Journal
STEM CELL REPORTS
Volume 5, Issue 3, Pages 365-377Publisher
CELL PRESS
DOI: 10.1016/j.stemcr.2015.06.006
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Funding
- Ministry of Education, Culture, Sports, Science, and Technology (MEXT) of Japan
- National Health and Medical Research Council (NHMRC, Australia) [1048849]
- Australian Research Council [DP140101499]
- MEXT
- Japan Society for the Promotion of Science Research Fellowship Program
- NHMRC Principal Research Fellowship
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Mammalian neural stem/progenitor cells (NSPCs) sequentially generate neurons and glia during CNS development. Here we identified miRNA-153 (miR-153) as a modulator of the temporal regulation of NSPC differentiation. Overexpression (OE) of miR-153 delayed the onset of astrogliogenesis and maintained NSPCs in an undifferentiated state in vitro and in the developing cortex. The transcription factors nuclear factor I (NFI) A and B, essential regulators of the initiation of gliogenesis, were found to be targets of miR-153. Inhibition of miR-153 in early neurogenic NSPCs induced precocious gliogenesis, whereas NFIA/B overexpression rescued the anti-gliogenic phenotypes induced by miR-153 OE. Our results indicate that miR-mediated fine control of NFIA/B expression is important in the molecular networks that regulate the acquisition of gliogenic competence by NSPCs in the developing CNS.
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