Clostridial Neurotoxins: Mechanism of SNARE Cleavage and Outlook on Potential Substrate Specificity Reengineering

The N-terminal half of the receptor domain of botulinum neurotoxin A binds to microdomains of the plasma membrane

(2009) Lucia Muraro et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Glycosylated SV2 and Gangliosides as Dual Receptors for Botulinum Neurotoxin Serotype F

(2009) Zhuji Fu et al.   BIOCHEMISTRY

Multiple roles of the vesicular-SNARE TI-VAMP in post-Golgi and endosomal trafficking

(2009) Mathilde Chaineau et al.   FEBS LETTERS

Botulinum neurotoxins C, E and F bind gangliosides via a conserved binding site prior to stimulation-dependent uptake with botulinum neurotoxin F utilising the three isoforms of SV2 as second receptor

(2009) Andreas Rummel et al.   JOURNAL OF NEUROCHEMISTRY

Mode of VAMP substrate recognition and inhibition of Clostridium botulinum neurotoxin F

(2009) Rakhi Agarwal et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Engineering botulinum neurotoxin to extend therapeutic intervention

(2009) S. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Engineering of protease variants exhibiting altered substrate specificity

(2008) Saravanan Sellamuthu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Catalytic Features of the Botulinum Neurotoxin A Light Chain Revealed by High Resolution Structure of an Inhibitory Peptide Complex†‡

(2008) Nicholas R. Silvaggi et al.   BIOCHEMISTRY

SNAP-25 Substrate Peptide (Residues 180–183) Binds to but Bypasses Cleavage by Catalytically ActiveClostridium botulinumNeurotoxin E

(2008) Rakhi Agarwal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure- and Substrate-based Inhibitor Design forClostridium botulinumNeurotoxin Serotype A

(2008) Desigan Kumaran et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Substrate Recognition Mechanism of VAMP/Synaptobrevin-cleaving Clostridial Neurotoxins

(2008) Stefan Sikorra et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Substrate Recognition of VAMP-2 by Botulinum Neurotoxin B and Tetanus Neurotoxin

(2008) Sheng Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Glycosylated SV2A and SV2B Mediate the Entry of Botulinum Neurotoxin E into Neurons

(2008) Min Dong et al.   MOLECULAR BIOLOGY OF THE CELL

Identification of Residues Surrounding the Active Site of Type A Botulinum Neurotoxin Important for Substrate Recognition and Catalytic Activity

(2008) S. Ashraf Ahmed et al.   PROTEIN JOURNAL

A Potent Peptidomimetic Inhibitor of Botulinum Neurotoxin Serotype A Has a Very Different Conformation than SNAP-25 Substrate

(2008) Jorge E. Zuniga et al.   STRUCTURE

Substrate Binding Mode and Its Implication on Drug Design for Botulinum Neurotoxin A

(2008) Desigan Kumaran et al.   PLoS Pathogens