and Collagenase

(2009) Florin BARLA et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

ArachnoServer: a database of protein toxins from spiders

(2009) David LA Wood et al.   BMC GENOMICS

Textilinin-1, an alternative anti-bleeding agent to aprotinin: Importance of plasmin inhibition in controlling blood loss

(2009) Simone M. Flight et al.   BRITISH JOURNAL OF HAEMATOLOGY

Complex relationship between TCTP, microtubules and actin microfilaments regulates cell shape in normal and cancer cells

(2009) Franck Bazile et al.   CARCINOGENESIS

Subcutaneous immunoglobulin: opportunities and outlook

(2009) S. Misbah et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Structure and function of invertebrate Kazal-type serine proteinase inhibitors

(2009) Vichien Rimphanitchayakit et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

Identification of potential lung cancer biomarkers using an in vitro carcinogenesis model

(2009) Jung Eun Kim et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Hyaluronidase: a review of approved formulations, indications and off-label use in chronic pain management

(2009) Amber L Dunn et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Venomics as a drug discovery platform

(2009) Pierre Escoubas et al.   Expert Review of Proteomics

Crystal structure of textilinin-1, a Kunitz-type serine protease inhibitor from the venom of the Australian common brown snake (Pseudonaja textilis)

(2009) Emma-Karin I. Millers et al.   FEBS Journal

Targeting phospholipase D with small-molecule inhibitors as a potential therapeutic approach for cancer metastasis

(2009) Wenjuan Su et al.   Future Oncology

Identification of a direct hemolytic effect dependent on the catalytic activity induced by phospholipase-D (dermonecrotic toxin) from brown spider venom

(2009) Daniele Chaves-Moreira et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Whole-body synthesis secretion of docosahexaenoic acid from circulating eicosapentaenoic acid in unanesthetized rats

(2009) Fei Gao et al.   JOURNAL OF LIPID RESEARCH

The Role of Translationally Controlled Tumor Protein in Tumor Growth and Metastasis of Colon Adenocarcinoma Cells

(2009) Qiang Ma et al.   JOURNAL OF PROTEOME RESEARCH

Venomics: Digging into the evolution of venomous systems and learning to twist nature to fight pathology

(2009) Juan J. Calvete   Journal of Proteomics

Gramicidin Pores Report the Activity of Membrane-Active Enzymes

(2009) Sheereen Majd et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Significant overexpression of Hsp110 gene during colorectal cancer progression

(2009) Slaby   ONCOLOGY REPORTS

Brown Recluse Spider Venom: Proteomic Analysis and Proposal of a Putative Mechanism of Action

(2009) Lucilene dos Santos et al.   PROTEIN AND PEPTIDE LETTERS

Snake Venom Phospholipases A2: A New Class of Antitumor Agents

(2009) Renata Rodrigues et al.   PROTEIN AND PEPTIDE LETTERS

Erection induced by Tx2-6 toxin of Phoneutria nigriventer spider: Expression profile of genes in the nitric oxide pathway of penile tissue of mice

(2009) Fabiola E. Villanova et al.   TOXICON

Analysis of therapeutic benefits of antivenin at different time intervals after experimental envenomation in rabbits by venom of the brown spider (Loxosceles intermedia)

(2009) Isolete Pauli et al.   TOXICON

Arachnids misidentified as brown recluse spiders by medical personnel and other authorities in North America

(2009) Richard S. Vetter   TOXICON

A protective immune response against lethal, dermonecrotic and hemorrhagic effects of Loxosceles intermedia venom elicited by a 27-residue peptide

(2009) C. Dias-Lopes et al.   TOXICON

An in vivo protective response against toxic effects of the dermonecrotic protein from Loxoscelesintermedia spider venom elicited by synthetic epitopes

(2009) Liza Felicori et al.   VACCINE

Lysophosphatidic acid-induced transactivation of epidermal growth factor receptor regulates cyclo-oxygenase-2 expression and prostaglandin E2release via C/EBPβ in human bronchial epithelial cells

(2008) Donghong He et al.   BIOCHEMICAL JOURNAL

Nephrotoxicity caused by brown spider venom phospholipase-D (dermonecrotic toxin) depends on catalytic activity

(2008) J. Kusma et al.   BIOCHIMIE

Novel translationally controlled tumor protein homologue in the buccal gland secretion of Lampetra japonica

(2008) Jing Sun et al.   BIOCHIMIE

Penile erection inducedin vivoby a purified toxin from the Brazilian spiderPhoneutria nigriventer

(2008) Enrico Andrade et al.   BJU INTERNATIONAL

Transcriptome analysis of Loxosceles laeta (Araneae, Sicariidae) spider venomous gland using expressed sequence tags

(2008) Matheus de F Fernandes-Pedrosa et al.   BMC GENOMICS

TCTP protects from apoptotic cell death by antagonizing bax function

(2008) L Susini et al.   CELL DEATH AND DIFFERENTIATION

Inflammatory events induced by brown spider venom and its recombinant dermonecrotic toxin: A pharmacological investigation

(2008) Katia Sabrina Paludo et al.   COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY

News from an Ancient World: Two Novel Astacin Metalloproteases from the Horseshoe Crab

(2008) Christoph Becker-Pauly et al.   JOURNAL OF MOLECULAR BIOLOGY

Phylogenetic and Structural Analysis of Translationally Controlled Tumor Proteins

(2008) Jesús Hinojosa-Moya et al.   JOURNAL OF MOLECULAR EVOLUTION

Special issue: Metzincin metalloproteinases

(2008) E STERCHI   MOLECULAR ASPECTS OF MEDICINE

Molecular Evolution, Functional Variation, and Proposed Nomenclature of the Gene Family That Includes Sphingomyelinase D in Sicariid Spider Venoms

(2008) G. J. Binford et al.   MOLECULAR BIOLOGY AND EVOLUTION

Phylogenetic relationships of Loxosceles and Sicarius spiders are consistent with Western Gondwanan vicariance

(2008) Greta J. Binford et al.   MOLECULAR PHYLOGENETICS AND EVOLUTION

Chfr interacts and colocalizes with TCTP to the mitotic spindle

(2008) A Burgess et al.   ONCOGENE

Expression and characterization of LTx2, a neurotoxin from Lasiodora sp. effecting on calcium channels

(2008) A.A. Dutra et al.   PEPTIDES

Discovery of a Distinct Superfamily of Kunitz-Type Toxin (KTT) from Tarantulas

(2008) Chun-Hua Yuan et al.   PLoS One

Engineered specific and high-affinity inhibitor for a subtype of inward-rectifier K+ channels

(2008) Y. Ramu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NMR-spectroscopic screening of spider venom reveals sulfated nucleosides as major components for the brown recluse and related species

(2008) F. C. Schroeder et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hyalurondiase: Both a tumor promoter and suppressor

(2008) Vinata B. Lokeshwar et al.   SEMINARS IN CANCER BIOLOGY

A hyaluronidase from Potamotrygon motoro (freshwater stingrays) venom: Isolation and characterization

(2008) Marta R. Magalhães et al.   TOXICON

A rational nomenclature for naming peptide toxins from spiders and other venomous animals

(2008) Glenn F. King et al.   TOXICON

Milking and partial characterization of venom from the Brazilian spider Vitalius dubius (Theraphosidae)

(2008) Thomaz A.A. Rocha-e-Silva et al.   TOXICON

Molecular Mechanisms of PLD Function in Membrane Traffic

(2008) Michael G. Roth   TRAFFIC

Identification, cloning and functional characterization of a novel dermonecrotic toxin (phospholipase D) from brown spider (Loxosceles intermedia) venom

(2007) Marcia Helena Appel et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Biotechnological applications of brown spider (Loxosceles genus) venom toxins

(2007) Andrea Senff-Ribeiro et al.   BIOTECHNOLOGY ADVANCES

Nucleotidase and DNase activities in Brazilian snake venoms

(2007) Paulo Bruno Valadão Sales et al.   COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY

Primary culture of venom glands from the Brazilian armed spider, Phoneutria nigriventer (Araneae, Ctenidae)

(2007) Luciana Maria Silva et al.   TOXICON

Vascular permeability and vasodilation induced by the Loxosceles intermedia venom in rats: Involvement of mast cell degranulation, histamine and 5-HT receptors

(2007) Yanna D. Rattmann et al.   TOXICON