Current understanding of Th2 cell differentiation and function

ECM1 controls TH2 cell egress from lymph nodes through re-expression of S1P1

(2011) Zhenhu Li et al.   NATURE IMMUNOLOGY

Differentiation of Effector CD4 T Cell Populations

(2010) Jinfang Zhu et al.   Annual Review of Immunology

Interferon-Regulatory Factor 4 Is Essential for the Developmental Program of T Helper 9 Cells

(2010) Valérie Staudt et al.   IMMUNITY

Interferons Direct Th2 Cell Reprogramming to Generate a Stable GATA-3+T-bet+ Cell Subset with Combined Th2 and Th1 Cell Functions

(2010) Ahmed N. Hegazy et al.   IMMUNITY

IL-21 acts directly on B cells to regulate Bcl-6 expression and germinal center responses

(2010) Michelle A. Linterman et al.   JOURNAL OF EXPERIMENTAL MEDICINE

IL-21 regulates germinal center B cell differentiation and proliferation through a B cell–intrinsic mechanism

(2010) Dimitra Zotos et al.   JOURNAL OF EXPERIMENTAL MEDICINE

TGF-  Induces IL-9 Production from Human Th17 Cells

(2010) G. Beriou et al.   JOURNAL OF IMMUNOLOGY

Germinal Center T Follicular Helper Cell IL-4 Production Is Dependent on Signaling Lymphocytic Activation Molecule Receptor (CD150)

(2010) I. Yusuf et al.   JOURNAL OF IMMUNOLOGY

Regulation of IL-9 expression by IL-25 signaling

(2010) Pornpimon Angkasekwinai et al.   NATURE IMMUNOLOGY

The transcription factor PU.1 is required for the development of IL-9-producing T cells and allergic inflammation

(2010) Hua-Chen Chang et al.   NATURE IMMUNOLOGY

The enhancer HS2 critically regulates GATA-3-mediated Il4 transcription in TH2 cells

(2010) Shinya Tanaka et al.   NATURE IMMUNOLOGY

Global Mapping of H3K4me3 and H3K27me3 Reveals Specificity and Plasticity in Lineage Fate Determination of Differentiating CD4+ T Cells

(2009) Gang Wei et al.   IMMUNITY

The Transcriptional Repressor Bcl-6 Directs T Follicular Helper Cell Lineage Commitment

(2009) Di Yu et al.   IMMUNITY

Late Developmental Plasticity in the T Helper 17 Lineage

(2009) Yun Kyung Lee et al.   IMMUNITY

T follicular helper cells differentiate from Th2 cells in response to helminth antigens

(2009) Arielle Glatman Zaretsky et al.   JOURNAL OF EXPERIMENTAL MEDICINE

IL-4–producing CD4+T cells in reactive lymph nodes during helminth infection are T follicular helper cells

(2009) Irah L. King et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Dec2 Promotes Th2 Cell Differentiation by Enhancing IL-2R Signaling

(2009) Z. Liu et al.   JOURNAL OF IMMUNOLOGY

Requirement for the basic helix-loop-helix transcription factor Dec2 in initial TH2 lineage commitment

(2009) Xuexian O Yang et al.   NATURE IMMUNOLOGY

The function of follicular helper T cells is regulated by the strength of T cell antigen receptor binding

(2009) Nicolas Fazilleau et al.   NATURE IMMUNOLOGY

Cytokine-secreting follicular T cells shape the antibody repertoire

(2009) R Lee Reinhardt et al.   NATURE IMMUNOLOGY

Bcl6 and Blimp-1 Are Reciprocal and Antagonistic Regulators of T Follicular Helper Cell Differentiation

(2009) R. J. Johnston et al.   SCIENCE

Bcl6 Mediates the Development of T Follicular Helper Cells

(2009) R. I. Nurieva et al.   SCIENCE

T Cell Trafficking in Allergic Asthma: The Ins and Outs

(2008) Benjamin D. Medoff et al.   Annual Review of Immunology

Generation of T Follicular Helper Cells Is Mediated by Interleukin-21 but Independent of T Helper 1, 2, or 17 Cell Lineages

(2008) Roza I. Nurieva et al.   IMMUNITY

Molecular Antagonism and Plasticity of Regulatory and Inflammatory T Cell Programs

(2008) Xuexian O. Yang et al.   IMMUNITY

Transforming growth factor-β 'reprograms' the differentiation of T helper 2 cells and promotes an interleukin 9–producing subset

(2008) Marc Veldhoen et al.   NATURE IMMUNOLOGY

IL-4 inhibits TGF-β-induced Foxp3+ T cells and, together with TGF-β, generates IL-9+ IL-10+ Foxp3− effector T cells

(2008) Valérie Dardalhon et al.   NATURE IMMUNOLOGY

Notch and Presenilin Regulate Cellular Expansion and Cytokine Secretion but Cannot Instruct Th1/Th2 Fate Acquisition

(2008) Chin-Tong Ong et al.   PLoS One