Binding of bacterial secondary messenger molecule c di-GMP is a STING operation

Structural Analysis of the STING Adaptor Protein Reveals a Hydrophobic Dimer Interface and Mode of Cyclic di-GMP Binding

(2012) Songying Ouyang et al.   IMMUNITY

Sensing of RNA Viruses: a Review of Innate Immune Receptors Involved in Recognizing RNA Virus Invasion

(2012) S. Jensen et al.   JOURNAL OF VIROLOGY

Cyclic di-GMP Sensing via the Innate Immune Signaling Protein STING

(2012) Qian Yin et al.   MOLECULAR CELL

Inflammasomes: far beyond inflammation

(2012) Jorge Henao-Mejia et al.   NATURE IMMUNOLOGY

Structure of STING bound to cyclic di-GMP reveals the mechanism of cyclic dinucleotide recognition by the immune system

(2012) Chang Shu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The structural basis for the sensing and binding of cyclic di-GMP by STING

(2012) Yi-He Huang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Crystal structures of STING protein reveal basis for recognition of cyclic di-GMP

(2012) Guijun Shang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

STING Specifies IRF3 Phosphorylation by TBK1 in the Cytosolic DNA Signaling Pathway

(2012) Y. Tanaka et al.   Science Signaling

STING Mediates Neuronal Innate Immune Response Following Japanese Encephalitis Virus Infection

(2012) Arshed Nazmi et al.   Scientific Reports

Activation of STAT6 by STING Is Critical for Antiviral Innate Immunity

(2011) Huihui Chen et al.   CELL

Innate immune DNA sensing pathways: STING, AIMII and the regulation of interferon production and inflammatory responses

(2011) Glen N Barber   CURRENT OPINION IN IMMUNOLOGY

Cytoplasmic DNA innate immune pathways

(2011) Glen N. Barber   IMMUNOLOGICAL REVIEWS

TRIM56 Is a Virus- and Interferon-Inducible E3 Ubiquitin Ligase That Restricts Pestivirus Infection

(2011) J. Wang et al.   JOURNAL OF VIROLOGY

STING is a direct innate immune sensor of cyclic di-GMP

(2011) Dara L. Burdette et al.   NATURE

The helicase DDX41 senses intracellular DNA mediated by the adaptor STING in dendritic cells

(2011) Zhiqiang Zhang et al.   NATURE IMMUNOLOGY

What Determines the Specificity and Outcomes of Ubiquitin Signaling?

(2010) Fumiyo Ikeda et al.   CELL

Peroxisomes Are Signaling Platforms for Antiviral Innate Immunity

(2010) Evelyn Dixit et al.   CELL

Reconstitution of the RIG-I Pathway Reveals a Signaling Role of Unanchored Polyubiquitin Chains in Innate Immunity

(2010) Wenwen Zeng et al.   CELL

The STING pathway and regulation of innate immune signaling in response to DNA pathogens

(2010) Hiroki Ishikawa et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The Ubiquitin Ligase TRIM56 Regulates Innate Immune Responses to Intracellular Double-Stranded DNA

(2010) Tetsuo Tsuchida et al.   IMMUNITY

TheN-Ethyl-N-Nitrosourea-InducedGoldenticketMouse Mutant Reveals an Essential Function ofStingin theIn VivoInterferon Response toListeria monocytogenesand Cyclic Dinucleotides

(2010) John-Demian Sauer et al.   INFECTION AND IMMUNITY

Stimulator of IFN Gene Is Critical for Induction of IFN-β during Chlamydia muridarum Infection

(2010) Daniel Prantner et al.   JOURNAL OF IMMUNOLOGY

The cytosolic exonuclease TREX1 inhibits the innate immune response to human immunodeficiency virus type 1

(2010) Nan Yan et al.   NATURE IMMUNOLOGY

Toll-like Receptor and RIG-1-like Receptor Signaling

(2009) Taro Kawai et al.   Annals of the New York Academy of Sciences

Antiviral defense: RIG-Ing the immune system to STING

(2009) J. Bradford Bowzard et al.   CYTOKINE & GROWTH FACTOR REVIEWS

The Ubiquitin Ligase RNF5 Regulates Antiviral Responses by Mediating Degradation of the Adaptor Protein MITA

(2009) Bo Zhong et al.   IMMUNITY

STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity

(2009) Hiroki Ishikawa et al.   NATURE

Protein structure prediction on the Web: a case study using the Phyre server

(2009) Lawrence A Kelley et al.   Nature Protocols

Atg9a controls dsDNA-driven dynamic translocation of STING and the innate immune response

(2009) T. Saitoh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ERIS, an endoplasmic reticulum IFN stimulator, activates innate immune signaling through dimerization

(2009) W. Sun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Recognition of viral nucleic acids in innate immunity

(2009) Mitsutoshi Yoneyama et al.   REVIEWS IN MEDICAL VIROLOGY

STING-ing the Antiviral Pathway

(2009) P. Nakhaei et al.   Journal of Molecular Cell Biology

TLR9 as a key receptor for the recognition of DNA☆

(2008) Y KUMAGAI et al.   ADVANCED DRUG DELIVERY REVIEWS

LPS/TLR4 signal transduction pathway

(2008) Yong-Chen Lu et al.   CYTOKINE

The Adaptor Protein MITA Links Virus-Sensing Receptors to IRF3 Transcription Factor Activation

(2008) Bo Zhong et al.   IMMUNITY

MPYS, a Novel Membrane Tetraspanner, Is Associated with Major Histocompatibility Complex Class II and Mediates Transduction of Apoptotic Signals

(2008) L. Jin et al.   MOLECULAR AND CELLULAR BIOLOGY

STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling

(2008) Hiroki Ishikawa et al.   NATURE