Journal
PEERJ
Volume 3, Issue -, Pages -Publisher
PEERJ INC
DOI: 10.7717/peerj.834
Keywords
Cerebral blood flow; ASL; Arterial spin labeling; fMRI; Functional magnetic resonance imaging; Cerebral blood flow measurement; Parkinson's disease
Categories
Funding
- Synosia Therapeutics
- NIH [K24 MH087913, T32 DA007261, NS058714, NS41509, NS075321, C06 RR020092, UL1 RR024992, P30 NS048056, U54 CA136398-02900209]
- American Parkinson Disease Association (APDA) Center for Advanced PD Research at Washington University
- Greater St. Louis Chapter of the APDA
- Barnes-Jewish Hospital Foundation (Elliot Stein Family Fund for PD Research)
- Barnes-Jewish Hospital Foundation (Parkinson Disease Research Fund)
- NATIONAL CANCER INSTITUTE [U54CA136398] Funding Source: NIH RePORTER
- NATIONAL CENTER FOR RESEARCH RESOURCES [C06RR020092] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF MENTAL HEALTH [K24MH087913] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R01NS058714, R01NS041509, P30NS048056, R01NS075321] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON DRUG ABUSE [T32DA007261] Funding Source: NIH RePORTER
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To determine how different methods of normalizing for global cerebral blood flow (gCBF) affect image quality and sensitivity to cortical activation, pulsed arterial spin labeling (pASL) scans obtained during a visual task were normalized by either additive or multiplicative normalization of modal gCBF. Normalization by either method increased the statistical significance of cortical activation by a visual stimulus. However, image quality was superior with additive normalization, whether judged by intensity histograms or by reduced variability within gray and white matter.
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