Article
Polymer Science
Victor Delorme, Ghislain David, Stephane Dejean, Julia Mouton, Xavier Garric, Jean Coudane, Helene van den Berghe
Summary: Describes the synthesis of a fully biodegradable amphiphilic copolymer PCL-g-CHT, which has a hydrophobic PCL backbone and hydrophilic CHT grafts. The copolymer self-assembles into nanomicelles and can be used for novel drug delivery systems.
MACROMOLECULAR RAPID COMMUNICATIONS
(2023)
Article
Biotechnology & Applied Microbiology
Linying Li, Xiumei Lin, Jianfeng Bao, Hongmei Xia, Fan Li
Summary: In this study, two novel PCL-degrading enzymes were purified and characterized. PCLase I showed higher degradation ability and was identified as a cutinase, while PCLase II was identified as a lipase.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Jean Coudane, Benjamin Nottelet, Julia Mouton, Xavier Garric, Helene van den Berghe
Summary: Synthetic biopolymers are attractive alternatives to biobased polymers due to their low immune response in living organisms. This review explores the potential of grafting polymer chains onto the backbone of poly E-caprolactone (PCL) to expand its applications, with a focus on the biomedical field.
Article
Polymer Science
Wanhong Zhang, Zhipeng Hou, Siyu Chen, Jing Guo, Jianshe Hu, Liqun Yang, Guiyang Cai
Summary: The amino acid sequence and spatial structure of lipases from different sources often result in significant differences in the active sites, which exhibit differential activity when interacting with a particular polymer, as reflected in the rate of degradation of the polymer. Therefore, studying the degradation properties of enzymes for specific polymers can be a helpful guide in production.
POLYMER DEGRADATION AND STABILITY
(2023)
Article
Polymer Science
Katya Kamenova, Lyubomira Radeva, Spiro Konstantinov, Petar D. Petrov, Krassimira Yoncheva
Summary: This study developed a micellar system for the oral delivery of resveratrol. The micelles showed excellent drug solubilization and bioadhesive properties, leading to better contact with the gastrointestinal mucosa. The micellar formulation demonstrated enhanced anti-inflammatory potential and protective effects compared to pure resveratrol.
Article
Chemistry, Multidisciplinary
Radha Sachan, Sudhir G. Warkar, Roli Purwar
Summary: The shape memory properties of triblock copolymeric films were studied by synthesizing films with varying poly(epsilon-caprolactone) (PCL) chain length and constant polydimethylsiloxane (PDMS) content. The results showed that increasing the PCL chain length led to changes in the crystal morphology, thermal properties, and shape memory performance of the films. The inclusion of PDMS block affected the crystallization kinetics and shape fixity of the films.
Article
Biotechnology & Applied Microbiology
Pranay Amruth Maroju, Pranathi Tata, Aniket Balapure, Jayati Ray Dutta, Ramakrishnan Ganesan
Summary: Lipases-derived from Lactobacilli sp. were used to surface derivatize PCL films with silver, resulting in antimicrobial properties. Two different surface functionalization strategies were employed, both showing successful derivatization of silver over PCL film and enhanced antimicrobial effects in bacterial growth inhibition.
ENZYME AND MICROBIAL TECHNOLOGY
(2021)
Article
Polymer Science
Karolis Norinkevicius, Jeppe Madsen, Line Elmstrom Christiansen, Sebastian Meier, Andreas Horner, Radoslaw Gorecki, Torsten Hoybye Bak Regueira, Anders Egede Daugaard
Summary: The synthesis of block copolymers based on polyethylene glycol (PEG) and polycaprolactone (PCL) was reported. PEG-b-PCL diblock copolymers were prepared using enzymatic and tin-mediated ring-opening polymerization. Well-defined PEG-b-PCL-b-PEG triblock copolymers were synthesized through the coupling of PEG-b-PCL diblock copolymers. The aggregation behavior of diblock and triblock copolymers was studied using a direct hydration technique. The inclusion of amine-functional diblock copolymer favored cylindrical micelle formation.
Article
Biochemistry & Molecular Biology
Evi Christodoulou, Maria Notopoulou, Eirini Nakiou, Margaritis Kostoglou, Panagiotis Barmpalexis, Dimitrios N. Bikiaris
Summary: This study evaluates the use of novel branched poly(epsilon-caprolactone) (PCL)-based copolymers for the preparation of anticancer nanoparticle (NP)-based formulations. The NP formulations prepared using oil-in-water emulsion showed small size, high encapsulation efficiency, and enhanced drug dissolution rate and solubility.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Polymer Science
Maria Nunez, Sebastian Munoz-Guerra, Antxon Martinez de Ilarduya
Summary: This study investigates the enzymatic synthesis of poly(butylene-co-epsilon-caprolactone) copolyesters for the first time, demonstrating high thermal stability and semicrystalline properties. The use of Candida antarctica lipase B resulted in copolyesters free from toxic metallic catalysts, making them potential candidates for biomedical applications.
Article
Materials Science, Multidisciplinary
Nikola Toshikj, Jean-Jacques Robin, Michel Ramonda, Sylvain Catrouillet, Sebastien Blanquer
Summary: Efficient and rapid organocatalyzed ring-opening polymerization was used to synthesize PTMC-b-PCL-b-PTMC block copolymers, with controlled architectures achieved through an additional cross-linking step. The crystalline-driven phase-separated morphology predominated, and the cross-linked thin films exhibited shape-memory properties, while remaining stable with access to thermodynamic phase-separated morphologies below the poly(epsilon-caprolactone) melting point.
ACS APPLIED POLYMER MATERIALS
(2021)
Article
Polymer Science
Leonard Ionut Atanase, Slim Salhi, Oana Cucoveica, Marijana Ponjavic, Jasmina Nikodinovic-Runic, Christelle Delaite
Summary: Biodegradable polymers have great significance in biomedical applications as they can degrade in the body, eliminating the need for retrieval or explant. This study obtained a series of PCL-b-PEA-b-PCL block copolymers with varying PCL sequence lengths, and found that the presence of the PEA central sequence has an important influence on the biodegradability of the copolymer samples.
Article
Biotechnology & Applied Microbiology
Misbah Amin, Haq N. Bhatti, Muhammad Bilal
Summary: The study focuses on the biochemical characterization of a lipase produced by Aspergillus melleus through solid-state fermentation, showcasing its broad working pH, stability in the presence of organic solvents, and excellent ability to degrade poly(e-caprolactone). The lipase exhibited optimal activity at pH 7.5 and 40°C, with good stability even after 24 hours, making it a promising candidate for large-scale bioremediation of solid waste.
JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY
(2022)
Article
Polymer Science
Kenta Hashimoto, Naruki Kurokawa, Atsushi Hotta
Summary: New biodegradable shape-memory polymers (SMPs) were synthesized by blending PLCL and sc-PLA, showing controllable switching temperatures and shape-recovery ratios. The SMPs can be used as biomaterials for medical devices.
Article
Materials Science, Characterization & Testing
Lidong Feng, Sheng Xiang, Yanlong Liu, Xinchao Bian, Gao Li, Xuesi Chen
Summary: An analytical method using gas chromatography with an internal standard was developed to quantitatively determine residual monomers in PLCL, which showed high precision with RSD less than 5.6% and 4.3% for LA and CL measurements, respectively. The recovery rate of standard addition for LA and CL in PLCL was between 96.5%-101.5% and 98.4%-104.2%, with RSD not exceeding 2.0%, indicating the method was sufficiently accurate.