Article
Multidisciplinary Sciences
Wenwen Wang, Yujia Yang, Suxu Tan, Tao Zhou, Yang Liu, Changxu Tian, Lisui Bao, De Xing, Baofeng Su, Jinhai Wang, Yu Zhang, Shikai Liu, Huitong Shi, Dongya Gao, Rex Dunham, Zhanjiang Liu
Summary: The X and Y chromosomes of channel catfish have the same gene contents. The X-borne hydin-1 gene is silenced, while the Y-borne hydin-1 gene is expressed, resulting in monoallelic expression of hydin-1 responsible for sex determination, similar to genomic imprinting. Treatment with a methylation inhibitor, 5-aza-dC, erases the epigenetic marks and causes sex reversal.
Article
Biochemistry & Molecular Biology
Michail Rovatsos, Lukas Kratochvil
Summary: Organisms have evolved various mechanisms to cope with differences in gene copy numbers caused by degeneration of sex chromosomes. Different gene dose regulatory mechanisms were found in reptilian lineages with independently co-opted the same ancestral genomic region for sex chromosomes. The variability in gene dose regulation is not merely a consequence of ancestral autosomal gene content.
Article
Biochemical Research Methods
Sarah M. Mangiameli, Haiqi Chen, Andrew S. Earl, Julie A. Dobkin, Daniel Lesman, Jason D. Buenrostro, Fei Chen
Summary: Photoselective sequencing is a new method for genomic and epigenomic profiling in morphologically distinct regions. It uses targeted illumination to selectively unblock a photocaged fragment library, enabling sequencing-based readout in microscopically identified spatial regions. The method was validated by analyzing chromatin accessibility profiles of fluorescently-labeled cell types in the mouse brain and comparing with published data. Photoselective sequencing is a flexible and generalizable platform for studying the interplay of spatial structures with genomic and epigenomic properties.
Review
Biology
Aivars Cirulis, Bengt Hansson, Jessica K. Abbott
Summary: This article provides an overview of the effects of sex-limited chromosomes on non-reproductive traits and discusses the evolutionary processes maintaining variation at sex-limited chromosomes and the molecular mechanisms affecting non-reproductive traits.
Article
Genetics & Heredity
Miao Ding, Xi-Yin Li, Zhi-Xuan Zhu, Jun-Hui Chen, Meng Lu, Qian Shi, Yang Wang, Zhi Li, Xin Zhao, Tao Wang, Wen-Xuan Du, Chun Miao, Tian-Zi Yao, Ming-Tao Wang, Xiao-Juan Zhang, Zhong-Wei Wang, Li Zhou, Jian-Fang Gui
Summary: Unisexual taxa are often considered short-lived due to the accumulation of deleterious mutations caused by the absence of meiotic recombination. However, the gynogenetic gibel carp has shown exceptional longevity and strong environmental adaptation. Male occurrence in this species is associated with male-specific microchromosomes containing homologous sequences of autosomes and abundant repetitive elements, which are likely the main driving force for male occurrence in gynogenetic gibel carp.
Article
Multidisciplinary Sciences
Matthew B. Couger, Scott W. Roy, Noelle Anderson, Landen Gozashti, Stacy Pirro, Lindsay S. Millward, Michelle Kim, Duncan Kilburn, Kelvin J. Liu, Todd M. Wilson, Clinton W. Epps, Laurie Dizney, Luis A. Ruedas, Polly Campbell
Summary: The sex chromosome system of the creeping vole is unique, with females having an unpaired X chromosome (X0) and the sex chromosome being one of the two X chromosomes, both carrying fragments of the ancestral Y chromosome. The consequences of this transformed sex chromosome system in this species include Y-like degeneration, expression of Y-linked genes in females, and X inactivation of the male-specific chromosome in male somatic cells.
Article
Biochemical Research Methods
Asia Mendelevich, Saumya Gupta, Aleksei Pakharev, Athanasios Teodosiadis, Andrey A. Mironov, Alexander A. Gimelbrant
Summary: A new spike-in approach is developed to correct technical noise in allele-specific expression analysis, which is highly accurate and cost-effective. This approach involves adding a distinct RNA as a spike-in before library preparation, allowing for efficient analysis of allele-specific expression in large studies.
Article
Plant Sciences
Florence Ngo Ngwe, Sonja Siljak-Yakovlev
Summary: We studied the sex chromosomes of Dioscorea dumetorum in Cameroon and found that one pair of chromosomes is sex chromosomes. This research contributes to our understanding of the sex determination mechanism in D. dumetorum (standard sex-determining XX/XY system).
Article
Genetics & Heredity
Artem Lisachov, Daria Andreyushkova, Guzel Davletshina, Dmitry Prokopov, Svetlana Romanenko, Svetlana Galkina, Alsu Saifitdinova, Evgeniy Simonov, Pavel Borodin, Vladimir Trifonov
Summary: The study found that the lizard W chromosome contains a new repetitive sequence from different sources, indicating a complex evolutionary trajectory. While it remains unclear if the W chromosome is able to produce a protein product, it still exhibits transcriptional activity. Further research is needed to confirm the presence of this new element in other lizard species and its possible functionality.
Article
Biochemistry & Molecular Biology
Renan Sauteraud, Jill M. Stahl, Jesica James, Marisa Englebright, Fang Chen, Xiaowei Zhan, Laura Carrel, Dajiang J. Liu
Summary: The X Chromosome plays a crucial role in human development and disease, with XCI influencing the expression of escape genes and impacting the etiology of sex-biased disorders. Research indicates that escape genes, particularly those with Y homology, contribute significantly to X heritability. Additionally, the enrichment of variable escape genes is higher in female-biased diseases, highlighting their importance in the disease mechanism.
Article
Multidisciplinary Sciences
Christophe Dufresnes, Alan Brelsford, Daniel L. Jeffries, Glib Mazepa, Tomasz Suchan, Daniele Canestrelli, Alfredo Nicieza, Luca Fumagalli, Sylvain Dubey, Inigo Martinez-Solano, Spartak N. Litvinchuk, Miguel Vences, Nicolas Perrin, Pierre-Andre Crochet
Summary: Research on frog and toad hybrid zones suggests that as lineages diverge, parts of the genome resist introgression, indicating that anuran speciation involves the gradual accumulation of multiple barrier loci scattered across the genome. This highly polygenic nature of reproductive isolation, along with the lack of hemizygous sex chromosomes, may explain the slower speciation clock in amphibians compared to other vertebrates.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Geriatrics & Gerontology
Natasha L. Pacheco, Nicole Noren Hooten, Yongqing Zhang, Calais S. Prince, Nicolle A. Mode, Ngozi Ezike, Kevin G. Becker, Alan B. Zonderman, Michele K. Evans
Summary: The study revealed sex-specific transcriptional changes in middle-aged frailty, aiding in the understanding of frailty progression and providing potential therapeutic targets for preventing frailty.
Article
Multidisciplinary Sciences
Maohua Yuan, Xianmei Yin, Bixing Gao, Rui Gu, Guihua Jiang
Summary: This study analyzed the chloroplast genomes of several Caragana species and found that they have similar genome structures and repeat sequences. The chloroplast genomes can be used for identification and classification of Caragana species, and they are also useful for further phylogenetic studies.
Article
Biotechnology & Applied Microbiology
Jiao Wang, Yue Lan, Lewei He, Ruixiang Tang, Yuhui Li, Yuan Huang, Shan Liang, Zhan Gao, Megan Price, Bisong Yue, Miao He, Tao Guo, Zhenxin Fan
Summary: The study revealed sex-specific gene expression differences in the blood tissues of four primates, with 31 sex-specific differentially expressed genes identified in humans. Most XY gene pairs had similar expression levels between species, except for one pair (EIF1AY/EIF1AX). Humans had significant XY-biased and XX-biased X-Y gene pairs, while rhesus and Tibetan macaques did not show significant differential expression levels in their X-Y gene pairs.
Article
Biochemistry & Molecular Biology
Marwan Elkrewi, Mikhail A. Moldovan, Marion A. L. Picard, Beatriz Vicoso
Summary: This study characterizes the gene content and evolution of the W-chromosomes in Schistosoma mansoni and S. japonicum. W-linked genes show evidence of degeneration, with high rates of protein evolution and reduced expression, mainly located in young lineage-specific strata. The splicing factor u2af2 is highlighted as a potential candidate for primary sex determination.
MOLECULAR BIOLOGY AND EVOLUTION
(2021)
Article
Developmental Biology
Catherine D. McCusker, Antony Athippozhy, Carlos Diaz-Castillo, Charless Fowlkes, David M. Gardiner, Randal Voss
BMC DEVELOPMENTAL BIOLOGY
(2015)
Article
Developmental Biology
Catherine D. McCusker, Carlos Diaz-Castillo, Julian Sosnik, Anne Q. Phan, David M. Gardiner
DEVELOPMENTAL BIOLOGY
(2016)
Article
Evolutionary Biology
Carlos Diaz-Castillo
EVOLUTIONARY BIOLOGY
(2017)
Article
Multidisciplinary Sciences
Raquel Chamorro-Garcia, Carlos Diaz-Castillo, Bassem M. Shoucri, Heidi Kach, Ron Leavitt, Toshi Shioda, Bruce Blumberg
NATURE COMMUNICATIONS
(2017)
Article
Multidisciplinary Sciences
Carlos Diaz-Castillo
Article
Evolutionary Biology
Carlos Diaz-Castillo
EVOLUTIONARY BIOLOGY
(2018)
Article
Biochemistry & Molecular Biology
Carlos Diaz-Castillo, Jose M. Ranz
Article
Biochemistry & Molecular Biology
Jose M. Ranz, Carlos Diaz-Castillo, Rita Petersen
MOLECULAR BIOLOGY AND EVOLUTION
(2012)
Article
Biochemistry & Molecular Biology
Carlos Diaz-Castillo, Jose M. Ranz
MOLECULAR BIOLOGY AND EVOLUTION
(2012)
Article
Multidisciplinary Sciences
Carlos Diaz-Castillo
Article
Genetics & Heredity
Carlos Diaz-Castillo, Xiao-Qin Xia, Jose M. Ranz
Article
Multidisciplinary Sciences
Carlos Diaz-Castillo, Raquel Chamorro-Garcia, Toshi Shioda, Bruce Blumberg
SCIENTIFIC REPORTS
(2019)
Review
Toxicology
Daniel D. Davis, Carlos Diaz-Castillo, Raquel Chamorro-Garcia
Summary: The role of environment in the development of diseases has long been known, but it is still unclear how different environmental factors interact to cause diseases. Metabolic disorders such as obesity and type 2 diabetes are associated with exposure to environmental chemicals during critical windows of susceptibility, such as the periconception, prenatal, and early life periods, and this effect can persist through development and across generations.
FRONTIERS IN TOXICOLOGY
(2022)
Article
Multidisciplinary Sciences
Catherine D. McCusker, Carlos Diaz-Castillo, Julian Sosnik, Anne Phan, David M. Gardiner