Journal
PROTEIN & CELL
Volume 4, Issue 10, Pages 723-725Publisher
HIGHER EDUCATION PRESS
DOI: 10.1007/s13238-013-3913-0
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Funding
- NCI NIH HHS [R00 CA158055] Funding Source: Medline
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Hannum and colleagues performed DNA methylation sequencing to examine the relationship between DNA methylome and aging rate. Notably, they succeeded in building a quantitative and reproducible model based on the epigenetic bio-markers to predict aging rate with high accuracy. This progress enlightens us in many aspects particularly in applying this novel set of bio-markers on studying the mechanism of aging rate using adult tissue-specific stem cells, building up a potential quantitative model to explore the mechanism for other epigenetic factors like non-coding RNA, and understanding the principle and mechanism of 3D chromatin structure in epigenetic modulation.
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