Expanding neurotransmitters in the hypothalamic neurocircuitry for energy balance regulation

The Development and Application of Optogenetics

(2011) Lief Fenno et al.   Annual Review of Neuroscience

Molecular mapping of mouse brain regions innervated by leptin receptor-expressing cells

(2011) Christa M. Patterson et al.   BRAIN RESEARCH

Hunger States Switch a Flip-Flop Memory Circuit via a Synaptic AMPK-Dependent Positive Feedback Loop

(2011) Yunlei Yang et al.   CELL

Knockdown of NPY Expression in the Dorsomedial Hypothalamus Promotes Development of Brown Adipocytes and Prevents Diet-Induced Obesity

(2011) Pei-Ting Chao et al.   Cell Metabolism

Leptin Therapy Reverses Hyperglycemia in Mice With Streptozotocin-Induced Diabetes, Independent of Hepatic Leptin Signaling

(2011) H. C. Denroche et al.   DIABETES

Molecular Mapping of the Neural Pathways Linking Leptin to the Neuroendocrine Reproductive Axis

(2011) Gwendolyn W. Louis et al.   ENDOCRINOLOGY

Generation of the tamoxifen-inducible DBH-Cre transgenic mouse line DBH-CT

(2011) Jutta Stubbusch et al.   GENESIS

Rapid, reversible activation of AgRP neurons drives feeding behavior in mice

(2011) Michael J. Krashes et al.   JOURNAL OF CLINICAL INVESTIGATION

Leptin Action in the Dorsomedial Hypothalamus Increases Sympathetic Tone to Brown Adipose Tissue in Spite of Systemic Leptin Resistance

(2011) P. J. Enriori et al.   JOURNAL OF NEUROSCIENCE

Leptin-Receptor-Expressing Neurons in the Dorsomedial Hypothalamus and Median Preoptic Area Regulate Sympathetic Brown Adipose Tissue Circuits

(2011) Y. Zhang et al.   JOURNAL OF NEUROSCIENCE

The global obesity pandemic: shaped by global drivers and local environments

(2011) Boyd A Swinburn et al.   LANCET

Health and economic burden of the projected obesity trends in the USA and the UK

(2011) Y Claire Wang et al.   LANCET

AGRP neurons are sufficient to orchestrate feeding behavior rapidly and without training

(2011) Yexica Aponte et al.   NATURE NEUROSCIENCE

An optogenetic toolbox designed for primates

(2011) Ilka Diester et al.   NATURE NEUROSCIENCE

Synaptotagmin 4: A New Antiobesity Target?

(2011) Qingchun Tong   NEURON

Neuropeptide Exocytosis Involving Synaptotagmin-4 and Oxytocin in Hypothalamic Programming of Body Weight and Energy Balance

(2011) Guo Zhang et al.   NEURON

Leptin Action on GABAergic Neurons Prevents Obesity and Reduces Inhibitory Tone to POMC Neurons

(2011) Linh Vong et al.   NEURON

CART peptide stimulation of G protein-mediated signaling in differentiated PC12 Cells: Identification of PACAP 6–38 as a CART receptor antagonist

(2011) Yiming Lin et al.   NEUROPEPTIDES

Lateral thinking about leptin: A review of leptin action via the lateral hypothalamus

(2011) Gina M. Leinninger   PHYSIOLOGY & BEHAVIOR

Nicotine Decreases Food Intake Through Activation of POMC Neurons

(2011) Y. S. Mineur et al.   SCIENCE

Leptin treatment confers clinical benefit at multiple stages of virally induced type 1 diabetes in BB rats

(2010) Annie J. Kruger et al.   AUTOIMMUNITY

Neurodevelopmental actions of leptin

(2010) Sebastien G. Bouret   BRAIN RESEARCH

Lasker Lauds Leptin

(2010) Jeffrey S. Flier et al.   CELL

Glucose Stimulation of Hypothalamic MCH Neurons Involves KATP Channels, Is Modulated by UCP2, and Regulates Peripheral Glucose Homeostasis

(2010) Dong Kong et al.   Cell Metabolism

Leptin Activates a Novel CNS Mechanism for Insulin-Independent Normalization of Severe Diabetic Hyperglycemia

(2010) Jonathan P. German et al.   ENDOCRINOLOGY

Galanin-like peptide and the regulation of feeding behavior and energy metabolism

(2010) Kanako Shiba et al.   FEBS Journal

Brain expression of Cre recombinase driven by pancreas-specific promoters

(2010) Junghun Song et al.   GENESIS

Segregation of Acute Leptin and Insulin Effects in Distinct Populations of Arcuate Proopiomelanocortin Neurons

(2010) K. W. Williams et al.   JOURNAL OF NEUROSCIENCE

Pomc-expressing progenitors give rise to antagonistic neuronal populations in hypothalamic feeding circuits

(2010) Stephanie L Padilla et al.   NATURE MEDICINE

Optogenetics

(2010) Karl Deisseroth   NATURE METHODS

5-HT2CRs expressed by pro-opiomelanocortin neurons regulate insulin sensitivity in liver

(2010) Yong Xu et al.   NATURE NEUROSCIENCE

Transient neuronal inhibition reveals opposing roles of indirect and direct pathways in sensitization

(2010) Susan M Ferguson et al.   NATURE NEUROSCIENCE

Characterization of Kiss1 neurons using transgenic mouse models

(2010) R.M. Cravo et al.   NEUROSCIENCE

Multinodal regulation of the arcuate/paraventricular nucleus circuit by leptin

(2010) M. Ghamari-Langroudi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Leptin therapy in insulin-deficient type I diabetes

(2010) M.-y. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Leptin therapy improves insulin-deficient type 1 diabetes by CNS-dependent mechanisms in mice

(2010) T. Fujikawa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Obesity and leptin resistance: distinguishing cause from effect

(2010) Martin G. Myers et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Optogenetic deconstruction of sleep-wake circuitry in the brain

(2010) Antoine Adamantidis   Frontiers in Molecular Neuroscience

Recent advances in understanding leptin signaling and leptin resistance

(2009) David L. Morris et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Endogenous ACTH, not only α-melanocyte-stimulating hormone, reduces food intake mediated by hypothalamic mechanisms

(2009) Carla Schulz et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Hypothalamic nutrient sensing in the control of energy homeostasis

(2009) Clémence Blouet et al.   BEHAVIOURAL BRAIN RESEARCH

Loss of GABAergic Signaling by AgRP Neurons to the Parabrachial Nucleus Leads to Starvation

(2009) Qi Wu et al.   CELL

The Geometry of Leptin Action in the Brain: More Complicated Than a Simple ARC

(2009) Martin G. Myers et al.   Cell Metabolism

Leptin-Dependent Control of Glucose Balance and Locomotor Activity by POMC Neurons

(2009) Lihong Huo et al.   Cell Metabolism

Leptin Acts via Leptin Receptor-Expressing Lateral Hypothalamic Neurons to Modulate the Mesolimbic Dopamine System and Suppress Feeding

(2009) Gina M. Leinninger et al.   Cell Metabolism

Leptin targets in the mouse brain

(2009) Michael M. Scott et al.   JOURNAL OF COMPARATIVE NEUROLOGY

PACAP Neurons in the Hypothalamic Ventromedial Nucleus Are Targets of Central Leptin Signaling

(2009) Z. Hawke et al.   JOURNAL OF NEUROSCIENCE

The obesity susceptibility gene Cpe links FoxO1 signaling in hypothalamic pro-opiomelanocortin neurons with regulation of food intake

(2009) Leona Plum et al.   NATURE MEDICINE

Remote Control of Neuronal Activity in Transgenic Mice Expressing Evolved G Protein-Coupled Receptors

(2009) Georgia M. Alexander et al.   NEURON

Altered response to metabolic challenges in mice with genetically targeted deletions of galanin-like peptide

(2008) Heather M. Dungan Lemko et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Hypothalamic pathways linking energy balance and reproduction

(2008) Jennifer W. Hill et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Dysregulation of the Mesolimbic Dopamine System and Reward in MCH−/− Mice

(2008) Pavlos Pissios et al.   BIOLOGICAL PSYCHIATRY

Leptin: Linking obesity, the metabolic syndrome, and cardiovascular disease

(2008) Sanjeev B. Patel et al.   CURRENT HYPERTENSION REPORTS

Temporal and Spatial Regulation of CRE Recombinase Expression in Gonadotrophin-Releasing Hormone Neurones in the Mouse

(2008) A. Wolfe et al.   JOURNAL OF NEUROENDOCRINOLOGY

Oxytocin Deficiency Mediates Hyperphagic Obesity ofSim1Haploinsufficient Mice

(2008) Bassil M. Kublaoui et al.   MOLECULAR ENDOCRINOLOGY

Synaptic release of GABA by AgRP neurons is required for normal regulation of energy balance

(2008) Qingchun Tong et al.   NATURE NEUROSCIENCE

Neurobiology of Nutrition and Obesity

(2008) Christopher D. Morrison et al.   NUTRITION REVIEWS

Starvation after AgRP neuron ablation is independent of melanocortin signaling

(2008) Q. Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Making insulin-deficient type 1 diabetic rodents thrive without insulin

(2008) X. Yu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Brain, Appetite, and Obesity

(2007) Hans-Rudolf Berthoud et al.   Annual Review of Psychology

Inhibition of Agouti-Related Peptide Expression by Glucose in a Clonal Hypothalamic Neuronal Cell Line Is Mediated by Glycolysis, Not Oxidative Phosphorylation

(2007) Hui Cheng et al.   ENDOCRINOLOGY

Collective and Individual Functions of Leptin Receptor Modulated Neurons Controlling Metabolism and Ingestion

(2007) Esther van de Wall et al.   ENDOCRINOLOGY