Cycle Inhibiting Factors (Cifs): Cyclomodulins That Usurp the Ubiquitin-Dependent Degradation Pathway of Host Cells

The bacterial effector Cif interferes with SCF ubiquitin ligase function by inhibiting deneddylation of Cullin1

(2010) Hanako Morikawa et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Evolutionary analysis and distribution of type III effector genes in pathogenic Escherichia coli from human, animal and food sources

(2010) Kristina Creuzburg et al.   ENVIRONMENTAL MICROBIOLOGY

The cyclomodulin Cif of Photorhabdus luminescens inhibits insect cell proliferation and triggers host cell death by apoptosis

(2010) Carolina Varela Chavez et al.   MICROBES AND INFECTION

Molecular analysis of the prokaryotic ubiquitin-like protein (Pup) conjugation pathway in Mycobacterium tuberculosis

(2010) Francisca A. Cerda-Maira et al.   MOLECULAR MICROBIOLOGY

Glutamine Deamidation and Dysfunction of Ubiquitin/NEDD8 Induced by a Bacterial Effector Family

(2010) J. Cui et al.   SCIENCE

Activation of  -Catenin in Dendritic Cells Regulates Immunity Versus Tolerance in the Intestine

(2010) S. Manicassamy et al.   SCIENCE

Pathogenic Bacteria Target NEDD8-Conjugated Cullins to Hijack Host-Cell Signaling Pathways

(2010) Grégory Jubelin et al.   PLoS Pathogens

Ubiquitin-mediated control of oncogene and tumor suppressor gene products

(2009) Kyoko Kitagawa et al.   CANCER SCIENCE

Regulation of cullin-RING E3 ubiquitin-ligases by neddylation and dimerization

(2009) J. Merlet et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Cif type III effector protein: a smart hijacker of the host cell cycle

(2009) Ascel Samba-Louaka et al.   Future Microbiology

The Enteropathogenic Escherichia coli Effector Cif Induces Delayed Apoptosis in Epithelial Cells

(2009) A. Samba-Louaka et al.   INFECTION AND IMMUNITY

E2-RING Expansion of the NEDD8 Cascade Confers Specificity to Cullin Modification

(2009) Danny T. Huang et al.   MOLECULAR CELL

Cullin Mediates Degradation of RhoA through Evolutionarily Conserved BTB Adaptors to Control Actin Cytoskeleton Structure and Cell Movement

(2009) Yuezhou Chen et al.   MOLECULAR CELL

An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer

(2009) Teresa A. Soucy et al.   NATURE

Bacterial ubiquitin-like modifier Pup is deamidated and conjugated to substrates by distinct but homologous enzymes

(2009) Frank Striebel et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Cycle Inhibiting Factors (CIFs) Are a Growing Family of Functional Cyclomodulins Present in Invertebrate and Mammal Bacterial Pathogens

(2009) Grégory Jubelin et al.   PLoS One

Crystal Structures of Cif from Bacterial Pathogens Photorhabdus luminescens and Burkholderia pseudomallei

(2009) Allister Crow et al.   PLoS One

A bacterial type III effector family uses the papain-like hydrolytic activity to arrest the host cell cycle

(2009) Q. Yao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular Analysis as an Aid To Assess the Public Health Risk of Non-O157 Shiga Toxin-Producing Escherichia coli Strains

(2008) B. K. Coombes et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Structural Insights into NEDD8 Activation of Cullin-RING Ligases: Conformational Control of Conjugation

(2008) David M. Duda et al.   CELL

Bacterial cyclomodulin Cif blocks the host cell cycle by stabilizing the cyclin-dependent kinase inhibitors p21waf1and p27kip1

(2008) Ascel Samba-Louaka et al.   CELLULAR MICROBIOLOGY

CDK Inhibitors: Cell Cycle Regulators and Beyond

(2008) Arnaud Besson et al.   DEVELOPMENTAL CELL

Genomic O Island 122, Locus for Enterocyte Effacement, and the Evolution of Virulent Verocytotoxin-Producing Escherichia coli

(2008) P. Konczy et al.   JOURNAL OF BACTERIOLOGY

Structure of the Cyclomodulin Cif from Pathogenic Escherichia coli

(2008) Yun Hsu et al.   JOURNAL OF MOLECULAR BIOLOGY

Multimodal Activation of the Ubiquitin Ligase SCF by Nedd8 Conjugation

(2008) Anjanabha Saha et al.   MOLECULAR CELL

Cullin-RING ubiquitin ligases: global regulation and activation cycles

(2008) Dimple R Bosu et al.   Cell Division